ID H3BUC6_HUMAN Unreviewed; 69 AA.
AC H3BUC6;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 1.
DT 27-MAR-2024, entry version 73.
DE RecName: Full=Metallothionein {ECO:0000256|RuleBase:RU000621};
DE Flags: Fragment;
GN Name=MT1M {ECO:0000313|Ensembl:ENSP00000457575.1};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000457575.1, ECO:0000313|Proteomes:UP000005640};
RN [1] {ECO:0000313|Ensembl:ENSP00000457575.1, ECO:0000313|Proteomes:UP000005640}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15616553; DOI=10.1038/nature03187;
RA Martin J., Han C., Gordon L.A., Terry A., Prabhakar S., She X., Xie G.,
RA Hellsten U., Chan Y.M., Altherr M., Couronne O., Aerts A., Bajorek E.,
RA Black S., Blumer H., Branscomb E., Brown N.C., Bruno W.J., Buckingham J.M.,
RA Callen D.F., Campbell C.S., Campbell M.L., Campbell E.W., Caoile C.,
RA Challacombe J.F., Chasteen L.A., Chertkov O., Chi H.C., Christensen M.,
RA Clark L.M., Cohn J.D., Denys M., Detter J.C., Dickson M.,
RA Dimitrijevic-Bussod M., Escobar J., Fawcett J.J., Flowers D., Fotopulos D.,
RA Glavina T., Gomez M., Gonzales E., Goodstein D., Goodwin L.A., Grady D.L.,
RA Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Hildebrand C.E.,
RA Huang W., Israni S., Jett J., Jewett P.B., Kadner K., Kimball H.,
RA Kobayashi A., Krawczyk M.-C., Leyba T., Longmire J.L., Lopez F., Lou Y.,
RA Lowry S., Ludeman T., Manohar C.F., Mark G.A., McMurray K.L., Meincke L.J.,
RA Morgan J., Moyzis R.K., Mundt M.O., Munk A.C., Nandkeshwar R.D.,
RA Pitluck S., Pollard M., Predki P., Parson-Quintana B., Ramirez L., Rash S.,
RA Retterer J., Ricke D.O., Robinson D.L., Rodriguez A., Salamov A.,
RA Saunders E.H., Scott D., Shough T., Stallings R.L., Stalvey M.,
RA Sutherland R.D., Tapia R., Tesmer J.G., Thayer N., Thompson L.S., Tice H.,
RA Torney D.C., Tran-Gyamfi M., Tsai M., Ulanovsky L.E., Ustaszewska A.,
RA Vo N., White P.S., Williams A.L., Wills P.L., Wu J.-R., Wu K., Yang J.,
RA DeJong P., Bruce D., Doggett N.A., Deaven L., Schmutz J., Grimwood J.,
RA Richardson P., Rokhsar D.S., Eichler E.E., Gilna P., Lucas S.M.,
RA Myers R.M., Rubin E.M., Pennacchio L.A.;
RT "The sequence and analysis of duplication-rich human chromosome 16.";
RL Nature 432:988-994(2004).
RN [2] {ECO:0000313|Ensembl:ENSP00000457575.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Metallothioneins have a high content of cysteine residues
CC that bind various heavy metals; these proteins are transcriptionally
CC regulated by both heavy metals and glucocorticoids.
CC {ECO:0000256|ARBA:ARBA00002597}.
CC -!- SIMILARITY: Belongs to the metallothionein superfamily. Type 1 family.
CC {ECO:0000256|ARBA:ARBA00007283, ECO:0000256|RuleBase:RU000621}.
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DR EMBL; AC026461; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; H3BUC6; -.
DR SMR; H3BUC6; -.
DR MassIVE; H3BUC6; -.
DR PeptideAtlas; H3BUC6; -.
DR ProteomicsDB; 42892; -.
DR Antibodypedia; 76223; 30 antibodies from 7 providers.
DR Ensembl; ENST00000570233.1; ENSP00000457575.1; ENSG00000205364.4.
DR UCSC; uc059umg.1; human.
DR HGNC; HGNC:14296; MT1M.
DR VEuPathDB; HostDB:ENSG00000205364; -.
DR GeneTree; ENSGT00950000182967; -.
DR HOGENOM; CLU_2564444_0_0_1; -.
DR PhylomeDB; H3BUC6; -.
DR Proteomes; UP000005640; Chromosome 16.
DR Bgee; ENSG00000205364; Expressed in mucosa of transverse colon and 165 other cell types or tissues.
DR ExpressionAtlas; H3BUC6; baseline and differential.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0070887; P:cellular response to chemical stimulus; IEA:UniProt.
DR GO; GO:0010035; P:response to inorganic substance; IEA:UniProt.
DR Gene3D; 4.10.10.10; Metallothionein Isoform II; 1.
DR InterPro; IPR017854; Metalthion_dom_sf.
DR InterPro; IPR023587; Metalthion_dom_sf_vert.
DR InterPro; IPR000006; Metalthion_vert.
DR InterPro; IPR018064; Metalthion_vert_metal_BS.
DR PANTHER; PTHR23299; METALLOTHIONEIN; 1.
DR PANTHER; PTHR23299:SF63; METALLOTHIONEIN 1H-LIKE PROTEIN 1-RELATED; 1.
DR Pfam; PF00131; Metallothio; 1.
DR SUPFAM; SSF57868; Metallothionein; 1.
DR PROSITE; PS00203; METALLOTHIONEIN_VRT; 1.
PE 1: Evidence at protein level;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW ECO:0000256|RuleBase:RU000621};
KW Metal-thiolate cluster {ECO:0000256|ARBA:ARBA00022851,
KW ECO:0000256|RuleBase:RU000621};
KW Proteomics identification {ECO:0007829|PeptideAtlas:H3BUC6,
KW ECO:0007829|ProteomicsDB:H3BUC6};
KW Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW Zinc {ECO:0000256|ARBA:ARBA00022833}.
FT NON_TER 69
FT /evidence="ECO:0000313|Ensembl:ENSP00000457575.1"
SQ SEQUENCE 69 AA; 7137 MW; 0478F33D1787F512 CRC64;
MDPNCSCTTG VSCACTGSCT CKECKCTSCK KSECGAISRN LGLWLRLGGN PRLALSASFW
GTGLSLPSL
//
