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Database: UniProt
Entry: H3BXS4_TETNG
LinkDB: H3BXS4_TETNG
Original site: H3BXS4_TETNG 
ID   H3BXS4_TETNG            Unreviewed;       848 AA.
AC   H3BXS4;
DT   18-APR-2012, integrated into UniProtKB/TrEMBL.
DT   18-APR-2012, sequence version 1.
DT   24-JAN-2024, entry version 69.
DE   SubName: Full=Leucine rich repeat containing 8 VRAC subunit Da {ECO:0000313|Ensembl:ENSTNIP00000000787.1};
OS   Tetraodon nigroviridis (Spotted green pufferfish) (Chelonodon
OS   nigroviridis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Tetraodon.
OX   NCBI_TaxID=99883 {ECO:0000313|Ensembl:ENSTNIP00000000787.1, ECO:0000313|Proteomes:UP000007303};
RN   [1] {ECO:0000313|Proteomes:UP000007303}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15496914; DOI=10.1038/nature03025;
RA   Jaillon O., Aury J.-M., Brunet F., Petit J.-L., Stange-Thomann N.,
RA   Mauceli E., Bouneau L., Fischer C., Ozouf-Costaz C., Bernot A., Nicaud S.,
RA   Jaffe D., Fisher S., Lutfalla G., Dossat C., Segurens B., Dasilva C.,
RA   Salanoubat M., Levy M., Boudet N., Castellano S., Anthouard V., Jubin C.,
RA   Castelli V., Katinka M., Vacherie B., Biemont C., Skalli Z., Cattolico L.,
RA   Poulain J., De Berardinis V., Cruaud C., Duprat S., Brottier P.,
RA   Coutanceau J.-P., Gouzy J., Parra G., Lardier G., Chapple C.,
RA   McKernan K.J., McEwan P., Bosak S., Kellis M., Volff J.-N., Guigo R.,
RA   Zody M.C., Mesirov J., Lindblad-Toh K., Birren B., Nusbaum C., Kahn D.,
RA   Robinson-Rechavi M., Laudet V., Schachter V., Quetier F., Saurin W.,
RA   Scarpelli C., Wincker P., Lander E.S., Weissenbach J., Roest Crollius H.;
RT   "Genome duplication in the teleost fish Tetraodon nigroviridis reveals the
RT   early vertebrate proto-karyotype.";
RL   Nature 431:946-957(2004).
RN   [2] {ECO:0000313|Ensembl:ENSTNIP00000000787.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2023) to UniProtKB.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=chloride(in) = chloride(out); Xref=Rhea:RHEA:29823,
CC         ChEBI:CHEBI:17996; Evidence={ECO:0000256|ARBA:ARBA00024167};
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=iodide(out) = iodide(in); Xref=Rhea:RHEA:66324,
CC         ChEBI:CHEBI:16382; Evidence={ECO:0000256|ARBA:ARBA00024145};
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=taurine(out) = taurine(in); Xref=Rhea:RHEA:66328,
CC         ChEBI:CHEBI:507393; Evidence={ECO:0000256|ARBA:ARBA00024158};
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC       Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC       {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the LRRC8 family.
CC       {ECO:0000256|ARBA:ARBA00010471}.
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DR   AlphaFoldDB; H3BXS4; -.
DR   STRING; 99883.ENSTNIP00000000787; -.
DR   Ensembl; ENSTNIT00000003594.1; ENSTNIP00000000787.1; ENSTNIG00000001498.1.
DR   GeneTree; ENSGT00940000159311; -.
DR   HOGENOM; CLU_019019_0_0_1; -.
DR   InParanoid; H3BXS4; -.
DR   OMA; KFFCTHN; -.
DR   TreeFam; TF331443; -.
DR   Proteomes; UP000007303; Unassembled WGS sequence.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0034220; P:monoatomic ion transmembrane transport; IEA:UniProtKB-KW.
DR   Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 1.
DR   InterPro; IPR001611; Leu-rich_rpt.
DR   InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR   InterPro; IPR032675; LRR_dom_sf.
DR   InterPro; IPR021040; LRRC8_Pannexin-like.
DR   PANTHER; PTHR48051; -; 1.
DR   PANTHER; PTHR48051:SF3; LEUCINE RICH REPEAT CONTAINING 8 VRAC SUBUNIT A; 1.
DR   Pfam; PF13855; LRR_8; 3.
DR   Pfam; PF12534; Pannexin_like; 1.
DR   SMART; SM00365; LRR_SD22; 3.
DR   SMART; SM00369; LRR_TYP; 8.
DR   SUPFAM; SSF52058; L domain-like; 1.
DR   PROSITE; PS51450; LRR; 3.
PE   3: Inferred from homology;
KW   Ion channel {ECO:0000256|ARBA:ARBA00023303};
KW   Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW   Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000007303};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius};
KW   Transport {ECO:0000256|ARBA:ARBA00022448}.
FT   TRANSMEM        27..47
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        156..176
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        358..380
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          1..376
FT                   /note="LRRC8 pannexin-like TM region"
FT                   /evidence="ECO:0000259|Pfam:PF12534"
FT   REGION          211..244
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        219..244
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   848 AA;  97020 MW;  ABFDE43098E4E14E CRC64;
     MFTLTEVASL NDIQPTYRIL KPWWDVLMDY LGLVMLMLAI FGMTMQITKD HMACLPCLED
     PQGDLGATGE FFTEETTEAP PASSATLFTS APTVTKDLPD SAVHEIHSTH QQTSVASGRY
     VTQPLPTGVK TNLDFQQYAF VNQMCYHVAL PWYSKYFSYL TLIHTLVLMV SSNFWFKYPK
     TCSKIEHFVS ILGRCFESPW TTKALSETAC EDSEENKQRL TGSSATQKQV SMEGSDEASN
     ANSSTPMLEM RFSADKPLAE VPSSMTILDK KDGEQAKALF EKVRKFRVHV EDSDLIYKLY
     VAQTMVKTVK FILILSYTST FLAKINFKHM CEPDIKQLTG YKRFFCTHNM AYMLNKLLIS
     YMALILIYGM ACLYALFWVF RRPLKEYSFE KVREESSFSD IPDVKNDFAF LLHMVDQYDQ
     LYSKRFGVFL SEVSENKLRE ISLNHEWTFE KVRQLVSRNA QDQQELHLFM LSGLPNAVFD
     LTDLEVLRLE LIPEVRFSAK VSQMTSLREL HLCHCPAKVE QTGFTFLRDH LRCLHVKFTD
     VAEIPAWVYL LRSLRELNLI GNLSSENNKM IGLESMRDLR HLKTLCLKSN LTKMPTNITE
     LSPHLIRLVV HNDGTKLMVL NSLKKMINLI ELELHNCELE RIPHAIFSLT NLQELDLKSN
     SIRTIEEIIS FQHLKRLTCL KLWHNKIITI PPSISQVRSL EALHLSHNKL ESLSPALFTL
     PKLRHLDLSH NAIPTLPPDV GLLHNLQYLA LNSNKLELLP KTLFRCTKLK VLLLGNNALT
     AFPESVGQLI QLAQLELRGN CLDRLPVQLG SCRMLRKNGL LVEDHLFDAL PVETKESINK
     ESTFTSGL
//
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