ID H3BUA4_HUMAN Unreviewed; 123 AA.
AC H3BUA4;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 1.
DT 27-MAR-2024, entry version 65.
DE RecName: Full=Y+L amino acid transporter 2 {ECO:0000256|ARBA:ARBA00039563};
DE AltName: Full=Solute carrier family 7 member 6 {ECO:0000256|ARBA:ARBA00042899};
DE AltName: Full=y(+)L-type amino acid transporter 2 {ECO:0000256|ARBA:ARBA00042001};
DE Flags: Fragment;
GN Name=SLC7A6 {ECO:0000313|Ensembl:ENSP00000457550.1};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000457550.1, ECO:0000313|Proteomes:UP000005640};
RN [1] {ECO:0000313|Ensembl:ENSP00000457550.1, ECO:0000313|Proteomes:UP000005640}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15616553; DOI=10.1038/nature03187;
RA Martin J., Han C., Gordon L.A., Terry A., Prabhakar S., She X., Xie G.,
RA Hellsten U., Chan Y.M., Altherr M., Couronne O., Aerts A., Bajorek E.,
RA Black S., Blumer H., Branscomb E., Brown N.C., Bruno W.J., Buckingham J.M.,
RA Callen D.F., Campbell C.S., Campbell M.L., Campbell E.W., Caoile C.,
RA Challacombe J.F., Chasteen L.A., Chertkov O., Chi H.C., Christensen M.,
RA Clark L.M., Cohn J.D., Denys M., Detter J.C., Dickson M.,
RA Dimitrijevic-Bussod M., Escobar J., Fawcett J.J., Flowers D., Fotopulos D.,
RA Glavina T., Gomez M., Gonzales E., Goodstein D., Goodwin L.A., Grady D.L.,
RA Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Hildebrand C.E.,
RA Huang W., Israni S., Jett J., Jewett P.B., Kadner K., Kimball H.,
RA Kobayashi A., Krawczyk M.-C., Leyba T., Longmire J.L., Lopez F., Lou Y.,
RA Lowry S., Ludeman T., Manohar C.F., Mark G.A., McMurray K.L., Meincke L.J.,
RA Morgan J., Moyzis R.K., Mundt M.O., Munk A.C., Nandkeshwar R.D.,
RA Pitluck S., Pollard M., Predki P., Parson-Quintana B., Ramirez L., Rash S.,
RA Retterer J., Ricke D.O., Robinson D.L., Rodriguez A., Salamov A.,
RA Saunders E.H., Scott D., Shough T., Stallings R.L., Stalvey M.,
RA Sutherland R.D., Tapia R., Tesmer J.G., Thayer N., Thompson L.S., Tice H.,
RA Torney D.C., Tran-Gyamfi M., Tsai M., Ulanovsky L.E., Ustaszewska A.,
RA Vo N., White P.S., Williams A.L., Wills P.L., Wu J.-R., Wu K., Yang J.,
RA DeJong P., Bruce D., Doggett N.A., Deaven L., Schmutz J., Grimwood J.,
RA Richardson P., Rokhsar D.S., Eichler E.E., Gilna P., Lucas S.M.,
RA Myers R.M., Rubin E.M., Pennacchio L.A.;
RT "The sequence and analysis of duplication-rich human chromosome 16.";
RL Nature 432:988-994(2004).
RN [2] {ECO:0000313|Ensembl:ENSP00000457550.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=L-arginine(in) + L-cysteine(out) + Na(+)(out) = L-
CC arginine(out) + L-cysteine(in) + Na(+)(in); Xref=Rhea:RHEA:70847,
CC ChEBI:CHEBI:29101, ChEBI:CHEBI:32682, ChEBI:CHEBI:35235;
CC Evidence={ECO:0000256|ARBA:ARBA00036855};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=L-arginine(in) + L-glutamine(out) + Na(+)(out) = L-
CC arginine(out) + L-glutamine(in) + Na(+)(in); Xref=Rhea:RHEA:70835,
CC ChEBI:CHEBI:29101, ChEBI:CHEBI:32682, ChEBI:CHEBI:58359;
CC Evidence={ECO:0000256|ARBA:ARBA00036315};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=L-arginine(in) + L-histidine(out) + Na(+)(out) = L-
CC arginine(out) + L-histidine(in) + Na(+)(in); Xref=Rhea:RHEA:70839,
CC ChEBI:CHEBI:29101, ChEBI:CHEBI:32682, ChEBI:CHEBI:57595;
CC Evidence={ECO:0000256|ARBA:ARBA00036477};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=L-arginine(in) + L-leucine(out) + Na(+)(out) = L-arginine(out)
CC + L-leucine(in) + Na(+)(in); Xref=Rhea:RHEA:70831, ChEBI:CHEBI:29101,
CC ChEBI:CHEBI:32682, ChEBI:CHEBI:57427;
CC Evidence={ECO:0000256|ARBA:ARBA00036563};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=L-arginine(in) + L-lysine(out) = L-arginine(out) + L-
CC lysine(in); Xref=Rhea:RHEA:70827, ChEBI:CHEBI:32551,
CC ChEBI:CHEBI:32682; Evidence={ECO:0000256|ARBA:ARBA00036987};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=L-arginine(in) + L-methionine(out) + Na(+)(out) = L-
CC arginine(out) + L-methionine(in) + Na(+)(in); Xref=Rhea:RHEA:70843,
CC ChEBI:CHEBI:29101, ChEBI:CHEBI:32682, ChEBI:CHEBI:57844;
CC Evidence={ECO:0000256|ARBA:ARBA00035819};
CC -!- SUBUNIT: Disulfide-linked heterodimer with the amino acid transport
CC protein SLC3A2/4F2hc. {ECO:0000256|ARBA:ARBA00038768}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the amino acid-polyamine-organocation (APC)
CC superfamily. L-type amino acid transporter (LAT) (TC 2.A.3.8) family.
CC {ECO:0000256|ARBA:ARBA00007040}.
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DR EMBL; AC020978; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; H3BUA4; -.
DR SMR; H3BUA4; -.
DR MassIVE; H3BUA4; -.
DR MaxQB; H3BUA4; -.
DR PeptideAtlas; H3BUA4; -.
DR ProteomicsDB; 42874; -.
DR Antibodypedia; 55124; 122 antibodies from 18 providers.
DR Ensembl; ENST00000568024.1; ENSP00000457550.1; ENSG00000103064.15.
DR UCSC; uc059weu.1; human.
DR HGNC; HGNC:11064; SLC7A6.
DR VEuPathDB; HostDB:ENSG00000103064; -.
DR GeneTree; ENSGT00940000158295; -.
DR HOGENOM; CLU_164425_0_0_1; -.
DR OMA; QIVFRRR; -.
DR ChiTaRS; SLC7A6; human.
DR Proteomes; UP000005640; Chromosome 16.
DR Bgee; ENSG00000103064; Expressed in apex of heart and 171 other cell types or tissues.
DR ExpressionAtlas; H3BUA4; baseline and differential.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR GO; GO:1902475; P:L-alpha-amino acid transmembrane transport; IEA:UniProt.
DR Gene3D; 1.20.1740.10; Amino acid/polyamine transporter I; 1.
DR InterPro; IPR002293; AA/rel_permease1.
DR PANTHER; PTHR11785; AMINO ACID TRANSPORTER; 1.
DR PANTHER; PTHR11785:SF398; Y+L AMINO ACID TRANSPORTER 2; 1.
DR Pfam; PF13520; AA_permease_2; 1.
PE 1: Evidence at protein level;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Proteomics identification {ECO:0007829|EPD:H3BUA4,
KW ECO:0007829|MaxQB:H3BUA4};
KW Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 45..65
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 77..99
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REGION 1..36
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 13..36
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 123
FT /evidence="ECO:0000313|Ensembl:ENSP00000457550.1"
SQ SEQUENCE 123 AA; 12997 MW; 31A2DD19173947CA CRC64;
MEAREPGRPT PTYHLVPNTS QSQVEEDVSS PPQRSSETMQ LKKEISLLNG VSLVVGNMIG
SGIFVSPKGV LVHTASYGMS LIVWAIGGLF SVVGALCYAE LGTTITKSGA SYAYILEAFG
GFI
//
