ID   H3CE33_TETNG            Unreviewed;       381 AA.
AC   H3CE33;
DT   18-APR-2012, integrated into UniProtKB/TrEMBL.
DT   18-APR-2012, sequence version 1.
DT   27-MAR-2024, entry version 45.
DE   RecName: Full=Deoxyribonuclease-2-alpha {ECO:0000256|ARBA:ARBA00039868};
DE            EC=3.1.22.1 {ECO:0000256|ARBA:ARBA00012036};
DE   AltName: Full=Acid DNase {ECO:0000256|ARBA:ARBA00041393};
DE   AltName: Full=Deoxyribonuclease II alpha {ECO:0000256|ARBA:ARBA00043033};
DE   AltName: Full=Lysosomal DNase II {ECO:0000256|ARBA:ARBA00041918};
OS   Tetraodon nigroviridis (Spotted green pufferfish) (Chelonodon
OS   nigroviridis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Tetraodon.
OX   NCBI_TaxID=99883 {ECO:0000313|Ensembl:ENSTNIP00000006507.1, ECO:0000313|Proteomes:UP000007303};
RN   [1] {ECO:0000313|Proteomes:UP000007303}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15496914; DOI=10.1038/nature03025;
RA   Jaillon O., Aury J.-M., Brunet F., Petit J.-L., Stange-Thomann N.,
RA   Mauceli E., Bouneau L., Fischer C., Ozouf-Costaz C., Bernot A., Nicaud S.,
RA   Jaffe D., Fisher S., Lutfalla G., Dossat C., Segurens B., Dasilva C.,
RA   Salanoubat M., Levy M., Boudet N., Castellano S., Anthouard V., Jubin C.,
RA   Castelli V., Katinka M., Vacherie B., Biemont C., Skalli Z., Cattolico L.,
RA   Poulain J., De Berardinis V., Cruaud C., Duprat S., Brottier P.,
RA   Coutanceau J.-P., Gouzy J., Parra G., Lardier G., Chapple C.,
RA   McKernan K.J., McEwan P., Bosak S., Kellis M., Volff J.-N., Guigo R.,
RA   Zody M.C., Mesirov J., Lindblad-Toh K., Birren B., Nusbaum C., Kahn D.,
RA   Robinson-Rechavi M., Laudet V., Schachter V., Quetier F., Saurin W.,
RA   Scarpelli C., Wincker P., Lander E.S., Weissenbach J., Roest Crollius H.;
RT   "Genome duplication in the teleost fish Tetraodon nigroviridis reveals the
RT   early vertebrate proto-karyotype.";
RL   Nature 431:946-957(2004).
RN   [2] {ECO:0000313|Ensembl:ENSTNIP00000006507.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=Endonucleolytic cleavage to nucleoside 3'-phosphates and 3'-
CC         phosphooligonucleotide end-products.; EC=3.1.22.1;
CC         Evidence={ECO:0000256|ARBA:ARBA00000447};
CC   -!- SIMILARITY: Belongs to the DNase II family.
CC       {ECO:0000256|ARBA:ARBA00007527}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   AlphaFoldDB; H3CE33; -.
DR   STRING; 99883.ENSTNIP00000006507; -.
DR   Ensembl; ENSTNIT00000006657.1; ENSTNIP00000006507.1; ENSTNIG00000003900.1.
DR   GeneTree; ENSGT00390000002634; -.
DR   HOGENOM; CLU_053867_0_1_1; -.
DR   InParanoid; H3CE33; -.
DR   OMA; EGPWACV; -.
DR   TreeFam; TF314536; -.
DR   Proteomes; UP000007303; Unassembled WGS sequence.
DR   GO; GO:0004531; F:deoxyribonuclease II activity; IEA:UniProtKB-EC.
DR   CDD; cd09189; PLDc_DNaseII_alpha_1; 1.
DR   CDD; cd09191; PLDc_DNaseII_alpha_2; 1.
DR   InterPro; IPR004947; DNase_II.
DR   PANTHER; PTHR10858; DEOXYRIBONUCLEASE II; 1.
DR   PANTHER; PTHR10858:SF9; DEOXYRIBONUCLEASE-2-ALPHA; 1.
DR   Pfam; PF03265; DNase_II; 1.
PE   3: Inferred from homology;
KW   Developmental protein {ECO:0000256|ARBA:ARBA00022473};
KW   Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW   Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW   Nuclease {ECO:0000256|ARBA:ARBA00022722};
KW   Reference proteome {ECO:0000313|Proteomes:UP000007303};
KW   Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP}.
FT   SIGNAL          1..16
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           17..381
FT                   /note="Deoxyribonuclease-2-alpha"
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5003581196"
SQ   SEQUENCE   381 AA;  41847 MW;  09037A02EACDE213 CRC64;
     MLLFLLVFAL PVEVNSSPIS CYNDQGAAVD WFYLYKLPKE DRMEPQEEGD RYLLLEKGSE
     EWSNGQGTVN DTTGALGRTV GQLYSQGKNT ERAYILYNDQ KPTVDLTDRR VHMSGSSRGH
     TKGVVLLDKH QGFWLVHSTP HFPPAQKEGQ YYYPGSGLIN GQNFICVTYP LERFQTIDTG
     EQLQINQPSV YDCDVPQSLA SLVPALAAVC GGKATYGRAS PQIQRVANRS VTLTSAGGTN
     FISFAKGASF KNDLYHAWVA PALQSDLLVQ FWVRSTGVLP SDCSLGWKVL DVTRINPGKT
     SEFKASQDHS KWAVSTKAAG SGAGGGWVCV GDINRNMAEE KRGGGTVCLR DPVVWKAYRT
     AVVDYEDCGR DKKSPICVLQ L
//