GenomeNet

Database: UniProt
Entry: H3C4X6_TETNG
LinkDB: H3C4X6_TETNG
Original site: H3C4X6_TETNG 
ID   H3C4X6_TETNG            Unreviewed;      4950 AA.
AC   H3C4X6;
DT   18-APR-2012, integrated into UniProtKB/TrEMBL.
DT   18-APR-2012, sequence version 1.
DT   28-MAR-2018, entry version 41.
DE   SubName: Full=Ryanodine receptor 2b (cardiac) {ECO:0000313|Ensembl:ENSTNIP00000003295};
OS   Tetraodon nigroviridis (Spotted green pufferfish) (Chelonodon
OS   nigroviridis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae;
OC   Tetraodon.
OX   NCBI_TaxID=99883 {ECO:0000313|Ensembl:ENSTNIP00000003295, ECO:0000313|Proteomes:UP000007303};
RN   [1] {ECO:0000313|Ensembl:ENSTNIP00000003295}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15496914; DOI=10.1038/nature03025;
RA   Jaillon O., Aury J.-M., Brunet F., Petit J.-L., Stange-Thomann N.,
RA   Mauceli E., Bouneau L., Fischer C., Ozouf-Costaz C., Bernot A.,
RA   Nicaud S., Jaffe D., Fisher S., Lutfalla G., Dossat C., Segurens B.,
RA   Dasilva C., Salanoubat M., Levy M., Boudet N., Castellano S.,
RA   Anthouard V., Jubin C., Castelli V., Katinka M., Vacherie B.,
RA   Biemont C., Skalli Z., Cattolico L., Poulain J., De Berardinis V.,
RA   Cruaud C., Duprat S., Brottier P., Coutanceau J.-P., Gouzy J.,
RA   Parra G., Lardier G., Chapple C., McKernan K.J., McEwan P., Bosak S.,
RA   Kellis M., Volff J.-N., Guigo R., Zody M.C., Mesirov J.,
RA   Lindblad-Toh K., Birren B., Nusbaum C., Kahn D., Robinson-Rechavi M.,
RA   Laudet V., Schachter V., Quetier F., Saurin W., Scarpelli C.,
RA   Wincker P., Lander E.S., Weissenbach J., Roest Crollius H.;
RT   "Genome duplication in the teleost fish Tetraodon nigroviridis reveals
RT   the early vertebrate proto-karyotype.";
RL   Nature 431:946-957(2004).
RN   [2] {ECO:0000313|Ensembl:ENSTNIP00000003295}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (FEB-2012) to UniProtKB.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00448}.
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DR   Ensembl; ENSTNIT00000002362; ENSTNIP00000003295; ENSTNIG00000017023.
DR   eggNOG; KOG2243; Eukaryota.
DR   eggNOG; ENOG410YCNW; LUCA.
DR   GeneTree; ENSGT00760000119152; -.
DR   Proteomes; UP000007303; Unassembled WGS sequence.
DR   GO; GO:0005623; C:cell; IEA:GOC.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0005219; F:ryanodine-sensitive calcium-release channel activity; IEA:InterPro.
DR   CDD; cd12877; SPRY1_RyR; 1.
DR   CDD; cd12879; SPRY3_RyR; 1.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR001870; B30.2/SPRY.
DR   InterPro; IPR013320; ConA-like_dom_sf.
DR   InterPro; IPR011992; EF-hand-dom_pair.
DR   InterPro; IPR002048; EF_hand_dom.
DR   InterPro; IPR014821; Ins145_P3_rcpt.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR036300; MIR_dom_sf.
DR   InterPro; IPR016093; MIR_motif.
DR   InterPro; IPR013662; RIH_assoc-dom.
DR   InterPro; IPR000699; RIH_dom.
DR   InterPro; IPR013333; Ryan_recept.
DR   InterPro; IPR003032; Ryanodine_rcpt.
DR   InterPro; IPR015925; Ryanodine_recept-rel.
DR   InterPro; IPR009460; Ryanrecept_TM4-6.
DR   InterPro; IPR035910; RyR/IP3R_RIH_dom_sf.
DR   InterPro; IPR035761; SPRY1_RyR.
DR   InterPro; IPR035762; SPRY3_RyR.
DR   InterPro; IPR003877; SPRY_dom.
DR   PANTHER; PTHR13715; PTHR13715; 1.
DR   Pfam; PF08709; Ins145_P3_rec; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF02815; MIR; 1.
DR   Pfam; PF08454; RIH_assoc; 1.
DR   Pfam; PF06459; RR_TM4-6; 1.
DR   Pfam; PF01365; RYDR_ITPR; 2.
DR   Pfam; PF02026; RyR; 4.
DR   Pfam; PF00622; SPRY; 3.
DR   PRINTS; PR00795; RYANODINER.
DR   SMART; SM00472; MIR; 4.
DR   SMART; SM00449; SPRY; 3.
DR   SUPFAM; SSF100909; SSF100909; 1.
DR   SUPFAM; SSF47473; SSF47473; 1.
DR   SUPFAM; SSF48371; SSF48371; 7.
DR   SUPFAM; SSF49899; SSF49899; 3.
DR   SUPFAM; SSF82109; SSF82109; 1.
DR   PROSITE; PS50188; B302_SPRY; 3.
DR   PROSITE; PS50222; EF_HAND_2; 1.
DR   PROSITE; PS50919; MIR; 5.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000007303};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000007303};
KW   Repeat {ECO:0000256|SAAS:SAAS00903904};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4259   4282       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4488   4509       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4556   4575       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4702   4727       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4750   4772       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4793   4811       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4831   4854       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       98    153       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      160    214       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      222    277       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      283    338       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      348    405       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      602    806       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     1023   1220       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     1345   1550       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     4022   4057       EF-hand. {ECO:0000259|PROSITE:PS50222}.
FT   COILED     3322   3342       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   4950 AA;  555130 MW;  DC8A90E6494B0FC5 CRC64;
     MSDFGEGDEE FQFLRTGDEV VLQSIFTLRG EHVKICLAAE GFGTRLCRLE PIFNCKNVPP
     DVSVCGFVLA HCLSVRALQE MLTHTEHLAA ELAAGGGHRT LLYGQAVLFL HSYSSMYLSC
     LSSSQSATDK LAFDVGLQED KEGETCWWIV HPSSRQRSEG EKVRVGDDLI LVSMSSERYL
     HLSVGSGSDS SSSLSDSLSV SASFQPTLWS VAPIYSGGGV AQGYLKGGDT FRLHHSHSDA
     CLTIASADQG EEPQKVMHYE SGAVSSHARS LWRLEILHVV WSGSHTCWGQ PFRLCHMTTG
     RYMGLTEERG LHLVERDKAD VRMSSFCFRS SKEKLDPGTR TNADGMGSPE IKYGDSVCYV
     QHVDSGLWLT YRPVDAKSSR LRSTQRKAIL HSEGHMDDGL RLSRCQREES HTARLIRSAS
     FLFTNFIRKQ DSCSQHGNQV SVCSPGEMMK RSLQDLISYF YPTPETVEHE AKCHNMVVLK
     NRQNMFQEEG VIDLVLVCID HLHQHIGTSQ CAEAAQEDSE EEWESCLDGF YKLLAALLRG
     NRANCARFSA SIDWLISKLD WLEAATGVLE VLQCVLLESP EALNVVKENH IHSVISFLDK
     HGLNHKVLEV LCALCVCHGV AVRYNQNLIC DKLLPERDLL LQTRLVNRVT SMRPNIFLAF
     SEDSAQHRRW YYEVVVDHLD SFLTSEPTHL RVGWACTEGY RPRLSGGEGW GGNGVGDDLC
     SYGFDGLHLW AGGVGRSVSS PFSHSLKDGD VVSCCLDLSA PCISFRVNGL PVQGMLENFV
     AEGLLYPVVS FSAGVRIRFL FGGQHGEFRY LPPPGFTACS DALLPKVKLK VEPCQKYILN
     REEGKHDLIG PWIPTAPVVF IPAPVDISKV SLPPQLEDIQ EKLAENIHEL WAMDKIDLGW
     TYGPVRDEAK KNDPSLAEFS KLSEHERNQN LHVAQDTLRT LLAFGFCIGF NEGHSNDRVR
     NKRLAAKYEQ PGGYRPAPVD LSQVLLSSEH QEVVNLLAEN DHNVWARERI AQGWTYGTQQ
     DVKAKRSPYL VPYSFLDEKT RRLSRDSVRE VVGTLLAFGY SLDPHSLKQA TLANQCLFSA
     EKCRVFRPDK SHAVSRGKWY FEFEAVTAGK MRVGWARPSC SPSRELGSDD RAFVFDGFEA
     QWYHQGAEPL GRSWQRGDVV GCLVDMDEST MMITLNGELL FDARGSELAA KDFDISDGLL
     PVASLGVNQV GRLNLGRCAA SLQYFTVCGQ QEGYQPFAVN MARDPALWIS WQQPQFSSIR
     PDDHIQVGVT RASGSVGSLS SLRVSQRLFA HYNGSSQISF FRLSMHIECA SVLISPAGGV
     LPVASSSLSP GRREQEEVDP DFEVLRKSAL TFAGSRDELN HKDHNQEKTT RMKHRFLLKR
     NKPGLVSSNS SARLLEDVVF DKENCDHLIQ SSRYYYSARV LPGQEPFNVW VGWVTSNFHS
     HDATFDPDGV HTVTVTLGDD SGKVQESIKR RVCYMVCAGE ATGLAQSRRS SGLEIGCLID
     TATGLLTFTS NGVEMSTFFQ VEACTKLFPA VFVRPTTTCM FQFEFGCIKN AMPLSAGLLR
     SQRCNVTPHC PPRIQVQQLK PGSWTRLPSQ AVKVVVDQPD AYGGWTIQCS EALQVMNLQI
     PDENRCVDIL ELSELDDLLT FHLHTLRLYC SLCSLGNTRV SHAICSYLDT SQFLHAIQNP
     HLPGLLRSVF YQLLIQVHLS SHTTACLMMN HEYIIPMAAK AGDTTLYPSS FTGHNGGNGI
     TNSSHCTSLK PQMHFSSPSF VSNYALEGNY TAERNHGDSP EFPLDLLKNL TIQMLTEAVT
     ALCQEVRDPV GGTIELLLVP LIKLAYSLLV MGVLEDEDLG KVLRLLDSEV SFTNSQSSMD
     EEKEDEKDDE KEHSLHHHQK DSHPKIGLLQ IKLPEAVKLE LCHLLSYLCD CQMRQRVEAV
     AAFSDTFVCQ LQENQRFRYN EVMQALNMSA ALTARKTKEF RSPPREQINM LLSFRDDEVS
     CPCPVQIQEL LHNFHHLFKT HCGIESESDG EDEEAAESVR TQILSQVAKV IGIKKKPLEV
     DASKPVASKT LKHLVSKTLV HWSQEKMQDP ELVRAVFSLL HCQYQGLGGQ MAGPLSRTYT
     ISHTSVDDTM ALLSSLSQIR SLLCVRMGKE EEKLMIRKLG DIINNKVFYQ HPDLMRTLGM
     HETVMEVMVN VLGEGESKEI AFPKMVASCC RFLCYFCRIS QHNQGALFDH LSYLLENASV
     GLASPSMRGA TPLDVAAASV MDNNELALAL TESNLQKVIH YLASCGLKSC PMLVAKGYPD
     IGWNPVEGER YLDFLRFAVF CNGESVEENA YMVLRLLIRR PECFGPALQG DGGNGLLAAV
     REAIRISDDP SMDGPSGPHQ STRSIDVIQD NDDDLIHMGH AMVTFYSALI DLLGRCAPEM
     HLIEGGKGEA LRVRAILRSL VPVHDLEGVI SSSFCLPSVT KDGGVVEPDL SAVFCPDHKA
     AMVLFLDRVY GIQNQSFFLH LIEVGFLPDL QAAVSLDTVD LASTDMALAL NRYLCASVLP
     LLSKCSALFC DLEDHVLLVD SLIQAIYSLS HALSLTKAQR DTIEDCLLAL CSKLQPSLMQ
     PLLRRLVFDV PHLPEHNKLA LKLLTSHYEQ RWKYYSMVGE PGDHSLASEE ELHLSRKLFW
     SVFKDLNKKP YEPQLFRLCV QCLAAVAKAL PPDHTDAGCT SAMEGKASAD EQFDPQPIDT
     SNVSVPERLE FIVNKYAEHT HEKWSLDKFA NGWVHGEQLC ESSKVHPLLK PYRTLAEKEK
     EAYRCAIKET IKTMLAFGWS IERTKEADAH SVHTCARRVS QSGQQLSFEG TSTFSPKPTD
     VSTITLSWDQ CAMAEQLAEN YHSTWAKRKK LELQGRGGGG HSMVVPYDAL TAREKTKFRE
     RAQDVLKFLH LNGYTVWRDR RTVEMDFPAV ANCFGSTLLM QFLSHTENTQ EHMLEMEVMQ
     ARGQTSKGER TQLRQPVQVF HKVILPLLEE YVRTHCLYFL SSMSLSGKRG HASNKEKEMI
     ASLFCKLAAL IRHRMSLFGN EASAVSNCLC TLAQALDART LMNSASESVR SSLDSFFESS
     AADLEMTVEN LCVSVARLSQ SRSQHARGVA RVLSYTSVVL LPTLTSLFQH LGLQNYGGDL
     LVGTIQVSCY KILNSLYSLG TTSSIYMEGQ RPAAGACLAA LAATFPVCFL EPDLNQNNPY
     SIYNTASALE KEELGLPDHA GDMCPLLPSL EQALGDVKQL AAAGAGARQS QYIHVTEVVL
     PMLCSYMSLW WSWGPEGQPN SPLCTTVTPQ HASDLLGHVL RIIHNHVGTS QADWMKRMAV
     HCLSITCHAH PELLKTHFLP LMEKLKKRAE GVLLEEERMK ADAGDSSEAE LEIQQKFMVL
     VADLYAFYPL LIPFVDSNRA RWLKESTPEA EQLFIMVAEV FTFWAKSHNF KWEEQNYVVQ
     NEINSLLFLV KSNKLSKVSK VDIISVSNLN HEKRKVKKKG DRYSTHTSLV VASLKRLLPV
     GLRNCLLSDR SLITLAKNGF TQKDTEDEIR QHIFSAFTLL QTQDHSFLND EVNDAERGGQ
     RGKTADVQKA VDRVLNMGRV LCYLDQVEHP QRNRKTARHK ILSKQRKRAV VACLRMAPLY
     NLPRHRAVNL FLQGYNKTWI STEDHSFEEK LVEDLALSGG VAENDTVDGI KAIDPLLQLI
     TLFSQTALME SSKLENGRLY QSYAAIMAKS CQRDDDGDGK EQELESFEEK ELEKQKLLFR
     QARLHRRGAS EMVLQIISAS RGLMGSVIAP TLKLGIALLS GGNAAVQQKM LVYLRERRDV
     GFFQSMAGLM LSCSVLDLSA FERQNKAEGL GMAMDESSGP LFSPADKVMP DKDVTCDLFR
     FLQLLCEGHN SEFQNYLRTQ AGNNTTVNIV ISTVDYLLRL QESVSDFFWY YSGKAAIDVH
     GQHNFSKAIE VSKQVFNTLT EYIQGPCAGN QESLAHSRLW DAVIGFLHVF AHMQMKLPQD
     SRQIDLLKEL LDLQKDMVVF LLSMLEGNIV NGTIGKQMVD MLVESSGNVQ MILRFFDMFL
     KLKDFTSSDA FQAYDPDFKG CVSRKDFQKA MEGCKRFSQA ETHFLMSCMG PDDREKVDYE
     AFVDGFHEPA QDIGFSIAVL LTNLSEHMPN DSRLRTFLEV AESVLTYFQP FLGRIEILGS
     GKRIERVYFG ISASSRTQWE KPQVKESKRQ FVFDVVNESG DKEKMEMFVN FCEDTIFEMQ
     LAAQLSGSGV EERHVEASPE EKGDTNGLDN KGIGVMCQWL VLTSVLSVKA LMKMSVKDVL
     VSAVVFLKFV LMAQFRCVLI VVRSIWYVLH RAFLSGELIE GAKRARISEM LGGILEPTLD
     EVMGGPRGTR LRKGSSSLTL QKELSGSRLA QTMASTRDMH VLSDIFGLTV KKEGSGYRLI
     SKDLTDSLTD LFTPACRGAT CLDHFCAILT LFSEPQTHIH QEEKTEEKGA DGKQNKSDQN
     SEAILKDPKW RAQRLNPKSK EAENQPSALW EMVSTHNKSM LNYFARNFYN LRVLALFVAF
     AINFILLFYK VASSPAAQVE EKEMPSAYSA GDDAEEGTVC FVLEERSGYM EPSLRFLAVA
     HTIISFFCIF GYYCLKVPLV IFKREKEVAR KLEFDGLYVT KQPPEEDIKG QWDRLVVNTP
     SFPSNYWDKF VKRKVMDKYG EFYGCEKISD LLGLDQAALD CSSERKGRKR LRRSTVWSHL
     FSSIDVKYQV WKTGVVFTDN SFLYLAWYMA MSVLGHYNNF FFAAHLLDVA MGFKTLRTIL
     SSVTHNGKQL VLTVGLLAVV VYLYTVLAFN FFRKFYNKSE DKDARDMKCN DMLTCYMFHM
     YVGVRAGGGI GDEIEDPAGD EFEVERIVFD ITFFFFVIVI LLAIIQGLII DAFGELRDQQ
     EQVKEDMETK CFICGIGSEY FDKVPHGFET HTLQEHNLAN YLFFLMYLIN KDETEYTGQE
     SYVWKMYQER SWEFFPVGDC FRKQYEGQLG
//
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