ID H3CAF7_TETNG Unreviewed; 1192 AA.
AC H3CAF7;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 1.
DT 27-MAR-2024, entry version 68.
DE SubName: Full=Integrin, alpha 11b {ECO:0000313|Ensembl:ENSTNIP00000005229.1};
OS Tetraodon nigroviridis (Spotted green pufferfish) (Chelonodon
OS nigroviridis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Tetraodon.
OX NCBI_TaxID=99883 {ECO:0000313|Ensembl:ENSTNIP00000005229.1, ECO:0000313|Proteomes:UP000007303};
RN [1] {ECO:0000313|Proteomes:UP000007303}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15496914; DOI=10.1038/nature03025;
RA Jaillon O., Aury J.-M., Brunet F., Petit J.-L., Stange-Thomann N.,
RA Mauceli E., Bouneau L., Fischer C., Ozouf-Costaz C., Bernot A., Nicaud S.,
RA Jaffe D., Fisher S., Lutfalla G., Dossat C., Segurens B., Dasilva C.,
RA Salanoubat M., Levy M., Boudet N., Castellano S., Anthouard V., Jubin C.,
RA Castelli V., Katinka M., Vacherie B., Biemont C., Skalli Z., Cattolico L.,
RA Poulain J., De Berardinis V., Cruaud C., Duprat S., Brottier P.,
RA Coutanceau J.-P., Gouzy J., Parra G., Lardier G., Chapple C.,
RA McKernan K.J., McEwan P., Bosak S., Kellis M., Volff J.-N., Guigo R.,
RA Zody M.C., Mesirov J., Lindblad-Toh K., Birren B., Nusbaum C., Kahn D.,
RA Robinson-Rechavi M., Laudet V., Schachter V., Quetier F., Saurin W.,
RA Scarpelli C., Wincker P., Lander E.S., Weissenbach J., Roest Crollius H.;
RT "Genome duplication in the teleost fish Tetraodon nigroviridis reveals the
RT early vertebrate proto-karyotype.";
RL Nature 431:946-957(2004).
RN [2] {ECO:0000313|Ensembl:ENSTNIP00000005229.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479,
CC ECO:0000256|RuleBase:RU003762}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004479, ECO:0000256|RuleBase:RU003762}.
CC -!- SIMILARITY: Belongs to the integrin alpha chain family.
CC {ECO:0000256|ARBA:ARBA00008054, ECO:0000256|RuleBase:RU003762}.
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DR AlphaFoldDB; H3CAF7; -.
DR STRING; 99883.ENSTNIP00000005229; -.
DR Ensembl; ENSTNIT00000005375.1; ENSTNIP00000005229.1; ENSTNIG00000002675.1.
DR GeneTree; ENSGT00940000155465; -.
DR HOGENOM; CLU_004111_2_1_1; -.
DR InParanoid; H3CAF7; -.
DR OMA; AQHSQRK; -.
DR TreeFam; TF105391; -.
DR Proteomes; UP000007303; Unassembled WGS sequence.
DR GO; GO:0008305; C:integrin complex; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
DR GO; GO:0007229; P:integrin-mediated signaling pathway; IEA:UniProtKB-KW.
DR Gene3D; 1.20.5.930; Bicelle-embedded integrin alpha(iib) transmembrane segment; 1.
DR Gene3D; 2.130.10.130; Integrin alpha, N-terminal; 1.
DR Gene3D; 2.60.40.1460; Integrin domains. Chain A, domain 2; 1.
DR Gene3D; 2.60.40.1510; ntegrin, alpha v. Chain A, domain 3; 1.
DR Gene3D; 3.40.50.410; von Willebrand factor, type A domain; 1.
DR InterPro; IPR013517; FG-GAP.
DR InterPro; IPR013519; Int_alpha_beta-p.
DR InterPro; IPR000413; Integrin_alpha.
DR InterPro; IPR018184; Integrin_alpha_C_CS.
DR InterPro; IPR013649; Integrin_alpha_Ig-like_1.
DR InterPro; IPR048285; Integrin_alpha_Ig-like_2.
DR InterPro; IPR028994; Integrin_alpha_N.
DR InterPro; IPR032695; Integrin_dom_sf.
DR InterPro; IPR002035; VWF_A.
DR InterPro; IPR036465; vWFA_dom_sf.
DR PANTHER; PTHR23220; INTEGRIN ALPHA; 1.
DR PANTHER; PTHR23220:SF21; INTEGRIN ALPHA-11; 1.
DR Pfam; PF01839; FG-GAP; 2.
DR Pfam; PF08441; Integrin_A_Ig_1; 1.
DR Pfam; PF20805; Integrin_A_Ig_2; 1.
DR Pfam; PF00092; VWA; 1.
DR PRINTS; PR01185; INTEGRINA.
DR PRINTS; PR00453; VWFADOMAIN.
DR SMART; SM00191; Int_alpha; 5.
DR SMART; SM00327; VWA; 1.
DR SUPFAM; SSF69318; Integrin alpha N-terminal domain; 1.
DR SUPFAM; SSF69179; Integrin domains; 2.
DR SUPFAM; SSF53300; vWA-like; 1.
DR PROSITE; PS51470; FG_GAP; 4.
DR PROSITE; PS00242; INTEGRIN_ALPHA; 1.
DR PROSITE; PS50234; VWFA; 1.
PE 3: Inferred from homology;
KW Calcium {ECO:0000256|ARBA:ARBA00022837};
KW Cell adhesion {ECO:0000256|ARBA:ARBA00022889,
KW ECO:0000256|RuleBase:RU003762};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Integrin {ECO:0000256|ARBA:ARBA00023037, ECO:0000256|RuleBase:RU003762};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU003762};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000256|RuleBase:RU003762};
KW Reference proteome {ECO:0000313|Proteomes:UP000007303};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU003762};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU003762}.
FT TRANSMEM 1142..1164
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU003762"
FT REPEAT 21..79
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT DOMAIN 161..343
FT /note="VWFA"
FT /evidence="ECO:0000259|PROSITE:PS50234"
FT REPEAT 465..526
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT REPEAT 528..586
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT REPEAT 591..651
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
SQ SEQUENCE 1192 AA; 128927 MW; B4536DE0222B55FA CRC64;
KDGGKGRLLS WADLLCFNFH TKKVWIFPGS EEARFGSTVQ QHQAGGRQWL LVGAPFQTSG
RKRTGDVFRC PLDNGTSEGC SRLHLGNLSL DSVSQRAEEM RLGLTLTSDP RDSSFVTCGP
LWSHECGSSL YSTGICSRVS RTFRPTGTIA PALQRCETFM DIIIVLDGSN SIYPWSEVQN
FLINILHKFF MGPGQTQVGV VQYGSSVVQE FRLGEHRTVE EVVVAARSIR QRGGEETRTA
LGMEVARSQG FGRGGRPGAR KVMIVITDGE SHDSAQLPQA VARSNRDNIT TYAIAVVLGS
YNRRGMDPEA FLEEIRLIAS DPDQEHCFKV TDESALKDIV DALGERIFSL EAGASPRGRG
FGLQMAQAGF SAHLVKDGVL LGAVGANDWN GAVLKDTKDG KVVPPRSSYE DEFPEELKNH
GAYLGYSVGS LISSDGSQLY TAGAPRFNHT GKVIVFTLAD SGNLTVLKAL LGEQIGSYFG
SQLLSMDVDG DGRSDVLLVA APMYYSQGWE RGKVYVYGVT PELALVLQGA LEASDGAQNA
RLGSSMAAIG DMNGDGFQEL VVGAPLEDDH QGAVYVFYGR GRTIQRRHRQ QRLPAAGFSA
GLRYFGQSVH GVLDVNGDGL VDLAVGALGA AAIIWSRGVV RVQAGLLFQP EKVDVSNKDC
RRGGKAAACM AVTVCLSLSS RTSATATVGA DVWYSLAFDE GRSPPRAVLE EPDQQQLSRL
FLQTGSQSCR HHAFSVQETS DYGHPITVVL ETGLQDPDRG PVLDPDQPSV LRAALPFWNG
CDQEDACVPD LVLHAGTDLL DVGQFCSSGS VWSVCGHRSA AEGGAGVVEA RRRKVAVLAR
LENRGENAYA AALRVSTSSN LLFSGLVLKD QSDVEMECFS ESRAAGELSC NVSAPFLKPS
AQVSFRLEFE LRPALLLDHI QVVMATSSEG RDRNPEDNIC YIFLPLRYQA DLLFTRDPNP
LRFQIQAGGP APFSWSQGGA DSCHDFNLTY QIRNLGTLPV HGLVFRAEIW AVTRGGNQLV
EMLDLGLDQE EEEGRPSGAS SFLPNGPAAE DLSHLSQLNR SNGASVAAQC GLHLPASTQL
EVRLRGRLLC PALLAVGFRA LEVMTTASIR MDASSPAFLQ EDLAVREIIL EIRKEGDYIN
PVWIILGSSL GGLLLLALLV LALWKIGFFR RQRPEEEEEQ PVANGKAAEE LS
//
