ID H3C0X8_TETNG Unreviewed; 733 AA.
AC H3C0X8;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 1.
DT 27-MAR-2024, entry version 58.
DE SubName: Full=von Willebrand factor A domain containing 2 {ECO:0000313|Ensembl:ENSTNIP00000001894.1};
GN Name=VWA2 {ECO:0000313|Ensembl:ENSTNIP00000001894.1};
OS Tetraodon nigroviridis (Spotted green pufferfish) (Chelonodon
OS nigroviridis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Tetraodon.
OX NCBI_TaxID=99883 {ECO:0000313|Ensembl:ENSTNIP00000001894.1, ECO:0000313|Proteomes:UP000007303};
RN [1] {ECO:0000313|Proteomes:UP000007303}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15496914; DOI=10.1038/nature03025;
RA Jaillon O., Aury J.-M., Brunet F., Petit J.-L., Stange-Thomann N.,
RA Mauceli E., Bouneau L., Fischer C., Ozouf-Costaz C., Bernot A., Nicaud S.,
RA Jaffe D., Fisher S., Lutfalla G., Dossat C., Segurens B., Dasilva C.,
RA Salanoubat M., Levy M., Boudet N., Castellano S., Anthouard V., Jubin C.,
RA Castelli V., Katinka M., Vacherie B., Biemont C., Skalli Z., Cattolico L.,
RA Poulain J., De Berardinis V., Cruaud C., Duprat S., Brottier P.,
RA Coutanceau J.-P., Gouzy J., Parra G., Lardier G., Chapple C.,
RA McKernan K.J., McEwan P., Bosak S., Kellis M., Volff J.-N., Guigo R.,
RA Zody M.C., Mesirov J., Lindblad-Toh K., Birren B., Nusbaum C., Kahn D.,
RA Robinson-Rechavi M., Laudet V., Schachter V., Quetier F., Saurin W.,
RA Scarpelli C., Wincker P., Lander E.S., Weissenbach J., Roest Crollius H.;
RT "Genome duplication in the teleost fish Tetraodon nigroviridis reveals the
RT early vertebrate proto-karyotype.";
RL Nature 431:946-957(2004).
RN [2] {ECO:0000313|Ensembl:ENSTNIP00000001894.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR AlphaFoldDB; H3C0X8; -.
DR Ensembl; ENSTNIT00000001914.1; ENSTNIP00000001894.1; ENSTNIG00000018899.1.
DR GeneTree; ENSGT00940000159040; -.
DR HOGENOM; CLU_008905_7_3_1; -.
DR Proteomes; UP000007303; Unassembled WGS sequence.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR CDD; cd00053; EGF; 1.
DR CDD; cd00054; EGF_CA; 1.
DR CDD; cd01450; vWFA_subfamily_ECM; 1.
DR Gene3D; 2.10.25.10; Laminin; 2.
DR Gene3D; 3.40.50.410; von Willebrand factor, type A domain; 3.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR002035; VWF_A.
DR InterPro; IPR036465; vWFA_dom_sf.
DR PANTHER; PTHR24020; COLLAGEN ALPHA; 1.
DR Pfam; PF00008; EGF; 1.
DR Pfam; PF00092; VWA; 3.
DR PRINTS; PR00453; VWFADOMAIN.
DR SMART; SM00181; EGF; 2.
DR SMART; SM00179; EGF_CA; 2.
DR SMART; SM00327; VWA; 3.
DR SUPFAM; SSF57184; Growth factor receptor domain; 1.
DR SUPFAM; SSF53300; vWA-like; 3.
DR PROSITE; PS01186; EGF_2; 1.
DR PROSITE; PS50026; EGF_3; 2.
DR PROSITE; PS50234; VWFA; 3.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; Reference proteome {ECO:0000313|Proteomes:UP000007303}.
FT DOMAIN 28..200
FT /note="VWFA"
FT /evidence="ECO:0000259|PROSITE:PS50234"
FT DOMAIN 273..310
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 320..496
FT /note="VWFA"
FT /evidence="ECO:0000259|PROSITE:PS50234"
FT DOMAIN 510..684
FT /note="VWFA"
FT /evidence="ECO:0000259|PROSITE:PS50234"
FT DOMAIN 691..726
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
SQ SEQUENCE 733 AA; 79742 MW; 66137250470889B2 CRC64;
LQEIQTSHEN IKKITAAGQL MQCSAAMDIL FLMDGSYSVG KGSFERSKHY ALKLCQALDI
RPDKVRVGLI QFGSAPRLEF ALDLHATKQE LMRHMKKISY RGGSTQTGLA LKYVLRKGLP
GGRNSSDAAQ IVIVLSDGKS QGNVMQAAAQ LKETGVVLFA VGLRYPRWEE LHALASEPVE
NHVFFAEHFY DAVNGLYTTL ATFSVCSATP QGCHMRSFPC ERKTLETVKE LLGNFMCWKG
TKGYSPYTSL CPHYRYNKVY KRHQTVCHRT ICPDPCDSQP CLNSGTCVSE GSEGYRCVCP
PGYGGDPHCA PALSLDCSVD LLFLVEGSSA MTLEGFLRLK SFLKRFLQTV IGSDSPSKVG
LAVFGSDTRV EAQVGQFRGD PKSLLKAVEA LQQYGGEART GQALRYVTRH GFVSTPVFAD
VSDDLPRVVV LMTSTPAVDE VVEASRYARD REIFLIGMGP HYLKSQLNTI TGNPQRTVTY
SSSEFGIKIP ELKAKICSVD TQGCLGQALD LVFALDASDG VGRDNFLTLC DFVRSLSVQF
DINRDVAQLA LVAYSRRATT VFNLDTHDSG SAVLTAIGEA SYMGGVASTG TALLHVHSDV
LTVDKGARLG VNKAVVVVTD GSGGTDAVVP AQKLRDNGVS VFVVGIGDMQ REKLLQIAGS
EEHLILVPSY EDLKYFEDVL VQMLCSEAKM PVNLCKPNPC MHDGVCTLSG ASFRCQCRGY
EGPQCETNFS FSP
//
