ID H3C8V9_TETNG Unreviewed; 444 AA.
AC H3C8V9;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 1.
DT 27-MAR-2024, entry version 60.
DE RecName: Full=Tubby-like protein {ECO:0000256|RuleBase:RU361125};
OS Tetraodon nigroviridis (Spotted green pufferfish) (Chelonodon
OS nigroviridis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Tetraodon.
OX NCBI_TaxID=99883 {ECO:0000313|Ensembl:ENSTNIP00000004681.1, ECO:0000313|Proteomes:UP000007303};
RN [1] {ECO:0000313|Proteomes:UP000007303}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15496914; DOI=10.1038/nature03025;
RA Jaillon O., Aury J.-M., Brunet F., Petit J.-L., Stange-Thomann N.,
RA Mauceli E., Bouneau L., Fischer C., Ozouf-Costaz C., Bernot A., Nicaud S.,
RA Jaffe D., Fisher S., Lutfalla G., Dossat C., Segurens B., Dasilva C.,
RA Salanoubat M., Levy M., Boudet N., Castellano S., Anthouard V., Jubin C.,
RA Castelli V., Katinka M., Vacherie B., Biemont C., Skalli Z., Cattolico L.,
RA Poulain J., De Berardinis V., Cruaud C., Duprat S., Brottier P.,
RA Coutanceau J.-P., Gouzy J., Parra G., Lardier G., Chapple C.,
RA McKernan K.J., McEwan P., Bosak S., Kellis M., Volff J.-N., Guigo R.,
RA Zody M.C., Mesirov J., Lindblad-Toh K., Birren B., Nusbaum C., Kahn D.,
RA Robinson-Rechavi M., Laudet V., Schachter V., Quetier F., Saurin W.,
RA Scarpelli C., Wincker P., Lander E.S., Weissenbach J., Roest Crollius H.;
RT "Genome duplication in the teleost fish Tetraodon nigroviridis reveals the
RT early vertebrate proto-karyotype.";
RL Nature 431:946-957(2004).
RN [2] {ECO:0000313|Ensembl:ENSTNIP00000004681.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- SIMILARITY: Belongs to the TUB family. {ECO:0000256|ARBA:ARBA00007129,
CC ECO:0000256|RuleBase:RU361125}.
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DR AlphaFoldDB; H3C8V9; -.
DR STRING; 99883.ENSTNIP00000004681; -.
DR Ensembl; ENSTNIT00000004824.1; ENSTNIP00000004681.1; ENSTNIG00000002223.1.
DR GeneTree; ENSGT00940000158155; -.
DR HOGENOM; CLU_028236_1_1_1; -.
DR InParanoid; H3C8V9; -.
DR OMA; FPTYFMH; -.
DR TreeFam; TF314076; -.
DR Proteomes; UP000007303; Unassembled WGS sequence.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR InterPro; IPR025659; Tubby-like_C.
DR InterPro; IPR000007; Tubby_C.
DR InterPro; IPR018066; Tubby_C_CS.
DR InterPro; IPR005398; Tubby_N.
DR PANTHER; PTHR16517:SF167; TUBBY-LIKE PROTEIN; 1.
DR PANTHER; PTHR16517; TUBBY-RELATED; 1.
DR Pfam; PF01167; Tub; 1.
DR Pfam; PF16322; Tub_N; 2.
DR PRINTS; PR01573; SUPERTUBBY.
DR PRINTS; PR01574; TUBBYPROTEIN.
DR SUPFAM; SSF54518; Tubby C-terminal domain-like; 1.
DR PROSITE; PS01200; TUB_1; 1.
DR PROSITE; PS01201; TUB_2; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000007303};
KW Secreted {ECO:0000256|ARBA:ARBA00022525}.
FT DOMAIN 29..82
FT /note="Tubby N-terminal"
FT /evidence="ECO:0000259|Pfam:PF16322"
FT DOMAIN 84..174
FT /note="Tubby N-terminal"
FT /evidence="ECO:0000259|Pfam:PF16322"
FT DOMAIN 194..438
FT /note="Tubby C-terminal"
FT /evidence="ECO:0000259|Pfam:PF01167"
FT REGION 36..73
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 92..181
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 55..69
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 444 AA; 49098 MW; 4BC0F76D1787F1CF CRC64;
AVMRHSSLYV NTSAIDGDDS SLMRQKLDRQ RALLEQKQRR KRQEPLMVQP NTEARPRRAR
TRRGEEQAPL VESQLHVSND VALDGIDGPA AFLASEAPDP GTRVHTASAK QGESPGPAEP
ARSGRQAGGR DLSVSAPAGL SGSMNFDESS GPEDDTDEER TPSLSPSGTR PDPPRPPATD
AATLDASNLE EFVFRPAPRG VTVKCRISRN KKGMDRGLYP TYFMHMERED GKRVFLLAGR
KRKKSKTSNY LMSVDATDLS RGGESFIGKL RSNLMGTKFT VFDNGSSPGK NPGALLEEGG
KRQELAAICY ETNVLGFNGP RKMTVVIPGM NMNFERVPVR PQNEQESILS RWHSRSLDNL
IELHNKAPVW NEDTQSYVLN FHGRVTQASV KNFQIVHDND PEYIVMQFGR VAEDIFTLDY
NYPMCALQAF AIGLSSFDGK LACE
//
