ID H3BX70_TETNG Unreviewed; 456 AA.
AC H3BX70;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 1.
DT 27-MAR-2024, entry version 53.
DE RecName: Full=Hyaluronidase {ECO:0000256|RuleBase:RU610713};
DE EC=3.2.1.35 {ECO:0000256|RuleBase:RU610713};
GN Name=HYAL4 {ECO:0000313|Ensembl:ENSTNIP00000000583.1};
OS Tetraodon nigroviridis (Spotted green pufferfish) (Chelonodon
OS nigroviridis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Tetraodon.
OX NCBI_TaxID=99883 {ECO:0000313|Ensembl:ENSTNIP00000000583.1, ECO:0000313|Proteomes:UP000007303};
RN [1] {ECO:0000313|Proteomes:UP000007303}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15496914; DOI=10.1038/nature03025;
RA Jaillon O., Aury J.-M., Brunet F., Petit J.-L., Stange-Thomann N.,
RA Mauceli E., Bouneau L., Fischer C., Ozouf-Costaz C., Bernot A., Nicaud S.,
RA Jaffe D., Fisher S., Lutfalla G., Dossat C., Segurens B., Dasilva C.,
RA Salanoubat M., Levy M., Boudet N., Castellano S., Anthouard V., Jubin C.,
RA Castelli V., Katinka M., Vacherie B., Biemont C., Skalli Z., Cattolico L.,
RA Poulain J., De Berardinis V., Cruaud C., Duprat S., Brottier P.,
RA Coutanceau J.-P., Gouzy J., Parra G., Lardier G., Chapple C.,
RA McKernan K.J., McEwan P., Bosak S., Kellis M., Volff J.-N., Guigo R.,
RA Zody M.C., Mesirov J., Lindblad-Toh K., Birren B., Nusbaum C., Kahn D.,
RA Robinson-Rechavi M., Laudet V., Schachter V., Quetier F., Saurin W.,
RA Scarpelli C., Wincker P., Lander E.S., Weissenbach J., Roest Crollius H.;
RT "Genome duplication in the teleost fish Tetraodon nigroviridis reveals the
RT early vertebrate proto-karyotype.";
RL Nature 431:946-957(2004).
RN [2] {ECO:0000313|Ensembl:ENSTNIP00000000583.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Random hydrolysis of (1->4)-linkages between N-acetyl-beta-D-
CC glucosamine and D-glucuronate residues in hyaluronate.; EC=3.2.1.35;
CC Evidence={ECO:0000256|ARBA:ARBA00000251,
CC ECO:0000256|RuleBase:RU610713};
CC -!- SIMILARITY: Belongs to the glycosyl hydrolase 56 family.
CC {ECO:0000256|ARBA:ARBA00008871, ECO:0000256|PIRNR:PIRNR038193,
CC ECO:0000256|RuleBase:RU610713}.
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DR AlphaFoldDB; H3BX70; -.
DR STRING; 99883.ENSTNIP00000000583; -.
DR Ensembl; ENSTNIT00000002654.1; ENSTNIP00000000583.1; ENSTNIG00000000981.1.
DR GeneTree; ENSGT01020000230364; -.
DR InParanoid; H3BX70; -.
DR TreeFam; TF321598; -.
DR Proteomes; UP000007303; Unassembled WGS sequence.
DR GO; GO:0004415; F:hyalurononglucosaminidase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0005975; P:carbohydrate metabolic process; IEA:UniProtKB-UniRule.
DR Gene3D; 3.20.20.70; Aldolase class I; 1.
DR InterPro; IPR013785; Aldolase_TIM.
DR InterPro; IPR017853; Glycoside_hydrolase_SF.
DR InterPro; IPR018155; Hyaluronidase.
DR PANTHER; PTHR11769; HYALURONIDASE; 1.
DR PANTHER; PTHR11769:SF7; HYALURONIDASE-4; 1.
DR Pfam; PF01630; Glyco_hydro_56; 1.
DR PIRSF; PIRSF038193; Hyaluronidase; 1.
DR PRINTS; PR00846; GLHYDRLASE56.
DR PRINTS; PR00848; SPERMPH20.
DR SUPFAM; SSF51445; (Trans)glycosidases; 1.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|PIRSR:PIRSR038193-3};
KW Glycosidase {ECO:0000256|ARBA:ARBA00023295, ECO:0000256|RuleBase:RU610713};
KW Hydrolase {ECO:0000256|RuleBase:RU610713};
KW Reference proteome {ECO:0000313|Proteomes:UP000007303};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..15
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 16..456
FT /note="Hyaluronidase"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5012858916"
FT ACT_SITE 126
FT /note="Proton donor"
FT /evidence="ECO:0000256|PIRSR:PIRSR038193-1"
FT CARBOHYD 347
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000256|PIRSR:PIRSR038193-2"
FT DISULFID 37..330
FT /evidence="ECO:0000256|PIRSR:PIRSR038193-3"
FT DISULFID 202..216
FT /evidence="ECO:0000256|PIRSR:PIRSR038193-3"
FT DISULFID 355..366
FT /evidence="ECO:0000256|PIRSR:PIRSR038193-3"
FT DISULFID 360..414
FT /evidence="ECO:0000256|PIRSR:PIRSR038193-3"
FT DISULFID 416..425
FT /evidence="ECO:0000256|PIRSR:PIRSR038193-3"
SQ SEQUENCE 456 AA; 52413 MW; 8E96AEABA7C2EEAD CRC64;
SWLLLLLHAA SGHKAARLPL IGRKPFIAAW NAPLDRCTTR YNISTNVERL FHIQGSPRAE
WTGQNITIFY ANRLGFYPHY TPQGVAVNGG LPQNCSLDLH LLKAHQDIRR FIPARDVRGL
AVIDWEFWRP QWKRNWHKKV IYRRRSKELT ARAYGNVTEA QVEELARRRF EKSAKAFMQQ
TLQLGTRLRP NTLWGFYLYP DCHNYNLEQQ NYTGLCPLLE RRRNDELRWL WNSSSALFPS
VAIRRDHSDS ASNRHFSQHR IREALRVASL TSREYQLPTF VYLRLGYRDE ALTFLSAKDL
VHTIGESAAL GAAGFVIWGD LNLTSSRLNC SRVRSFLRHR LGRYITNVTR AAEFCSDFLC
QGNGRCVRRD PRAHHYLHLS GRSHRIRLSD DGAFAVSGGP SQQELRLLPR RFRCHCYEGH
EGERCDSCSG AVSTGPGLEL VALALLLLHL LTTTVQ
//