ID H3C4Z4_TETNG Unreviewed; 2567 AA.
AC H3C4Z4;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 1.
DT 27-MAR-2024, entry version 69.
DE SubName: Full=Filamin A, alpha (actin binding protein 280) {ECO:0000313|Ensembl:ENSTNIP00000003313.1};
OS Tetraodon nigroviridis (Spotted green pufferfish) (Chelonodon
OS nigroviridis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Tetraodon.
OX NCBI_TaxID=99883 {ECO:0000313|Ensembl:ENSTNIP00000003313.1, ECO:0000313|Proteomes:UP000007303};
RN [1] {ECO:0000313|Proteomes:UP000007303}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15496914; DOI=10.1038/nature03025;
RA Jaillon O., Aury J.-M., Brunet F., Petit J.-L., Stange-Thomann N.,
RA Mauceli E., Bouneau L., Fischer C., Ozouf-Costaz C., Bernot A., Nicaud S.,
RA Jaffe D., Fisher S., Lutfalla G., Dossat C., Segurens B., Dasilva C.,
RA Salanoubat M., Levy M., Boudet N., Castellano S., Anthouard V., Jubin C.,
RA Castelli V., Katinka M., Vacherie B., Biemont C., Skalli Z., Cattolico L.,
RA Poulain J., De Berardinis V., Cruaud C., Duprat S., Brottier P.,
RA Coutanceau J.-P., Gouzy J., Parra G., Lardier G., Chapple C.,
RA McKernan K.J., McEwan P., Bosak S., Kellis M., Volff J.-N., Guigo R.,
RA Zody M.C., Mesirov J., Lindblad-Toh K., Birren B., Nusbaum C., Kahn D.,
RA Robinson-Rechavi M., Laudet V., Schachter V., Quetier F., Saurin W.,
RA Scarpelli C., Wincker P., Lander E.S., Weissenbach J., Roest Crollius H.;
RT "Genome duplication in the teleost fish Tetraodon nigroviridis reveals the
RT early vertebrate proto-karyotype.";
RL Nature 431:946-957(2004).
RN [2] {ECO:0000313|Ensembl:ENSTNIP00000003313.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the filamin family.
CC {ECO:0000256|ARBA:ARBA00009238}.
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DR STRING; 99883.ENSTNIP00000003313; -.
DR Ensembl; ENSTNIT00000001207.1; ENSTNIP00000003313.1; ENSTNIG00000004951.1.
DR GeneTree; ENSGT00940000153588; -.
DR InParanoid; H3C4Z4; -.
DR OMA; KWADEHI; -.
DR TreeFam; TF313685; -.
DR Proteomes; UP000007303; Unassembled WGS sequence.
DR GO; GO:0043232; C:intracellular non-membrane-bounded organelle; IEA:UniProt.
DR GO; GO:0051015; F:actin filament binding; IEA:InterPro.
DR GO; GO:0030036; P:actin cytoskeleton organization; IEA:InterPro.
DR CDD; cd21308; CH_FLNA_rpt1; 1.
DR Gene3D; 1.10.418.10; Calponin-like domain; 2.
DR Gene3D; 2.60.40.10; Immunoglobulins; 23.
DR InterPro; IPR001589; Actinin_actin-bd_CS.
DR InterPro; IPR001715; CH_dom.
DR InterPro; IPR036872; CH_dom_sf.
DR InterPro; IPR044801; Filamin.
DR InterPro; IPR017868; Filamin/ABP280_repeat-like.
DR InterPro; IPR001298; Filamin/ABP280_rpt.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR014756; Ig_E-set.
DR PANTHER; PTHR38537:SF5; FILAMIN-A; 1.
DR PANTHER; PTHR38537; JITTERBUG, ISOFORM N; 1.
DR Pfam; PF00307; CH; 2.
DR Pfam; PF00630; Filamin; 23.
DR SMART; SM00033; CH; 2.
DR SMART; SM00557; IG_FLMN; 23.
DR SUPFAM; SSF47576; Calponin-homology domain, CH-domain; 1.
DR SUPFAM; SSF81296; E set domains; 23.
DR PROSITE; PS00019; ACTININ_1; 1.
DR PROSITE; PS00020; ACTININ_2; 1.
DR PROSITE; PS50021; CH; 2.
DR PROSITE; PS50194; FILAMIN_REPEAT; 23.
PE 3: Inferred from homology;
KW Actin-binding {ECO:0000256|ARBA:ARBA00023203};
KW Reference proteome {ECO:0000313|Proteomes:UP000007303};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 42..147
FT /note="Calponin-homology (CH)"
FT /evidence="ECO:0000259|PROSITE:PS50021"
FT DOMAIN 165..268
FT /note="Calponin-homology (CH)"
FT /evidence="ECO:0000259|PROSITE:PS50021"
FT REPEAT 275..373
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 375..473
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 474..570
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 571..663
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 668..764
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 765..867
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 868..966
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 967..1062
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 1083..1177
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 1178..1277
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 1278..1370
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 1371..1466
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 1467..1563
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 1576..1667
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 1721..1779
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 1779..1871
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 1869..1958
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 1961..2054
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 2052..2150
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 2153..2245
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 2247..2340
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 2344..2436
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 2470..2567
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REGION 1..36
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1003..1025
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..18
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2567 AA; 273665 MW; 9B219E4FFDBC6AB0 CRC64;
MSGSHPRLHQ SAAPAPNTLS SDKDAEMPAT EKDLAEDAPW KKIQQNTFTR WCNEHLKCVN
KRIANLQTDL SDGLRLIGLL EVLSQKKFRK YNQRPTFRQM QLENVSVALE FLDRENIKLV
SIDSKAIVDG NLKLILGLIW TLILHYSISM PMWDEEEEAD DGKQKTPKQR LLGWIQNKLP
ELPITNFNRD WQTGQALGAL VDSCAPGLCP DWDQWDQSKP VDNAREAMQQ ADDWLGIPQV
ITPEEIVDPN VDEHSVMTYL SQFPKAKLKP GAPLRPKLNP KKARAYGPGV EPVGNVVMKK
TVFTVETISA GMGEVLVYVE DPAGHREEAK VTANNDKNRT YSVFYTPRVT GMHKVTVLFA
GQHISKSPFE VEIGMAQGDS SKATAQGPGL EPSGNIANKT TYFDVYTAGA GVGEVEVIIM
DPSGKNSTVK CNIEDKGNNS YRCTYKPTQE GQHIISVTFA GGQISRSPFT VSVGEACNPN
LCRAKGRGLQ PKGLRVKETA DFKVYTKGAG TGELKVSIKG PKGLEEPCKR KDLGDGVYGF
EYYPTSPGTY SITITWGGQH IPRSPIEVKI SPEAGQQKVR AWGPGLEGGV VGKSADFVVE
AVGDDVGTLG FSVEGPSQAK IECDDKGDGS CDVRYWPTEP GEYAVHVLCN NEDIQHSPFM
AEIVTPPSKD FYPDKVKAFG PGLQSSGLAV GKPTEFTVDA KHGGKAPLKI VAQDGEGVPV
DVQVKDNGNG TYSCSYTPRK PVKHTAMISW GGVNIPDSPF RMNIGAGCHP NKVKVSGPGV
AKSGLKAFEP TYFTVDCSEA GQGDISIGIK CAPGVVGPAE ADIDFDIIRN DNDTFTVKYT
PPGAGSYTIM VLFADQAIPM TPIRIKVDPA HDASKVKAEG PGLSRTGVEL NKPTHFTVST
KGAGKANLDC TFSGPTKVEA AKDVEVINNH DNTHTVKYTP VQQGPLGIGV TYGGDHVPKS
PFTVTVAPTL DLSKISVAGL GEKMTVGKDQ DIIIKTKGAG GQGKVGAKVT APSGKPVASK
VEPGLSPETS QVKFIPREAG PYQVELTYDG VPIPGSPFSP TAYSASDPSK VGRPRRQKDL
HVLNNNTSPQ VRCSGPGLER ARVGEKGEFF VDCTNAGPAD LTIEIISDSG TEAEVHIQDN
GDGTYTITYI PLYPGSYTLT IRYGGQDVPN FPARLNVEPA VDASGVRVFG PGVESKGVFR
EATTDFTVDA RALAPNGGDH IKTLISNPSG SCTDALISDL GDGTYSVAYT PYEEGPHSVE
VCYDGMPVPK SPFHVAVTEG CNPGRVRVHG PGLKGGTTNK PNKFTIETRG AGTGGLGLAM
EGPSEAKMSC IDNKDGSCSV EYVPYEPGTY NLNITYGGQP ITGSPFSVPV SDTVDSTKVK
CQGPGLGNNV RANIPQAFTV DASKAGVAPL QVRVQGPKGV VEPVEVVDNG DQTHTVNYVP
TREGPYSINV LYDDEEIPRS PYKVKVLPTH DASKVRASGP GLNTTGVPAS LPVEFTIDAK
DAGEGLLAVQ ITDPEGKPKK ANIRDNHDGT YLVSYVPDMT GRYTILIKYG GDEIPYSPYR
IRALPTGDAS KCTVTVSIGG HGLGAGIGPT IQIGEQTVIT VDAKAAGKGK VTCSVCTPEG
AELDVDVVEN EDGTFDIFYT APQPGEYVIC VRFGGEHIPN SPFQVTALEG APSQQLLQQS
QVPQYYAPQS WATDRPMGMN GLDVAGLRPF DLVIPFTIQK GEITGEVRMP SGKVAKPDIT
DNKDGTVTVK YAPTEAGLHE MDIKYEGIHI PGSPLQFFVD YINSGNVSAY GPGLIHGTVN
KPAVFTVDTK DAGEGGLSLA IEGPSKADIS CVDNQDGTCT VSYLPVLPGD YSILVKYNDK
HIPGSPFSAR ITGDDSMRMS HLKVGSAADI PLDIGELDLT QLTASLTTPS GREEPCLLKM
LRNGHVGISF VPKEIGEHLV NIKKNGRHIP NSPISVMIRE SEIGDASRVR VSGQGLSEAR
TFEPAEFIID TRDAGYGGLS LSIEGPSKVD INTEDQEDGT CKVTYCPTEP GNYIINIKFA
DQHVPAGSAF TVKVTGEGRM KESITRKRRA PSVANVGSQC DLSLKIPEIN MAEMTAQVTS
PSGQRHKADI MEGENNTYCI RFVPTETGVH TVSVKYQGSH VPGSPFQFTV GPLGEGGAHK
VRAGGPGLER AEAGVPAEFS IWTREAGAGG LSIAVEGPSK AEIAFEDRKD GSSGVSYIVQ
EPGDYEVSIR FNDEHIPDSP FIVPVASPSD DARRLTVASL QESGLKVNQP ASFAVSLNGA
KGMIDAKVHS PSGALEECCI TEIDQDKYAV RFIPRENGLY LIDVKFNGSH IPGSPFKIRV
GETGQAGDPG MVSAYGAGLE GGSTGSACEF LVNTSKAGPG ALAVTIDGPS KVKMDCVECP
EGYRVTYTPM APGSYLISIK YGGPYHIVGS PFKARISGSK LVSSHSAHET SSVTVDPVTR
AISCSPAGAS SQSDASKVLA KGLGLSKAYL GQKNSFSVDC SKAVFTGRNM LLVGVDGPKV
PCEEILVKHL GNRMYNVSYQ LKEKGEYILV VKWGDEHIPG SPYHITV
//
