ID H3C0I8_TETNG Unreviewed; 785 AA.
AC H3C0I8;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 1.
DT 27-MAR-2024, entry version 68.
DE RecName: Full=Integrin beta {ECO:0000256|RuleBase:RU000633};
OS Tetraodon nigroviridis (Spotted green pufferfish) (Chelonodon
OS nigroviridis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Tetraodon.
OX NCBI_TaxID=99883 {ECO:0000313|Ensembl:ENSTNIP00000001754.1, ECO:0000313|Proteomes:UP000007303};
RN [1] {ECO:0000313|Proteomes:UP000007303}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15496914; DOI=10.1038/nature03025;
RA Jaillon O., Aury J.-M., Brunet F., Petit J.-L., Stange-Thomann N.,
RA Mauceli E., Bouneau L., Fischer C., Ozouf-Costaz C., Bernot A., Nicaud S.,
RA Jaffe D., Fisher S., Lutfalla G., Dossat C., Segurens B., Dasilva C.,
RA Salanoubat M., Levy M., Boudet N., Castellano S., Anthouard V., Jubin C.,
RA Castelli V., Katinka M., Vacherie B., Biemont C., Skalli Z., Cattolico L.,
RA Poulain J., De Berardinis V., Cruaud C., Duprat S., Brottier P.,
RA Coutanceau J.-P., Gouzy J., Parra G., Lardier G., Chapple C.,
RA McKernan K.J., McEwan P., Bosak S., Kellis M., Volff J.-N., Guigo R.,
RA Zody M.C., Mesirov J., Lindblad-Toh K., Birren B., Nusbaum C., Kahn D.,
RA Robinson-Rechavi M., Laudet V., Schachter V., Quetier F., Saurin W.,
RA Scarpelli C., Wincker P., Lander E.S., Weissenbach J., Roest Crollius H.;
RT "Genome duplication in the teleost fish Tetraodon nigroviridis reveals the
RT early vertebrate proto-karyotype.";
RL Nature 431:946-957(2004).
RN [2] {ECO:0000313|Ensembl:ENSTNIP00000001754.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004251,
CC ECO:0000256|RuleBase:RU000633}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004251, ECO:0000256|RuleBase:RU000633}.
CC Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane
CC protein {ECO:0000256|ARBA:ARBA00004479}.
CC -!- SIMILARITY: Belongs to the integrin beta chain family.
CC {ECO:0000256|ARBA:ARBA00007449, ECO:0000256|RuleBase:RU000633}.
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DR AlphaFoldDB; H3C0I8; -.
DR STRING; 99883.ENSTNIP00000001754; -.
DR Ensembl; ENSTNIT00000000199.1; ENSTNIP00000001754.1; ENSTNIG00000011722.1.
DR GeneTree; ENSGT01090000259987; -.
DR InParanoid; H3C0I8; -.
DR OMA; THTTHFR; -.
DR TreeFam; TF105392; -.
DR Proteomes; UP000007303; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
DR GO; GO:0007229; P:integrin-mediated signaling pathway; IEA:UniProtKB-KW.
DR Gene3D; 4.10.1240.30; -; 1.
DR Gene3D; 1.20.5.100; Cytochrome c1, transmembrane anchor, C-terminal; 1.
DR Gene3D; 2.10.25.10; Laminin; 3.
DR Gene3D; 3.30.1680.10; ligand-binding face of the semaphorins, domain 2; 1.
DR Gene3D; 2.60.40.1510; ntegrin, alpha v. Chain A, domain 3; 1.
DR Gene3D; 3.40.50.410; von Willebrand factor, type A domain; 1.
DR InterPro; IPR013111; EGF_extracell.
DR InterPro; IPR040622; I-EGF_1.
DR InterPro; IPR033760; Integrin_beta_N.
DR InterPro; IPR015812; Integrin_bsu.
DR InterPro; IPR014836; Integrin_bsu_cyt_dom.
DR InterPro; IPR012896; Integrin_bsu_tail.
DR InterPro; IPR036349; Integrin_bsu_tail_dom_sf.
DR InterPro; IPR002369; Integrin_bsu_VWA.
DR InterPro; IPR032695; Integrin_dom_sf.
DR InterPro; IPR016201; PSI.
DR InterPro; IPR036465; vWFA_dom_sf.
DR PANTHER; PTHR10082; INTEGRIN BETA SUBUNIT; 1.
DR PANTHER; PTHR10082:SF25; INTEGRIN BETA-3; 1.
DR Pfam; PF07974; EGF_2; 2.
DR Pfam; PF18372; I-EGF_1; 1.
DR Pfam; PF08725; Integrin_b_cyt; 1.
DR Pfam; PF07965; Integrin_B_tail; 1.
DR Pfam; PF00362; Integrin_beta; 1.
DR Pfam; PF17205; PSI_integrin; 1.
DR PIRSF; PIRSF002512; Integrin_B; 1.
DR PRINTS; PR01186; INTEGRINB.
DR SMART; SM00187; INB; 1.
DR SMART; SM01241; Integrin_b_cyt; 1.
DR SMART; SM01242; Integrin_B_tail; 1.
DR SMART; SM00423; PSI; 1.
DR SUPFAM; SSF57196; EGF/Laminin; 2.
DR SUPFAM; SSF69687; Integrin beta tail domain; 1.
DR SUPFAM; SSF69179; Integrin domains; 1.
DR SUPFAM; SSF103575; Plexin repeat; 1.
DR SUPFAM; SSF53300; vWA-like; 1.
DR PROSITE; PS00243; INTEGRIN_BETA; 1.
PE 3: Inferred from homology;
KW Cell adhesion {ECO:0000256|ARBA:ARBA00022889,
KW ECO:0000256|RuleBase:RU000633};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Disulfide bond {ECO:0000256|PIRSR:PIRSR002512-1};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Integrin {ECO:0000256|ARBA:ARBA00023037, ECO:0000256|RuleBase:RU000633};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000007303};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU000633};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 716..738
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 26..74
FT /note="PSI"
FT /evidence="ECO:0000259|SMART:SM00423"
FT DOMAIN 34..459
FT /note="Integrin beta subunit VWA"
FT /evidence="ECO:0000259|SMART:SM00187"
FT DOMAIN 631..715
FT /note="Integrin beta subunit tail"
FT /evidence="ECO:0000259|SMART:SM01242"
FT DOMAIN 739..785
FT /note="Integrin beta subunit cytoplasmic"
FT /evidence="ECO:0000259|SMART:SM01241"
FT DISULFID 27..459
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 35..45
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 38..73
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 48..62
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 201..208
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 256..297
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 398..410
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 430..678
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 457..461
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 472..483
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 481..518
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 485..494
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 524..529
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 526..559
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 531..544
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 546..551
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 565..570
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 567..598
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 572..581
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 583..590
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 604..609
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 606..654
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 611..621
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 624..627
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 631..640
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 637..710
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 658..686
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
SQ SEQUENCE 785 AA; 85890 MW; F7643E945E38D5FA CRC64;
LCRRPLGVLP LELLKGLGMT GSASNICTSR GVTTCQQCLA VHPSCAWCSQ EDFGKGSSIS
RCDLKENLLK EGCSQAAVEF PSSTLTVDQD APLSDKASGV ADDVIQVKPQ KIRVTLRQGD
AKRFTVYVKQ VEDYPVDLYY LMDLSYSMKD DLSNLRTLGN KLADTMGRTT SKLRMGFGAF
VDKTVSPYMY TYPPLAVENP CYKDQVKCQA QFGFKHVLSL TEQVGRFTEE VEKQQVSKNR
DAPEGGFDAV MQAVVCKENV GWRADASHLL VFTTDAKTHI ALDGRVAGIV QPNDGKCHLD
YSNNYNQSTI LDYPSLALMT EKMSENNINL IFAVTNYVVP LYKEYSKLIP GTTVGILSDD
SGNVIELIKE AYEKIRSKVQ LELLGVPDEL NLSFNATCQS GEVVPGLKSC SGLKIGDTVS
FSIEAQLRRC PKDKSRTFTI KPLGFKDSLE ITVDFACSCN CEAGAQANSS LCSHGNGTYE
CGCQCHSGRL GPRCECSVED YSPSDDANCI DKADGPVCSG RGDCLCGQCS CHGNDFGQVW
GKYCQCDDFN CLRFRGELCS NHGKCSCGSC VCDAGWKGEN CNCSTRTDTC MSSIGLLCSG
RGNCECGVCQ CTQPGAYGAT CEKCPTCPDS CTIKKHCVEC QHFKRGQYIE DNSCSRICKD
EIKVVDEIGV RDNNAVNCSY KDEDDCLVHF QYYEDESGKS ILSVVKMLEC PEGPNILVVL
LAVAGAILLL GLVGLLIWKL VITIHDRKEF AKFEEERARA KWDTGNNPLY KGATSTFTNI
AYKGN
//
