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Database: UniProt
Entry: H3BX13_TETNG
LinkDB: H3BX13_TETNG
Original site: H3BX13_TETNG 
ID   H3BX13_TETNG            Unreviewed;       227 AA.
AC   H3BX13;
DT   18-APR-2012, integrated into UniProtKB/TrEMBL.
DT   18-APR-2012, sequence version 1.
DT   24-JAN-2024, entry version 52.
DE   RecName: Full=Interleukin-6 {ECO:0000256|ARBA:ARBA00019464};
OS   Tetraodon nigroviridis (Spotted green pufferfish) (Chelonodon
OS   nigroviridis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Tetraodon.
OX   NCBI_TaxID=99883 {ECO:0000313|Ensembl:ENSTNIP00000000526.1, ECO:0000313|Proteomes:UP000007303};
RN   [1] {ECO:0000313|Proteomes:UP000007303}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15496914; DOI=10.1038/nature03025;
RA   Jaillon O., Aury J.-M., Brunet F., Petit J.-L., Stange-Thomann N.,
RA   Mauceli E., Bouneau L., Fischer C., Ozouf-Costaz C., Bernot A., Nicaud S.,
RA   Jaffe D., Fisher S., Lutfalla G., Dossat C., Segurens B., Dasilva C.,
RA   Salanoubat M., Levy M., Boudet N., Castellano S., Anthouard V., Jubin C.,
RA   Castelli V., Katinka M., Vacherie B., Biemont C., Skalli Z., Cattolico L.,
RA   Poulain J., De Berardinis V., Cruaud C., Duprat S., Brottier P.,
RA   Coutanceau J.-P., Gouzy J., Parra G., Lardier G., Chapple C.,
RA   McKernan K.J., McEwan P., Bosak S., Kellis M., Volff J.-N., Guigo R.,
RA   Zody M.C., Mesirov J., Lindblad-Toh K., Birren B., Nusbaum C., Kahn D.,
RA   Robinson-Rechavi M., Laudet V., Schachter V., Quetier F., Saurin W.,
RA   Scarpelli C., Wincker P., Lander E.S., Weissenbach J., Roest Crollius H.;
RT   "Genome duplication in the teleost fish Tetraodon nigroviridis reveals the
RT   early vertebrate proto-karyotype.";
RL   Nature 431:946-957(2004).
RN   [2] {ECO:0000313|Ensembl:ENSTNIP00000000526.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC   -!- SIMILARITY: Belongs to the IL-6 superfamily.
CC       {ECO:0000256|ARBA:ARBA00007432}.
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DR   AlphaFoldDB; H3BX13; -.
DR   STRING; 99883.ENSTNIP00000000526; -.
DR   Ensembl; ENSTNIT00000002432.1; ENSTNIP00000000526.1; ENSTNIG00000002544.1.
DR   GeneTree; ENSGT00390000000878; -.
DR   InParanoid; H3BX13; -.
DR   OMA; DFLVEWK; -.
DR   TreeFam; TF335984; -.
DR   Proteomes; UP000007303; Unassembled WGS sequence.
DR   GO; GO:0005615; C:extracellular space; IEA:InterPro.
DR   GO; GO:0005125; F:cytokine activity; IEA:InterPro.
DR   GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
DR   GO; GO:0005138; F:interleukin-6 receptor binding; IEA:InterPro.
DR   GO; GO:0006953; P:acute-phase response; IEA:UniProtKB-KW.
DR   GO; GO:0072540; P:T-helper 17 cell lineage commitment; IEA:InterPro.
DR   Gene3D; 1.20.1250.10; -; 1.
DR   InterPro; IPR009079; 4_helix_cytokine-like_core.
DR   InterPro; IPR003574; IL-6.
DR   InterPro; IPR030474; IL-6/GCSF/MGF.
DR   InterPro; IPR030473; IL6/GCSF/MGF_CS.
DR   PANTHER; PTHR10511; GRANULOCYTE COLONY-STIMULATING FACTOR; 1.
DR   PANTHER; PTHR10511:SF2; GRANULOCYTE COLONY-STIMULATING FACTOR; 1.
DR   Pfam; PF00489; IL6; 1.
DR   SUPFAM; SSF47266; 4-helical cytokines; 1.
DR   PROSITE; PS00254; INTERLEUKIN_6; 1.
PE   3: Inferred from homology;
KW   Acute phase {ECO:0000256|ARBA:ARBA00022486};
KW   Reference proteome {ECO:0000313|Proteomes:UP000007303};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL          1..22
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           23..227
FT                   /note="Interleukin-6"
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5003581136"
FT   REGION          25..45
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   227 AA;  25902 MW;  72870E24DB7FA850 CRC64;
     MSLFTNLLPP LLLAAALRLA AGAPLEGPTE SPAGETSGEE LETGRPEDAL AVALESVLRA
     TKRHKKEFLA EFQGEVKYEF LDRYKIPSLP AKCPYSNFGQ DACLRRLLEG LLVYSVLLKH
     VEQEYPLSRI SEVRYYSNVL IKEVENKVKE RGQVTTLSSS QQEQLLRAVD RSDTFHRRMT
     AHGILYNLHY FLVDCRRVIV NKKKKKKKDT GAHVTKVIFL YHMKKKK
//
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