ID H3BXS4_TETNG Unreviewed; 848 AA.
AC H3BXS4;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 1.
DT 24-JAN-2024, entry version 69.
DE SubName: Full=Leucine rich repeat containing 8 VRAC subunit Da {ECO:0000313|Ensembl:ENSTNIP00000000787.1};
OS Tetraodon nigroviridis (Spotted green pufferfish) (Chelonodon
OS nigroviridis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Tetraodon.
OX NCBI_TaxID=99883 {ECO:0000313|Ensembl:ENSTNIP00000000787.1, ECO:0000313|Proteomes:UP000007303};
RN [1] {ECO:0000313|Proteomes:UP000007303}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15496914; DOI=10.1038/nature03025;
RA Jaillon O., Aury J.-M., Brunet F., Petit J.-L., Stange-Thomann N.,
RA Mauceli E., Bouneau L., Fischer C., Ozouf-Costaz C., Bernot A., Nicaud S.,
RA Jaffe D., Fisher S., Lutfalla G., Dossat C., Segurens B., Dasilva C.,
RA Salanoubat M., Levy M., Boudet N., Castellano S., Anthouard V., Jubin C.,
RA Castelli V., Katinka M., Vacherie B., Biemont C., Skalli Z., Cattolico L.,
RA Poulain J., De Berardinis V., Cruaud C., Duprat S., Brottier P.,
RA Coutanceau J.-P., Gouzy J., Parra G., Lardier G., Chapple C.,
RA McKernan K.J., McEwan P., Bosak S., Kellis M., Volff J.-N., Guigo R.,
RA Zody M.C., Mesirov J., Lindblad-Toh K., Birren B., Nusbaum C., Kahn D.,
RA Robinson-Rechavi M., Laudet V., Schachter V., Quetier F., Saurin W.,
RA Scarpelli C., Wincker P., Lander E.S., Weissenbach J., Roest Crollius H.;
RT "Genome duplication in the teleost fish Tetraodon nigroviridis reveals the
RT early vertebrate proto-karyotype.";
RL Nature 431:946-957(2004).
RN [2] {ECO:0000313|Ensembl:ENSTNIP00000000787.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (JUL-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=chloride(in) = chloride(out); Xref=Rhea:RHEA:29823,
CC ChEBI:CHEBI:17996; Evidence={ECO:0000256|ARBA:ARBA00024167};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=iodide(out) = iodide(in); Xref=Rhea:RHEA:66324,
CC ChEBI:CHEBI:16382; Evidence={ECO:0000256|ARBA:ARBA00024145};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=taurine(out) = taurine(in); Xref=Rhea:RHEA:66328,
CC ChEBI:CHEBI:507393; Evidence={ECO:0000256|ARBA:ARBA00024158};
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the LRRC8 family.
CC {ECO:0000256|ARBA:ARBA00010471}.
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DR AlphaFoldDB; H3BXS4; -.
DR STRING; 99883.ENSTNIP00000000787; -.
DR Ensembl; ENSTNIT00000003594.1; ENSTNIP00000000787.1; ENSTNIG00000001498.1.
DR GeneTree; ENSGT00940000159311; -.
DR HOGENOM; CLU_019019_0_0_1; -.
DR InParanoid; H3BXS4; -.
DR OMA; KFFCTHN; -.
DR TreeFam; TF331443; -.
DR Proteomes; UP000007303; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0034220; P:monoatomic ion transmembrane transport; IEA:UniProtKB-KW.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 1.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR021040; LRRC8_Pannexin-like.
DR PANTHER; PTHR48051; -; 1.
DR PANTHER; PTHR48051:SF3; LEUCINE RICH REPEAT CONTAINING 8 VRAC SUBUNIT A; 1.
DR Pfam; PF13855; LRR_8; 3.
DR Pfam; PF12534; Pannexin_like; 1.
DR SMART; SM00365; LRR_SD22; 3.
DR SMART; SM00369; LRR_TYP; 8.
DR SUPFAM; SSF52058; L domain-like; 1.
DR PROSITE; PS51450; LRR; 3.
PE 3: Inferred from homology;
KW Ion channel {ECO:0000256|ARBA:ARBA00023303};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000007303};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius};
KW Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 27..47
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 156..176
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 358..380
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 1..376
FT /note="LRRC8 pannexin-like TM region"
FT /evidence="ECO:0000259|Pfam:PF12534"
FT REGION 211..244
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 219..244
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 848 AA; 97020 MW; ABFDE43098E4E14E CRC64;
MFTLTEVASL NDIQPTYRIL KPWWDVLMDY LGLVMLMLAI FGMTMQITKD HMACLPCLED
PQGDLGATGE FFTEETTEAP PASSATLFTS APTVTKDLPD SAVHEIHSTH QQTSVASGRY
VTQPLPTGVK TNLDFQQYAF VNQMCYHVAL PWYSKYFSYL TLIHTLVLMV SSNFWFKYPK
TCSKIEHFVS ILGRCFESPW TTKALSETAC EDSEENKQRL TGSSATQKQV SMEGSDEASN
ANSSTPMLEM RFSADKPLAE VPSSMTILDK KDGEQAKALF EKVRKFRVHV EDSDLIYKLY
VAQTMVKTVK FILILSYTST FLAKINFKHM CEPDIKQLTG YKRFFCTHNM AYMLNKLLIS
YMALILIYGM ACLYALFWVF RRPLKEYSFE KVREESSFSD IPDVKNDFAF LLHMVDQYDQ
LYSKRFGVFL SEVSENKLRE ISLNHEWTFE KVRQLVSRNA QDQQELHLFM LSGLPNAVFD
LTDLEVLRLE LIPEVRFSAK VSQMTSLREL HLCHCPAKVE QTGFTFLRDH LRCLHVKFTD
VAEIPAWVYL LRSLRELNLI GNLSSENNKM IGLESMRDLR HLKTLCLKSN LTKMPTNITE
LSPHLIRLVV HNDGTKLMVL NSLKKMINLI ELELHNCELE RIPHAIFSLT NLQELDLKSN
SIRTIEEIIS FQHLKRLTCL KLWHNKIITI PPSISQVRSL EALHLSHNKL ESLSPALFTL
PKLRHLDLSH NAIPTLPPDV GLLHNLQYLA LNSNKLELLP KTLFRCTKLK VLLLGNNALT
AFPESVGQLI QLAQLELRGN CLDRLPVQLG SCRMLRKNGL LVEDHLFDAL PVETKESINK
ESTFTSGL
//