ID H3C510_TETNG Unreviewed; 1644 AA.
AC H3C510;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 1.
DT 27-MAR-2024, entry version 49.
DE SubName: Full=Otoferlin b {ECO:0000313|Ensembl:ENSTNIP00000003329.1};
GN Name=OTOF {ECO:0000313|Ensembl:ENSTNIP00000003329.1};
OS Tetraodon nigroviridis (Spotted green pufferfish) (Chelonodon
OS nigroviridis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Tetraodon.
OX NCBI_TaxID=99883 {ECO:0000313|Ensembl:ENSTNIP00000003329.1, ECO:0000313|Proteomes:UP000007303};
RN [1] {ECO:0000313|Proteomes:UP000007303}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15496914; DOI=10.1038/nature03025;
RA Jaillon O., Aury J.-M., Brunet F., Petit J.-L., Stange-Thomann N.,
RA Mauceli E., Bouneau L., Fischer C., Ozouf-Costaz C., Bernot A., Nicaud S.,
RA Jaffe D., Fisher S., Lutfalla G., Dossat C., Segurens B., Dasilva C.,
RA Salanoubat M., Levy M., Boudet N., Castellano S., Anthouard V., Jubin C.,
RA Castelli V., Katinka M., Vacherie B., Biemont C., Skalli Z., Cattolico L.,
RA Poulain J., De Berardinis V., Cruaud C., Duprat S., Brottier P.,
RA Coutanceau J.-P., Gouzy J., Parra G., Lardier G., Chapple C.,
RA McKernan K.J., McEwan P., Bosak S., Kellis M., Volff J.-N., Guigo R.,
RA Zody M.C., Mesirov J., Lindblad-Toh K., Birren B., Nusbaum C., Kahn D.,
RA Robinson-Rechavi M., Laudet V., Schachter V., Quetier F., Saurin W.,
RA Scarpelli C., Wincker P., Lander E.S., Weissenbach J., Roest Crollius H.;
RT "Genome duplication in the teleost fish Tetraodon nigroviridis reveals the
RT early vertebrate proto-karyotype.";
RL Nature 431:946-957(2004).
RN [2] {ECO:0000313|Ensembl:ENSTNIP00000003329.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR Ensembl; ENSTNIT00000003714.1; ENSTNIP00000003329.1; ENSTNIG00000019293.1.
DR GeneTree; ENSGT00940000155086; -.
DR HOGENOM; CLU_001183_3_1_1; -.
DR Proteomes; UP000007303; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR CDD; cd04011; C2B_Ferlin; 1.
DR CDD; cd04018; C2C_Ferlin; 1.
DR CDD; cd04017; C2D_Ferlin; 1.
DR CDD; cd04037; C2E_Ferlin; 1.
DR CDD; cd08374; C2F_Ferlin; 1.
DR Gene3D; 2.60.40.150; C2 domain; 5.
DR InterPro; IPR000008; C2_dom.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR037720; C2B_Ferlin.
DR InterPro; IPR037722; C2C_Ferlin.
DR InterPro; IPR037723; C2D_Ferlin.
DR InterPro; IPR037724; C2E_Ferlin.
DR InterPro; IPR037725; C2F_Ferlin.
DR InterPro; IPR012968; FerIin_dom.
DR InterPro; IPR037721; Ferlin.
DR InterPro; IPR012561; Ferlin_B-domain.
DR InterPro; IPR032362; Ferlin_C.
DR PANTHER; PTHR12546; FER-1-LIKE; 1.
DR PANTHER; PTHR12546:SF57; OTOFERLIN ISOFORM X1; 1.
DR Pfam; PF00168; C2; 5.
DR Pfam; PF08150; FerB; 1.
DR Pfam; PF08151; FerI; 1.
DR Pfam; PF16165; Ferlin_C; 1.
DR SMART; SM00239; C2; 5.
DR SMART; SM01201; FerB; 1.
DR SMART; SM01202; FerI; 1.
DR SUPFAM; SSF49562; C2 domain (Calcium/lipid-binding domain, CaLB); 6.
DR PROSITE; PS50004; C2; 6.
PE 4: Predicted;
KW Calcium {ECO:0000256|ARBA:ARBA00022837};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000007303};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 1609..1629
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 1..110
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT DOMAIN 153..284
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT DOMAIN 699..825
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT DOMAIN 872..998
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT DOMAIN 1117..1238
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT DOMAIN 1359..1510
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
SQ SEQUENCE 1644 AA; 187719 MW; A144DA6D8BD8F1CE CRC64;
SGRAVDYQVS VTVIEARQLV GQNMDPMVCV EIGEDKKYTS MKESTNCPYY NEYFVFDFHV
PPDVMYDKIL KLSVIHSKNL LRSGTLVGTF KLDVGTIYSQ PEHQFYHKWA LLSDPDDISA
GCKGYVKCDV SVVAKGDTMK TPHKASETDE DDIEGNLLLP DGVPAERQWA RYYLKIYRAE
GLPRMNTSIM ANVKKAFIGE NKDLVDPYVQ VQFAGQKGKT TVQKSCYEPI WNEQIIFTEM
FPPLCKRMKI QIRDSDKVND VAMGTHFLDL RKISNDGDRG EFTEQQAASS FTGVAVGRKF
EGFLPTLGPA WVNMYGSTRT YTLMDEYQEL NEGLGEGVSF RARLLISLAV EILDPSSPEM
TSSTEVQVEN ATGKVEEFFL FGSFLEATMI DRKIGDKPIN FEVTIGYYGN EIDGLAMPTK
KGKKEAGDEN YFHLPYLERK PCIFIKSWWQ DQRRRLYNAN IIDNIADKLE EGLNDVQEVI
KTEKAYPERR LRGVLEELSQ GCNYFLSLAN KDQNQSGRTR LDKERLKLCL LEIETIGQQA
KSMRSQVKKS TVREKIKQVQ NFLTKLRFLA DEPQHSIPDV FLWMISNGRR IAYARVPSKD
ILYSATEEER GKDCGKVKTI FLRIPGKKGF GPAGWTVQAK IEIYLWLGLN RQRKDYLSGL
PNGFEENRLS KGPGLPFSPP ISLSYMSKTI IYKQYSFTLQ YRDANPVCFP PVKQIFQLRV
HLYQARSLFA ADSTGLSDPF ARVFFSTQSQ VTEVLPETLC PTWDQLLVFE NVELFGEACE
LRDDPPIIVI ELYDQDTVGK ADFMGRTFAK PVVKMADEHY GPPRFPPQLE YYQIYRGNCC
AGELLAAFEL LQIGPNGKAD LPPIDGPTDM DRGPILPVPL GIRPVLSKYR IEVLFWGLRD
LKRVNLAQVD RPRVDIECAG KGVQSALIPN YKKNPNFSTL VKWFEVDLPE NELLHPPLNI
RVVDCRAFGR YTLVGSHAVT SLRKFIFRGS DKQANNWSTT VLEEIIVVSM ETEPAFKKME
TVDELDESML DWWSKYFASI ETLTETSLLK SACWSNKVYP KELESEFDNF EDWLHCFSLF
RGKGGDDDDQ NVTDEDRIVG KFKGSMCMYK VSDDVPRDHD SNMGMFQNIP SNDPINVLVR
IYVIRATDLH PADINGKADP YIAIKLGKTE IKDKENYISK QLNPLFGKSF DIEATFPMDS
TLTVSIYDWD LVGTDDLIGE TKLDLENRFY SKHRATCGIT SNYAIHGYNV WRDPMKPTQI
LAKLCKDGKL DGPHYGPGGR VKVENRVFMA PTEIEDENGL KKRTDEHLAL TVLKNWEEIP
RVGCKLIPEH VETRPLLHPD KPGIEQGRIE MWVDIFPKDM TAPGPALDIS PRKPKKFELR
VIIWNTDEVV LEDDDIFTGE KSSDIFVRGW LKGQQEDKQD TDVHYHSITG EGNFNWRLVY
PFDYLMAEEK IVISKKESMF AWDETEYKIP PRLNLQVWDA DHFSADDFLG AIELDLNRFP
RGAKTAKQCT IEMVTNEAEM PMVSIFKQKR IKGWWPFVAR NEEDEFELTG KVEAELHLLT
GEEAERNPVG LGRNEPEPLE KPNRPDTSLL WFLTPFKAIK HLICNQYKWL AIKIVTALLL
LAMLALFLYS MPGYMGIQLF SPSV
//
