ID H3CF81_TETNG Unreviewed; 681 AA.
AC H3CF81;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 1.
DT 27-MAR-2024, entry version 67.
DE SubName: Full=Sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3H {ECO:0000313|Ensembl:ENSTNIP00000006905.1};
OS Tetraodon nigroviridis (Spotted green pufferfish) (Chelonodon
OS nigroviridis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Tetraodon.
OX NCBI_TaxID=99883 {ECO:0000313|Ensembl:ENSTNIP00000006905.1, ECO:0000313|Proteomes:UP000007303};
RN [1] {ECO:0000313|Proteomes:UP000007303}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15496914; DOI=10.1038/nature03025;
RA Jaillon O., Aury J.-M., Brunet F., Petit J.-L., Stange-Thomann N.,
RA Mauceli E., Bouneau L., Fischer C., Ozouf-Costaz C., Bernot A., Nicaud S.,
RA Jaffe D., Fisher S., Lutfalla G., Dossat C., Segurens B., Dasilva C.,
RA Salanoubat M., Levy M., Boudet N., Castellano S., Anthouard V., Jubin C.,
RA Castelli V., Katinka M., Vacherie B., Biemont C., Skalli Z., Cattolico L.,
RA Poulain J., De Berardinis V., Cruaud C., Duprat S., Brottier P.,
RA Coutanceau J.-P., Gouzy J., Parra G., Lardier G., Chapple C.,
RA McKernan K.J., McEwan P., Bosak S., Kellis M., Volff J.-N., Guigo R.,
RA Zody M.C., Mesirov J., Lindblad-Toh K., Birren B., Nusbaum C., Kahn D.,
RA Robinson-Rechavi M., Laudet V., Schachter V., Quetier F., Saurin W.,
RA Scarpelli C., Wincker P., Lander E.S., Weissenbach J., Roest Crollius H.;
RT "Genome duplication in the teleost fish Tetraodon nigroviridis reveals the
RT early vertebrate proto-karyotype.";
RL Nature 431:946-957(2004).
RN [2] {ECO:0000313|Ensembl:ENSTNIP00000006905.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the semaphorin family.
CC {ECO:0000256|ARBA:ARBA00009492}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00352}.
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DR AlphaFoldDB; H3CF81; -.
DR STRING; 99883.ENSTNIP00000006905; -.
DR Ensembl; ENSTNIT00000007057.1; ENSTNIP00000006905.1; ENSTNIG00000004276.1.
DR GeneTree; ENSGT00940000166389; -.
DR HOGENOM; CLU_009051_5_0_1; -.
DR InParanoid; H3CF81; -.
DR OMA; MCWLLTA; -.
DR TreeFam; TF352628; -.
DR Proteomes; UP000007303; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0030215; F:semaphorin receptor binding; IEA:InterPro.
DR GO; GO:0007411; P:axon guidance; IEA:UniProt.
DR CDD; cd05871; Ig_Sema3; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR Gene3D; 3.30.1680.10; ligand-binding face of the semaphorins, domain 2; 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR016201; PSI.
DR InterPro; IPR001627; Semap_dom.
DR InterPro; IPR036352; Semap_dom_sf.
DR InterPro; IPR027231; Semaphorin.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR PANTHER; PTHR11036:SF21; SEMA3H PROTEIN; 1.
DR PANTHER; PTHR11036; SEMAPHORIN; 1.
DR Pfam; PF01403; Sema; 1.
DR SMART; SM00409; IG; 1.
DR SMART; SM00423; PSI; 1.
DR SMART; SM00630; Sema; 1.
DR SUPFAM; SSF48726; Immunoglobulin; 1.
DR SUPFAM; SSF103575; Plexin repeat; 1.
DR SUPFAM; SSF101912; Sema domain; 1.
DR PROSITE; PS50835; IG_LIKE; 1.
DR PROSITE; PS51004; SEMA; 1.
PE 3: Inferred from homology;
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00022989};
KW Reference proteome {ECO:0000313|Proteomes:UP000007303};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022989};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989}.
FT DOMAIN 1..481
FT /note="Sema"
FT /evidence="ECO:0000259|PROSITE:PS51004"
FT DOMAIN 530..632
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
SQ SEQUENCE 681 AA; 76843 MW; 0A3A45707EB1A17B CRC64;
HVQHTELIQN GRLLTLPLAA GDLHSLLPDE DGRHLYVAMK DNLLSTSLDD ITQNPRKLYW
PASPDRVQEC LMAGKDPELE CANFLRVLQH FNQTHLYVCG TGAFNPRCAF VPTSVFRKSE
HQMLSYSQTE CGKGKCPYDP FQKTASTVVD GELYAGITSD FMSRDSSFFR SLGSRRVIRT
EQYDSTWLLD AQFVRVAPLS ETDNPEDDKV YMFFTERAQE AEGAAGKILY SRVARVCKND
IGGQRSLVNK WSTFQKARLV CSVPGPDGLH THFDQLQDIF ILHGKDKKNP LIYGLFTTSS
DILNGSAVCV YRMEDVVRAF KGNFLHKEGP QYKWAEFTGK VPYPRPGTCP SSTYGSYSST
REYPDDVIFF SRTHPLLQES VLPLGERPLL VRVGVHYKFS KLVVDRVEAV DSTYDVLFIG
TDSGLVLKAI HLPKDHGQSQ EITLEQMQVF QHKSPVTAMT LSKKKQWLFV GSREGVSQLS
LYQCELYGQA CAECCLARDP YCTWDGHACS PYMPTVRRRN ARHLGEDEDP LTQCVRQGAG
LQVEAEQRVM MVAEGNSTYL ECLPRSRHAA VTWYKQAGEN SPELNQVVTG DQLVVIERGI
LIRQAELSHG GVYHCQVEEH GYHWTAVTVR LTVWSPFADR LLSPWSGSLY HSTGTQRWYE
DVMALIHPGN IGQHCQALGY R
//
