ID H3BZ46_TETNG Unreviewed; 930 AA.
AC H3BZ46;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 1.
DT 27-MAR-2024, entry version 51.
DE SubName: Full=Si:ch73-335l21.1 {ECO:0000313|Ensembl:ENSTNIP00000001262.1};
OS Tetraodon nigroviridis (Spotted green pufferfish) (Chelonodon
OS nigroviridis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Tetraodon.
OX NCBI_TaxID=99883 {ECO:0000313|Ensembl:ENSTNIP00000001262.1, ECO:0000313|Proteomes:UP000007303};
RN [1] {ECO:0000313|Proteomes:UP000007303}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15496914; DOI=10.1038/nature03025;
RA Jaillon O., Aury J.-M., Brunet F., Petit J.-L., Stange-Thomann N.,
RA Mauceli E., Bouneau L., Fischer C., Ozouf-Costaz C., Bernot A., Nicaud S.,
RA Jaffe D., Fisher S., Lutfalla G., Dossat C., Segurens B., Dasilva C.,
RA Salanoubat M., Levy M., Boudet N., Castellano S., Anthouard V., Jubin C.,
RA Castelli V., Katinka M., Vacherie B., Biemont C., Skalli Z., Cattolico L.,
RA Poulain J., De Berardinis V., Cruaud C., Duprat S., Brottier P.,
RA Coutanceau J.-P., Gouzy J., Parra G., Lardier G., Chapple C.,
RA McKernan K.J., McEwan P., Bosak S., Kellis M., Volff J.-N., Guigo R.,
RA Zody M.C., Mesirov J., Lindblad-Toh K., Birren B., Nusbaum C., Kahn D.,
RA Robinson-Rechavi M., Laudet V., Schachter V., Quetier F., Saurin W.,
RA Scarpelli C., Wincker P., Lander E.S., Weissenbach J., Roest Crollius H.;
RT "Genome duplication in the teleost fish Tetraodon nigroviridis reveals the
RT early vertebrate proto-karyotype.";
RL Nature 431:946-957(2004).
RN [2] {ECO:0000313|Ensembl:ENSTNIP00000001262.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR AlphaFoldDB; H3BZ46; -.
DR Ensembl; ENSTNIT00000001292.1; ENSTNIP00000001262.1; ENSTNIG00000002043.1.
DR GeneTree; ENSGT00940000166370; -.
DR HOGENOM; CLU_004902_2_1_1; -.
DR Proteomes; UP000007303; Unassembled WGS sequence.
DR GO; GO:0005158; F:insulin receptor binding; IEA:InterPro.
DR GO; GO:0008286; P:insulin receptor signaling pathway; IEA:InterPro.
DR CDD; cd01257; PH_IRS; 1.
DR CDD; cd01204; PTB_IRS; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 2.
DR InterPro; IPR039011; IRS.
DR InterPro; IPR002404; IRS_PTB.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR PANTHER; PTHR10614; INSULIN RECEPTOR SUBSTRATE; 1.
DR PANTHER; PTHR10614:SF8; INSULIN RECEPTOR SUBSTRATE 3; 1.
DR Pfam; PF02174; IRS; 1.
DR Pfam; PF00169; PH; 1.
DR PRINTS; PR00628; INSULINRSI.
DR SMART; SM01244; IRS; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00310; PTBI; 1.
DR SUPFAM; SSF50729; PH domain-like; 2.
DR PROSITE; PS51064; IRS_PTB; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000007303}.
FT DOMAIN 11..113
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 154..258
FT /note="IRS-type PTB"
FT /evidence="ECO:0000259|PROSITE:PS51064"
FT REGION 256..571
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 709..755
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 789..930
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 260..284
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 314..330
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 351..380
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 395..413
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 422..525
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 527..543
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 718..733
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 789..811
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 837..852
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 930 AA; 97126 MW; 7617F900D37A6C36 CRC64;
MESPAGDSCE DVRRSGYLRK QKSMHRRYFV LRAASERGPA RLEYYESEKK FRGKAPVPKK
AVALETCFNI NKRADSKNKH MIVLYTRAES LALAAESEAD QDDWFQALVE LQCKRAPVQS
GTPGGVGGSV SAGKNPSDGG ALGDYGVPNP GPAFKEVWQV KVWPKGLGQA KNLVGIYRLC
LTEKTVNFVK LNSDAAAVVL QLMNVRRCGH SENFFFVEVG RSAVTGPGEF WMQVEDSVVA
QNMHETLLEA MKALSEEFRQ RSKSQSNSGP GGGATASNPI SVPSRRHHPN PPPSQVGFTR
RPRTEPPGAN GGAGVNSASA SPTPRHSFPR SRTASDGAKV EEGLVGATPL QGPCSSPSAN
GACSTTPILR SKSARSAPTA TTKAPLGLMR SISTPAPSPA PSLSSSSGHG SEFGGITPSA
CTGPSGAYSR IPSHHTSISG SPSDYGSSDE YGSSPGDHTL LPSPSLPGSS VGSSGSQSLG
EEAANYILMS QRRNSVEGGG GTQGASTSLP ASATPTCGSH PQSRRMLRRS SSRESEAERR
LLSKRASLPP MALERLAPHQ RRAEEPADED SADYAIMSRN TSHESFHSSS AKQRESALSA
GSAATGGAYL DVAGELKSEA AGGGPVDNGY MSMLPGVTQP PVSLAQSLAV SVPDSDSKPA
DDYMAMTPNN SVSPPQQIRP PLTSDGYMIM SPNSSCSPDQ RACLSGGAWV GSGSADSRAG
SDYMNMSPIS ARSVNGSPPP PDHAGPSESS SQQQAPKMVY SYYSLPRSYK HNPTTGHFDD
CPGRGRRHNH LSFSSSSYSS SSASSESLGD NEAGASGAAP GGTPSKDGGK LQQRHGSGGL
PKQSSHTKSR PVSLFVDVSK ANTLPRVREN PLPPEPKSPG EYVSIEFKGV GSGQAGPGGG
CGNFMPLSRS PSAPITPPAV SEYVNMDLGP
//
