ID H3C6G0_TETNG Unreviewed; 1146 AA.
AC H3C6G0;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 1.
DT 27-MAR-2024, entry version 75.
DE SubName: Full=Fibulin 2 {ECO:0000313|Ensembl:ENSTNIP00000003830.1};
GN Name=FBLN2 {ECO:0000313|Ensembl:ENSTNIP00000003830.1};
OS Tetraodon nigroviridis (Spotted green pufferfish) (Chelonodon
OS nigroviridis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Tetraodon.
OX NCBI_TaxID=99883 {ECO:0000313|Ensembl:ENSTNIP00000003830.1, ECO:0000313|Proteomes:UP000007303};
RN [1] {ECO:0000313|Proteomes:UP000007303}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15496914; DOI=10.1038/nature03025;
RA Jaillon O., Aury J.-M., Brunet F., Petit J.-L., Stange-Thomann N.,
RA Mauceli E., Bouneau L., Fischer C., Ozouf-Costaz C., Bernot A., Nicaud S.,
RA Jaffe D., Fisher S., Lutfalla G., Dossat C., Segurens B., Dasilva C.,
RA Salanoubat M., Levy M., Boudet N., Castellano S., Anthouard V., Jubin C.,
RA Castelli V., Katinka M., Vacherie B., Biemont C., Skalli Z., Cattolico L.,
RA Poulain J., De Berardinis V., Cruaud C., Duprat S., Brottier P.,
RA Coutanceau J.-P., Gouzy J., Parra G., Lardier G., Chapple C.,
RA McKernan K.J., McEwan P., Bosak S., Kellis M., Volff J.-N., Guigo R.,
RA Zody M.C., Mesirov J., Lindblad-Toh K., Birren B., Nusbaum C., Kahn D.,
RA Robinson-Rechavi M., Laudet V., Schachter V., Quetier F., Saurin W.,
RA Scarpelli C., Wincker P., Lander E.S., Weissenbach J., Roest Crollius H.;
RT "Genome duplication in the teleost fish Tetraodon nigroviridis reveals the
RT early vertebrate proto-karyotype.";
RL Nature 431:946-957(2004).
RN [2] {ECO:0000313|Ensembl:ENSTNIP00000003830.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular
CC matrix {ECO:0000256|ARBA:ARBA00004498}.
CC -!- SIMILARITY: Belongs to the fibulin family.
CC {ECO:0000256|ARBA:ARBA00006127}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR AlphaFoldDB; H3C6G0; -.
DR STRING; 99883.ENSTNIP00000003830; -.
DR Ensembl; ENSTNIT00000003632.1; ENSTNIP00000003830.1; ENSTNIG00000017936.1.
DR GeneTree; ENSGT00940000156047; -.
DR InParanoid; H3C6G0; -.
DR OMA; MNTCRDI; -.
DR TreeFam; TF317514; -.
DR Proteomes; UP000007303; Unassembled WGS sequence.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0048513; P:animal organ development; IEA:UniProt.
DR CDD; cd00054; EGF_CA; 4.
DR Gene3D; 2.10.25.10; Laminin; 10.
DR InterPro; IPR000020; Anaphylatoxin/fibulin.
DR InterPro; IPR026823; cEGF.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR InterPro; IPR018097; EGF_Ca-bd_CS.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR PANTHER; PTHR24034; EGF-LIKE DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR24034:SF196; RE64043P; 1.
DR Pfam; PF12662; cEGF; 1.
DR Pfam; PF07645; EGF_CA; 6.
DR Pfam; PF14670; FXa_inhibition; 1.
DR SMART; SM00104; ANATO; 2.
DR SMART; SM00181; EGF; 10.
DR SMART; SM00179; EGF_CA; 10.
DR SUPFAM; SSF57196; EGF/Laminin; 1.
DR SUPFAM; SSF57184; Growth factor receptor domain; 4.
DR PROSITE; PS01177; ANAPHYLATOXIN_1; 1.
DR PROSITE; PS01178; ANAPHYLATOXIN_2; 2.
DR PROSITE; PS00010; ASX_HYDROXYL; 4.
DR PROSITE; PS01186; EGF_2; 4.
DR PROSITE; PS50026; EGF_3; 3.
DR PROSITE; PS01187; EGF_CA; 4.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; Extracellular matrix {ECO:0000256|ARBA:ARBA00022530};
KW Reference proteome {ECO:0000313|Proteomes:UP000007303};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Secreted {ECO:0000256|ARBA:ARBA00022525}.
FT DOMAIN 442..473
FT /note="Anaphylatoxin-like"
FT /evidence="ECO:0000259|PROSITE:PS01178"
FT DOMAIN 475..507
FT /note="Anaphylatoxin-like"
FT /evidence="ECO:0000259|PROSITE:PS01178"
FT DOMAIN 566..607
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 817..855
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 905..943
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT REGION 209..228
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 234..314
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 332..353
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 615..646
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 214..228
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 248..265
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 268..301
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 628..646
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1146 AA; 125856 MW; B9BD56A83BF4F1D1 CRC64;
RDCTGVDCPP VDNCLQTTLE VGACCPTCTQ RGCTCEGYQY YDCIHAGFQK GKVPEGESYF
VDFGSTECSC PQGGGKISCH FIPCPELPSN CIDILQPEDG CLQCERIGCT HGNKKYEAGH
SFQMDQCHVC HCPNEGGKLM CSLIPGCDLR GSNKPVRVGV TTTEDNSRFR EINSRPDTSQ
VSPMEPHSKL ALGNTLPLYK QDPPGFGTVK YDDTLAGPTS SSVQKLAQPL ESTTVPAAFP
EPNSTSSSSH DEQRHELREP QETREAAVTQ DIGPTTTEAQ SKPTTVLTTT QEVTTEDLRP
QQEAGKSPLE HHLQSPGVLQ VPLKDVFHTA HPREQKPSQG PPSRSHASFH SEVEDEESQH
LFLIYGLRTE NRLDPVSVHG LIGPPLNGVS AKELVQTCCE TGEKWASSNG HCNDMEPPTK
DMHSICWTAQ RQCCVGSLGE TQCLAGINAA RGGEACPKKV SNNCETDSYK ECCDCCFLGL
QLRSEGRRCE PHRYLGFHCR HVFLTCCEGE EGSHEERYSA VRERPTFTSS PPLQKISDSP
YPREAFFIGE EQDGGNAVED PIEGEDTNEC LIYEGNICHH RCINTPGSFR CECFPGYVLQ
EDAFTCVPGN EAVEEDNRLK ETEGPAVKPT SPLPPPTEPP APADPCQGNS PCQQQCTSVG
GRPHCSCFPG FSLMTDGVSC MDVNECLSGR VCKLNQLCVN TVGSYVCQRL IICPPGYQIS
NDICEDINEC VQQSHNCGQD QECVNTEGSF RCNSKPRCPL GFNRESAGTD TDECGASSQT
CSPAFNCINT VGSFVCQRKL VCSRGYHSSP DGSKCVDVDE CQSGAHRCGG GQLCHNLPGS
YRCECQTGYE YNSFRRMCVG TSDRCWRYSG RVCAQTCENT PGSYECSCTS GFRLSSDGKN
CESPDVNECL ASPCSQECAN IYGSYQCYCR QGYFLRQDGH TCDDIDECSQ SIGHLCTYKC
VNVPGSYQCA CPEYGYTMSA NGRSCRDVDE CTTGAHNCSV AETCYNIQGG YRCLSLSCPP
NYRKVSDTRC ERINCPNYLE CQNSPLRITY YYLSFQSNIV VPAQIFRIGP SPAYSGDNVI
ISITQGNEDS YFSTRKLNAY TGAVYLQRQV EGPRDFLINV EMKLWRQGTF TTFHARIYVF
ITGNSV
//