ID H3CFJ3_TETNG Unreviewed; 649 AA.
AC H3CFJ3;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 1.
DT 27-MAR-2024, entry version 67.
DE RecName: Full=SAM domain-containing protein {ECO:0000259|PROSITE:PS50105};
OS Tetraodon nigroviridis (Spotted green pufferfish) (Chelonodon
OS nigroviridis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Tetraodon.
OX NCBI_TaxID=99883 {ECO:0000313|Ensembl:ENSTNIP00000007020.1, ECO:0000313|Proteomes:UP000007303};
RN [1] {ECO:0000313|Proteomes:UP000007303}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15496914; DOI=10.1038/nature03025;
RA Jaillon O., Aury J.-M., Brunet F., Petit J.-L., Stange-Thomann N.,
RA Mauceli E., Bouneau L., Fischer C., Ozouf-Costaz C., Bernot A., Nicaud S.,
RA Jaffe D., Fisher S., Lutfalla G., Dossat C., Segurens B., Dasilva C.,
RA Salanoubat M., Levy M., Boudet N., Castellano S., Anthouard V., Jubin C.,
RA Castelli V., Katinka M., Vacherie B., Biemont C., Skalli Z., Cattolico L.,
RA Poulain J., De Berardinis V., Cruaud C., Duprat S., Brottier P.,
RA Coutanceau J.-P., Gouzy J., Parra G., Lardier G., Chapple C.,
RA McKernan K.J., McEwan P., Bosak S., Kellis M., Volff J.-N., Guigo R.,
RA Zody M.C., Mesirov J., Lindblad-Toh K., Birren B., Nusbaum C., Kahn D.,
RA Robinson-Rechavi M., Laudet V., Schachter V., Quetier F., Saurin W.,
RA Scarpelli C., Wincker P., Lander E.S., Weissenbach J., Roest Crollius H.;
RT "Genome duplication in the teleost fish Tetraodon nigroviridis reveals the
RT early vertebrate proto-karyotype.";
RL Nature 431:946-957(2004).
RN [2] {ECO:0000313|Ensembl:ENSTNIP00000007020.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR AlphaFoldDB; H3CFJ3; -.
DR STRING; 99883.ENSTNIP00000007020; -.
DR Ensembl; ENSTNIT00000007176.1; ENSTNIP00000007020.1; ENSTNIG00000004386.1.
DR GeneTree; ENSGT00940000158264; -.
DR HOGENOM; CLU_004064_0_1_1; -.
DR InParanoid; H3CFJ3; -.
DR OMA; ETVQHWS; -.
DR TreeFam; TF316498; -.
DR Proteomes; UP000007303; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0006325; P:chromatin organization; IEA:UniProtKB-KW.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR CDD; cd20101; MBT_L3MBTL1-like_rpt1; 1.
DR CDD; cd09582; SAM_Scm-like-3MBT3_4; 1.
DR Gene3D; 2.30.30.140; -; 3.
DR Gene3D; 4.10.320.30; -; 1.
DR Gene3D; 1.10.150.50; Transcription Factor, Ets-1; 1.
DR InterPro; IPR004092; Mbt.
DR InterPro; IPR001660; SAM.
DR InterPro; IPR013761; SAM/pointed_sf.
DR InterPro; IPR002515; Znf_C2H2C.
DR PANTHER; PTHR12247:SF78; LETHAL(3)MALIGNANT BRAIN TUMOR-LIKE PROTEIN 4; 1.
DR PANTHER; PTHR12247; POLYCOMB GROUP PROTEIN; 1.
DR Pfam; PF02820; MBT; 3.
DR Pfam; PF00536; SAM_1; 1.
DR Pfam; PF01530; zf-C2HC; 1.
DR SMART; SM00561; MBT; 3.
DR SMART; SM00454; SAM; 1.
DR SUPFAM; SSF47769; SAM/Pointed domain; 1.
DR SUPFAM; SSF63748; Tudor/PWWP/MBT; 3.
DR PROSITE; PS51079; MBT; 3.
DR PROSITE; PS50105; SAM_DOMAIN; 1.
DR PROSITE; PS51802; ZF_CCHHC; 1.
PE 4: Predicted;
KW Chromatin regulator {ECO:0000256|ARBA:ARBA00022853};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000007303};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU01143}.
FT REPEAT 4..104
FT /note="MBT"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00459"
FT REPEAT 113..211
FT /note="MBT"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00459"
FT REPEAT 220..314
FT /note="MBT"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00459"
FT DOMAIN 577..641
FT /note="SAM"
FT /evidence="ECO:0000259|PROSITE:PS50105"
FT REGION 434..525
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 435..464
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 480..494
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 649 AA; 72362 MW; 07F9D45BFBE04F2B CRC64;
RRSWSWQQYL NEQKAEAAPV SLFTQSQSFP SRKTGFKVGM KLEGIDPLHP SMFCVLTVAE
VIGCRLRLHI DGFSECYDFW VNSDSAEIRP AGWCKDNKRK LHPPKAGQNQ SDFDWTAYLD
SCGSRAAPSS LFTSHRASQS CDFQVGMKLE AVDKKNPGLV CVASVTDVVD GRFLVHFDNW
DDTYDYWCDS SSPYIHPVGW CEEQGRPLTS PQGHPNPENF LWEEYLQETG SVAAPSSAFQ
PRRLHRFQVH HKLEAVDRRN PLIRVATVTE TDDCRVKVHY DGWSQQFDVW CDGDNSDLHP
VGWCQRTEHP LEPPPGSSPV SSPSQGVCPT PGCRGVGHIK GARYTGHHRQ SFGCPYSDIN
TRKEVVLPDR LGGERVITLV PVSVCSHGNQ PDRYLSSGLG SEPDWRRLGG GFGVETRSCS
RRVVDPAGVV LHPHLPVSRR DRTGVQVKSE DRREPLEEKS GGQVRRPSAR AGPAQPLPVV
SDAVSSSRQP LTVAAQQVPP RERGRGGAAG HGRQSRYSGW EQQLSPTESS LQAALHQSIF
LSAMSAQPGR DLSLCWEQHR KLLPGVVRET AETVQHWSVQ QVADFVESLP GCEEQSKQFR
DEQIDGRAFL LLTQRDIVRI MSIKLGPALK IYNSILMFKH AKSRSQSPA
//
