ID H3C639_TETNG Unreviewed; 1346 AA.
AC H3C639;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 1.
DT 24-JAN-2024, entry version 44.
DE RecName: Full=EvC ciliary complex subunit 2 {ECO:0008006|Google:ProtNLM};
OS Tetraodon nigroviridis (Spotted green pufferfish) (Chelonodon
OS nigroviridis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Tetraodon.
OX NCBI_TaxID=99883 {ECO:0000313|Ensembl:ENSTNIP00000003709.1, ECO:0000313|Proteomes:UP000007303};
RN [1] {ECO:0000313|Proteomes:UP000007303}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15496914; DOI=10.1038/nature03025;
RA Jaillon O., Aury J.-M., Brunet F., Petit J.-L., Stange-Thomann N.,
RA Mauceli E., Bouneau L., Fischer C., Ozouf-Costaz C., Bernot A., Nicaud S.,
RA Jaffe D., Fisher S., Lutfalla G., Dossat C., Segurens B., Dasilva C.,
RA Salanoubat M., Levy M., Boudet N., Castellano S., Anthouard V., Jubin C.,
RA Castelli V., Katinka M., Vacherie B., Biemont C., Skalli Z., Cattolico L.,
RA Poulain J., De Berardinis V., Cruaud C., Duprat S., Brottier P.,
RA Coutanceau J.-P., Gouzy J., Parra G., Lardier G., Chapple C.,
RA McKernan K.J., McEwan P., Bosak S., Kellis M., Volff J.-N., Guigo R.,
RA Zody M.C., Mesirov J., Lindblad-Toh K., Birren B., Nusbaum C., Kahn D.,
RA Robinson-Rechavi M., Laudet V., Schachter V., Quetier F., Saurin W.,
RA Scarpelli C., Wincker P., Lander E.S., Weissenbach J., Roest Crollius H.;
RT "Genome duplication in the teleost fish Tetraodon nigroviridis reveals the
RT early vertebrate proto-karyotype.";
RL Nature 431:946-957(2004).
RN [2] {ECO:0000313|Ensembl:ENSTNIP00000003709.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (JUL-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell projection, cilium membrane
CC {ECO:0000256|ARBA:ARBA00004309}. Membrane
CC {ECO:0000256|ARBA:ARBA00004370}.
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DR Ensembl; ENSTNIT00000001690.1; ENSTNIP00000003709.1; ENSTNIG00000010998.1.
DR GeneTree; ENSGT00940000154127; -.
DR InParanoid; H3C639; -.
DR Proteomes; UP000007303; Unassembled WGS sequence.
DR GO; GO:0060170; C:ciliary membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-KW.
DR GO; GO:0007224; P:smoothened signaling pathway; IEA:InterPro.
DR InterPro; IPR022076; Limbin.
DR InterPro; IPR026501; Limbin/EVC.
DR PANTHER; PTHR16795:SF14; LIMBIN; 1.
DR PANTHER; PTHR16795; LIMBIN/ELLIS-VAN CREVELD PROTEIN; 1.
DR Pfam; PF12297; EVC2_like; 1.
PE 4: Predicted;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Cell projection {ECO:0000256|ARBA:ARBA00023273};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000007303};
KW Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..24
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 25..1346
FT /note="EvC ciliary complex subunit 2"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5003581994"
FT TRANSMEM 302..323
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REGION 1242..1346
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 1024..1051
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 1249..1265
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1266..1281
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1346 AA; 152052 MW; DA98AAAFCF481DB1 CRC64;
MLLGQLFASN VAVLCLVLTF RVLCLLPPPL PFGCYDNVSG HTGVLEHISG HQCCDATCRD
ASNWAASSSP AEKQSLFKLH IMQHHHVKAA ERSLPRMDGT VERTGSAPSP VSSAAVGPWQ
HSFSKSFGFV SKMLHIQRGR GTLTEYNSGF SLPQVQSAAP SFAFGVKFHK CAQVKLDSEP
PQLTFYLMVD NSGPVLGSGT NLSQVAIRDS TSGIVPIRTE GRVVERGYQI FAIDSLSAGS
QVIVNYTAHI RSHKIDLLDL PAFLTFSNAS QNDVSMFGPL TANLTLRVNS TDRIQPNHDA
HFAGFVVGFF VTIVLLSLGF LAINLTDSRT RLNILQQNKK RRDSDINNAD CDLDESFKEE
AAFEDKIVDI MVLKRGFHCM NNSTSLEMST LLRATNNLEV TRIQIYKDVM SLLLGDLPSR
GHTSVQTQQR LLSVLDGQLL GMEGRLKEER GARMTALANR CNLESREEME AEHHREAAEK
AQAKLLCKQA DQQELLHCSV LMEKLHKLKQ SQLQDKLLVQ HEEASAKVQR QIIEWRRVEL
HKIFSEELEE STRMGEMERK TAESLQHEYF DCQDYLEEVL DMILANQRYV LAERHAQRKF
LVHSLHSLNG LISDTFSITS DSLDNWFSQI KRGSTLPAEQ VDQLQDKAQK ELVMVRQRLD
ETMSQEKRSM RCGLVKKRRE LLSDMLRVHR QRQNELSGMS KDLERKMEVA RHLQCWQNLL
TAHSLELAEL INNLDEEAAA DIRKVTMRVI QSALNEVKAI QPSAAQDLLA LLPPGTPHTL
LQIEHEAERP GQAQGVNSLQ QGQEKLHQEG KTALHTLRCT RVALQETMEK ELQEQRERRA
HSRAFFSCLC SSQVSLCEED RLKMKLEFLK CLSVMDRCLV LPHAVSKKKL HTALVAETFQ
HTGMCRNIKF KWKTRPKREQ TAPADLLLFQ KRLEARIQLF QELKEMESVA MNKVKEEMQR
EREDDLRSGV DSVAMQMAAL HYQKAERNTK VLETTRAALT LHGLLIQNLS ERKNPDRQNM
AQCIQNHCLA LEEAEQRLQK KRTELEELLT SRAGPKSDPA ADCDEREEER LFQVQRDCLM
ASIVQDALYK REQVILLLAE RLQEMTCNTQ AMEDLKEQMR LTKLEANCDQ DLLFASQLVK
QSQVSAEVLL EALRLLLPVL PESELLSITD ALRSKQQQDP TLAEQEQSEF AEKTNRLIPA
KLRADALEDH APQIVNCAAD EARLQERRQS LMGKLLPRSR FPVLRNVAPP RAEDKEKDDR
LTADRSDSSN SATQASVDGG SRRSRRTAEY GTHASAGLGP SSPATAGKLF VFRDPPQSCD
LAGPPRRKRK NFLNLKKSSV APTDLP
//