ID H3C6H1_TETNG Unreviewed; 532 AA.
AC H3C6H1;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 1.
DT 27-MAR-2024, entry version 52.
DE SubName: Full=Toll-like receptor adaptor molecule 1 {ECO:0000313|Ensembl:ENSTNIP00000003841.1};
OS Tetraodon nigroviridis (Spotted green pufferfish) (Chelonodon
OS nigroviridis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Tetraodon.
OX NCBI_TaxID=99883 {ECO:0000313|Ensembl:ENSTNIP00000003841.1, ECO:0000313|Proteomes:UP000007303};
RN [1] {ECO:0000313|Proteomes:UP000007303}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15496914; DOI=10.1038/nature03025;
RA Jaillon O., Aury J.-M., Brunet F., Petit J.-L., Stange-Thomann N.,
RA Mauceli E., Bouneau L., Fischer C., Ozouf-Costaz C., Bernot A., Nicaud S.,
RA Jaffe D., Fisher S., Lutfalla G., Dossat C., Segurens B., Dasilva C.,
RA Salanoubat M., Levy M., Boudet N., Castellano S., Anthouard V., Jubin C.,
RA Castelli V., Katinka M., Vacherie B., Biemont C., Skalli Z., Cattolico L.,
RA Poulain J., De Berardinis V., Cruaud C., Duprat S., Brottier P.,
RA Coutanceau J.-P., Gouzy J., Parra G., Lardier G., Chapple C.,
RA McKernan K.J., McEwan P., Bosak S., Kellis M., Volff J.-N., Guigo R.,
RA Zody M.C., Mesirov J., Lindblad-Toh K., Birren B., Nusbaum C., Kahn D.,
RA Robinson-Rechavi M., Laudet V., Schachter V., Quetier F., Saurin W.,
RA Scarpelli C., Wincker P., Lander E.S., Weissenbach J., Roest Crollius H.;
RT "Genome duplication in the teleost fish Tetraodon nigroviridis reveals the
RT early vertebrate proto-karyotype.";
RL Nature 431:946-957(2004).
RN [2] {ECO:0000313|Ensembl:ENSTNIP00000003841.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR AlphaFoldDB; H3C6H1; -.
DR STRING; 99883.ENSTNIP00000003841; -.
DR Ensembl; ENSTNIT00000001361.1; ENSTNIP00000003841.1; ENSTNIG00000001099.1.
DR GeneTree; ENSGT00940000163706; -.
DR HOGENOM; CLU_481409_0_0_1; -.
DR InParanoid; H3C6H1; -.
DR OMA; TRHGWQD; -.
DR TreeFam; TF336953; -.
DR Proteomes; UP000007303; Unassembled WGS sequence.
DR GO; GO:0005794; C:Golgi apparatus; IEA:Ensembl.
DR GO; GO:0043123; P:positive regulation of canonical NF-kappaB signal transduction; IEA:Ensembl.
DR GO; GO:0032728; P:positive regulation of interferon-beta production; IEA:Ensembl.
DR GO; GO:0035666; P:TRIF-dependent toll-like receptor signaling pathway; IEA:InterPro.
DR Gene3D; 1.25.40.780; -; 1.
DR Gene3D; 3.40.50.10140; Toll/interleukin-1 receptor homology (TIR) domain; 1.
DR InterPro; IPR046946; TCAM1/2.
DR InterPro; IPR000157; TIR_dom.
DR InterPro; IPR035897; Toll_tir_struct_dom_sf.
DR InterPro; IPR040886; TRIF_N.
DR PANTHER; PTHR47230; TIR DOMAIN-CONTAINING ADAPTER MOLECULE 1; 1.
DR PANTHER; PTHR47230:SF1; TIR DOMAIN-CONTAINING ADAPTER MOLECULE 1; 1.
DR Pfam; PF17798; TRIF-NTD; 1.
DR PROSITE; PS50104; TIR; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000007303}.
FT DOMAIN 305..441
FT /note="TIR"
FT /evidence="ECO:0000259|PROSITE:PS50104"
SQ SEQUENCE 532 AA; 59221 MW; 8FD8390E940A176C CRC64;
MSHGGHNNQG TGPGDILDIL VKTPLERLLS LTLQPSESPE GNVVHVLCLI VLQREKQALG
KLHTLGNSLL SKHLSETWLM SRGKLEDFAL SFRNFQNLTS ESVVLLARVF KVLSEQRLCD
PHLRDVAYRR ALSTVGHTSE PLGYEQLKEE AVAVCGPQVA EWMCSYVSGL GSLSVLDSNR
LPSPLDANPS TLSYPTHLEI STSSTAFVKE DRTPETPQTP QANPSVLLRT NEVGTKDASE
PCPVSEEPQL KSSEFAGDSL VLSSLPASTF ATGPSFAAPS TYVPAETRAA CDLEESGSTG
EEEATFYGFV IMHAPEDADA ADDVREKMEK IIDCKGATFS DDFHVPGKST LGCVEDAINN
TAFTILLLTQ NFTTRMVELQ TSSALINSLN RKHKWNTVIP LLPLHNCMPK QDIPLILQTI
VPLQENKNFE RKILKSISLQ KIKRQEKIWM EEQRMKLLKA RQQQLKHQKQ LMKESEKAQW
QEKERLRLQL GQPLLNPNVL GEDDEDGRAW WQHSNIHIES ANYIIIGNDS QM
//
