ID H3C8U9_TETNG Unreviewed; 1621 AA.
AC H3C8U9;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 1.
DT 27-MAR-2024, entry version 65.
DE SubName: Full=Ankyrin 1 {ECO:0000313|Ensembl:ENSTNIP00000004671.1};
GN Name=ANK1 {ECO:0000313|Ensembl:ENSTNIP00000004671.1};
OS Tetraodon nigroviridis (Spotted green pufferfish) (Chelonodon
OS nigroviridis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Tetraodon.
OX NCBI_TaxID=99883 {ECO:0000313|Ensembl:ENSTNIP00000004671.1, ECO:0000313|Proteomes:UP000007303};
RN [1] {ECO:0000313|Proteomes:UP000007303}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15496914; DOI=10.1038/nature03025;
RA Jaillon O., Aury J.-M., Brunet F., Petit J.-L., Stange-Thomann N.,
RA Mauceli E., Bouneau L., Fischer C., Ozouf-Costaz C., Bernot A., Nicaud S.,
RA Jaffe D., Fisher S., Lutfalla G., Dossat C., Segurens B., Dasilva C.,
RA Salanoubat M., Levy M., Boudet N., Castellano S., Anthouard V., Jubin C.,
RA Castelli V., Katinka M., Vacherie B., Biemont C., Skalli Z., Cattolico L.,
RA Poulain J., De Berardinis V., Cruaud C., Duprat S., Brottier P.,
RA Coutanceau J.-P., Gouzy J., Parra G., Lardier G., Chapple C.,
RA McKernan K.J., McEwan P., Bosak S., Kellis M., Volff J.-N., Guigo R.,
RA Zody M.C., Mesirov J., Lindblad-Toh K., Birren B., Nusbaum C., Kahn D.,
RA Robinson-Rechavi M., Laudet V., Schachter V., Quetier F., Saurin W.,
RA Scarpelli C., Wincker P., Lander E.S., Weissenbach J., Roest Crollius H.;
RT "Genome duplication in the teleost fish Tetraodon nigroviridis reveals the
RT early vertebrate proto-karyotype.";
RL Nature 431:946-957(2004).
RN [2] {ECO:0000313|Ensembl:ENSTNIP00000004671.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton
CC {ECO:0000256|ARBA:ARBA00004245}. Membrane
CC {ECO:0000256|ARBA:ARBA00004370}.
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DR Ensembl; ENSTNIT00000004814.1; ENSTNIP00000004671.1; ENSTNIG00000005321.1.
DR GeneTree; ENSGT00940000155760; -.
DR HOGENOM; CLU_000134_7_3_1; -.
DR Proteomes; UP000007303; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0051179; P:localization; IEA:UniProt.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR Gene3D; 2.60.220.30; -; 2.
DR Gene3D; 2.60.40.2660; -; 1.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 3.
DR Gene3D; 1.10.533.10; Death Domain, Fas; 1.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR040745; Ankyrin_UPA.
DR InterPro; IPR011029; DEATH-like_dom_sf.
DR InterPro; IPR000488; Death_domain.
DR InterPro; IPR000906; ZU5_dom.
DR PANTHER; PTHR24198; ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR24198:SF173; ANKYRIN-3; 1.
DR Pfam; PF00023; Ank; 3.
DR Pfam; PF12796; Ank_2; 6.
DR Pfam; PF13637; Ank_4; 3.
DR Pfam; PF00531; Death; 1.
DR Pfam; PF17809; UPA_2; 1.
DR Pfam; PF00791; ZU5; 2.
DR PRINTS; PR01415; ANKYRIN.
DR SMART; SM00248; ANK; 23.
DR SMART; SM00005; DEATH; 1.
DR SMART; SM00218; ZU5; 1.
DR SUPFAM; SSF48403; Ankyrin repeat; 3.
DR SUPFAM; SSF47986; DEATH domain; 1.
DR PROSITE; PS50297; ANK_REP_REGION; 21.
DR PROSITE; PS50088; ANK_REPEAT; 21.
DR PROSITE; PS50017; DEATH_DOMAIN; 1.
DR PROSITE; PS51145; ZU5; 2.
PE 4: Predicted;
KW ANK repeat {ECO:0000256|ARBA:ARBA00023043, ECO:0000256|PROSITE-
KW ProRule:PRU00023}; Cytoplasm {ECO:0000256|ARBA:ARBA00023212};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000007303};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT REPEAT 58..90
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 91..123
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 124..156
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 157..181
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 219..251
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 252..284
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 285..317
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 318..350
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 351..383
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 384..416
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 417..449
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 450..482
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 483..515
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 516..548
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 549..581
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 582..614
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 615..647
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 648..680
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 681..713
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 714..746
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 747..779
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT DOMAIN 945..1100
FT /note="ZU5"
FT /evidence="ECO:0000259|PROSITE:PS51145"
FT DOMAIN 1102..1248
FT /note="ZU5"
FT /evidence="ECO:0000259|PROSITE:PS51145"
FT DOMAIN 1444..1511
FT /note="Death"
FT /evidence="ECO:0000259|PROSITE:PS50017"
FT REGION 1..21
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 915..935
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1602..1621
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1621 AA; 176568 MW; B89D954356C7CE02 CRC64;
MLSNEERRSA ARRLAAKTSG KMQADASTSF LRAARSGNLE KALDHIRNGI DINTANQNGL
NGLHLASKEG HVKMVLELLH AGIELEATTK KGNTALHIAA LAGQEKVVAE LINYGANVNA
QSHKGFSPLY MAAQENHLEV VKFLLENGAN QSLPTEDGFT PLAVALQQGH ENVVALLINY
GTKGKVRLPA LHIAARNDDT RTAAVLLQND PNADVLSKTG FTPLHIAAHY ENMSVAQLLL
NRGANVNFTP KNGITPLHIA SRRGNVMMVR LLLDRGAQID AKTKDELTPL HCAARNGHVR
IIEILLEHGA PIQAKTKNGL SPIHMAAQGD HMDGVRQLLQ FNADIDDITL DHLTPLHVAA
HCGHHRMVKV LLDKGAKANA RALNGFTPLH IACKKNHMRS LDLLLKHSAS LEAVTESGLT
PLHVAAFMGH LNIVKTLLQR GASPNASNVK VETPLHMASR AGHCEVAQFL LQNTAQVDAK
AKDDQTPLHC AARMGHKELV KLLLDHRANP DSATTAGHTP LHICAREGHM HIIRILLDAG
AQQTRMTKKG FTSLHVASKY GQVGVAELLL DRGANANAAG KNGLTPLHVA VHHNNLDVVK
LLVSKGGSAH STARNGYTPL HIAAKQNQME VASCLLQSGA TPNAESLQGI TPLHLAAQEG
RPDIAALLLS KQANVNVGNK NGLTPLHLVA QEGHVGIADM LVKQGASIYA ATRMGYTPLH
VACHYGNIKM VKFLLQQQAH VNSKTRMGYT PLHQAAQQGH TDIVTLLLKH GAQPNEITSK
NGTSPLGIAK RLGYISVIDV LKLVTEESVS AVTTEKHWMS FPETVDEILD VSEDEGDELL
GMDGGRYLKL DDFKDQDEDF LSPKKTLRDF EGGVGTTFNR FLSHRPYSPA IPRIPCVSPE
TVLLDQHTPV PLPKEYDEDS LIPSSPATET SDNVSPVASP IHTGFLVSFM VDARGGSMRG
SRHHGLRIII PPRTCTAPTR ITCRLVKPQK LTTPPPLVEG EGLASRIISL GPSSMQFLGP
VIVEIPHFAS LGRGDRELVV LRSENGSVWK EHRNRYGDEV LETILNGMDE DLESLEELEK
KRIRRILSTD FPLYFAVVSR IQQESDLIGP EGGRLSSRLV PHVEAIFPEA AVTKRVRLGL
QAQPIPDELL TRQLGNQATF SPVVTIEPRR RKFHRPIGLR IPLPPSWRES PRDAGEGDTT
SLRLLCSVIG GTAPAQWEDI TGTTKLMYAS NCANFTTNVS ARFWLADCPR TAEAVAFANL
LHRELMAVPY MAKFVVFAKM NEAREGRLRC YCMTDDKMDK TLELHENFAE VARSRDIELM
EGMPLHLECS GNLVPVRKAT QQPRSFSFQA FRDNRLPVAV KVRDANKEAS GFLSFLRKCT
KYEDTQHVLC NLNIAMPPCI KVVGSEERKR TLTPLALTVV NAMERAELKI SLISEQLGLS
WAAELARELH FGVDDINRIR VENPNSLLDQ SAALLGLWAG REGRRAKMES LCTALKNIDR
ADIVAALEAP PPTAGSSDGT SHWSSQASSL ACPPSGFGLV QDELLSPASM QYSLPSPLGA
EPYWQEVSSL ECAPMATTEE DTLMEMSELQ VWPAGLSPSL VTVEDSSLEG SSRADDSEGA
T
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