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Database: UniProt
Entry: H3C5M2_TETNG
LinkDB: H3C5M2_TETNG
Original site: H3C5M2_TETNG 
ID   H3C5M2_TETNG            Unreviewed;      1231 AA.
AC   H3C5M2;
DT   18-APR-2012, integrated into UniProtKB/TrEMBL.
DT   18-APR-2012, sequence version 1.
DT   25-APR-2018, entry version 39.
DE   SubName: Full=Potassium large conductance calcium-activated channel, subfamily M, alpha member 1a {ECO:0000313|Ensembl:ENSTNIP00000003542};
OS   Tetraodon nigroviridis (Spotted green pufferfish) (Chelonodon
OS   nigroviridis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae;
OC   Tetraodon.
OX   NCBI_TaxID=99883 {ECO:0000313|Ensembl:ENSTNIP00000003542, ECO:0000313|Proteomes:UP000007303};
RN   [1] {ECO:0000313|Ensembl:ENSTNIP00000003542}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15496914; DOI=10.1038/nature03025;
RA   Jaillon O., Aury J.-M., Brunet F., Petit J.-L., Stange-Thomann N.,
RA   Mauceli E., Bouneau L., Fischer C., Ozouf-Costaz C., Bernot A.,
RA   Nicaud S., Jaffe D., Fisher S., Lutfalla G., Dossat C., Segurens B.,
RA   Dasilva C., Salanoubat M., Levy M., Boudet N., Castellano S.,
RA   Anthouard V., Jubin C., Castelli V., Katinka M., Vacherie B.,
RA   Biemont C., Skalli Z., Cattolico L., Poulain J., De Berardinis V.,
RA   Cruaud C., Duprat S., Brottier P., Coutanceau J.-P., Gouzy J.,
RA   Parra G., Lardier G., Chapple C., McKernan K.J., McEwan P., Bosak S.,
RA   Kellis M., Volff J.-N., Guigo R., Zody M.C., Mesirov J.,
RA   Lindblad-Toh K., Birren B., Nusbaum C., Kahn D., Robinson-Rechavi M.,
RA   Laudet V., Schachter V., Quetier F., Saurin W., Scarpelli C.,
RA   Wincker P., Lander E.S., Weissenbach J., Roest Crollius H.;
RT   "Genome duplication in the teleost fish Tetraodon nigroviridis reveals
RT   the early vertebrate proto-karyotype.";
RL   Nature 431:946-957(2004).
RN   [2] {ECO:0000313|Ensembl:ENSTNIP00000003542}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (FEB-2012) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the potassium channel family.
CC       {ECO:0000256|SAAS:SAAS00692852}.
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DR   Ensembl; ENSTNIT00000004020; ENSTNIP00000003542; ENSTNIG00000008628.
DR   eggNOG; KOG1420; Eukaryota.
DR   eggNOG; ENOG410YUX1; LUCA.
DR   GeneTree; ENSGT00530000063026; -.
DR   Proteomes; UP000007303; Unassembled WGS sequence.
DR   GO; GO:0008076; C:voltage-gated potassium channel complex; IEA:InterPro.
DR   GO; GO:0060072; F:large conductance calcium-activated potassium channel activity; IEA:InterPro.
DR   GO; GO:0005249; F:voltage-gated potassium channel activity; IEA:InterPro.
DR   GO; GO:0034765; P:regulation of ion transmembrane transport; IEA:UniProtKB-KW.
DR   Gene3D; 1.20.120.350; -; 1.
DR   InterPro; IPR024939; Ca-act_K_channel_Slo-1.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR003929; K_chnl_BK_asu.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   InterPro; IPR028325; VG_K_chnl.
DR   InterPro; IPR027359; Volt_channel_dom_sf.
DR   PANTHER; PTHR10027:SF28; PTHR10027:SF28; 1.
DR   Pfam; PF03493; BK_channel_a; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   PRINTS; PR00169; KCHANNEL.
DR   SUPFAM; SSF51735; SSF51735; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000007303};
KW   Ion channel {ECO:0000256|SAAS:SAAS00417203};
KW   Ion transport {ECO:0000256|SAAS:SAAS00417186};
KW   Membrane {ECO:0000256|SAAS:SAAS00085096, ECO:0000256|SAM:Phobius};
KW   Potassium {ECO:0000256|SAAS:SAAS00417282};
KW   Potassium channel {ECO:0000256|SAAS:SAAS00417246};
KW   Potassium transport {ECO:0000256|SAAS:SAAS00417240};
KW   Reference proteome {ECO:0000313|Proteomes:UP000007303};
KW   Transmembrane {ECO:0000256|SAAS:SAAS00084820,
KW   ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAAS:SAAS00084701,
KW   ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|SAAS:SAAS00417268};
KW   Voltage-gated channel {ECO:0000256|SAAS:SAAS00984201}.
FT   TRANSMEM     24     46       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    118    136       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    156    174       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    239    260       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    276    294       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    306    324       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN      119    330       Ion_trans. {ECO:0000259|Pfam:PF00520}.
SQ   SEQUENCE   1231 AA;  138773 MW;  FF4374387A7A8919 CRC64;
     MSKMEDVVIP YSSMVPCDNN GQRMWWAFLA SSMVTFFGGL FIILLWRTLK YLWTVCCHCN
     IKNKEAQKVN NPTNNQPAEK KKGPDEKEEA AASEVGWMTS VKDWAGVMIS AQTLTGRVLV
     VLVFALSIGA LGIYFIDSSD PIESCQNFYK DFTLQIDMAF NVFFLLYFGL RFIAANDKLW
     FWLEVNSVVD FFTVPPVFVS VYLNRSWLGL RFLRALRLIQ FSEILQFLNI LKTSNSIKLV
     NLCSIFISTW LTAAGFIHLV ENSGDPWENF QNSQSLSYWE CVYLLMVTMS TVGYGDVYAK
     TTLGRLFMVF FILGGLAMFA SYVPEIIELI GNRKKYGGSY SAVNGRKHIV VCGHITLESV
     SNFLKDFLHK DRDDVNVEIV FLHNISPNLE LEALFKRHFT QVEFYQGSVL NPHDLARVKI
     ESADACLILA NKYCADPDAE DASNIMRVIS IKNYHPKIRI ITQMLQYHNK AHLLNIPSWN
     WKEGDDAICL AELKAGFIAQ SCLAQGLSTM LANLFSMRSF IEIEEDTWQK YYLEGVANEM
     YTEYLSSAFV GLSFPTVCEL CYVKLKLLLI AIEYKSEQRE SRTPSILINP GNHVKMQEGT
     LGFFIASDAK EVKSIFYYCK ACHDDITDPK RIKKCGCKRP KMSVYKRMKL ACCFDCGRSE
     QDCSCMSGSV HSNMDTLQRA YPLSSVSVHD CATTLRAFED EHPSTLSPKK KQRNGGMRNS
     PNCSPKMMSR HDPLLIPGNE QIENMDMNVK RYDSTGMFHW CPSKEIEKVI LTRSEASMTV
     LSGHVVVCIF GDVTSALVGL RNLVMPLRAS NFHFHELKHI VFVGSLDYLR REWETLHNFP
     KVSILPGTPL SRADLRAVNI NLCDMCVILS ANQNNIEDAS LQDKECILAS LNIKSMQFDD
     SIGVLQANSQ GFTPPGMDRS SPESSPVHGF VRQASVTTGS NIPIITELVN DSNVQFLDQD
     DDDDPDTELY LTQPFACGTA FAVSVLDSLM SATYFNDNIL TLIRTLVTGG ATPELEALLA
     EENALRGGYS TPQTLANRDR CRVAQLALYD GPFADLGDGG CYGDLFCKAL KTYNMLCFGI
     YRLRDAHLST PSTCTKRYVI TNPPYEFELV PTDLIFCLMQ FDHNAGQSRT SLSHSSHSSH
     SSSKKSSSVH SVPPSNRQNR SSKTREARDK QNATRMNRMG QEKKWFTDEP DNAYPRNIQI
     KPMSTHMANQ VNQYKSTSSL IPPIREVEDE C
//
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