ID H3CFQ5_TETNG Unreviewed; 4906 AA.
AC H3CFQ5;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 1.
DT 27-MAR-2024, entry version 69.
DE RecName: Full=Titin {ECO:0008006|Google:ProtNLM};
OS Tetraodon nigroviridis (Spotted green pufferfish) (Chelonodon
OS nigroviridis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Tetraodon.
OX NCBI_TaxID=99883 {ECO:0000313|Ensembl:ENSTNIP00000007082.1, ECO:0000313|Proteomes:UP000007303};
RN [1] {ECO:0000313|Proteomes:UP000007303}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15496914; DOI=10.1038/nature03025;
RA Jaillon O., Aury J.-M., Brunet F., Petit J.-L., Stange-Thomann N.,
RA Mauceli E., Bouneau L., Fischer C., Ozouf-Costaz C., Bernot A., Nicaud S.,
RA Jaffe D., Fisher S., Lutfalla G., Dossat C., Segurens B., Dasilva C.,
RA Salanoubat M., Levy M., Boudet N., Castellano S., Anthouard V., Jubin C.,
RA Castelli V., Katinka M., Vacherie B., Biemont C., Skalli Z., Cattolico L.,
RA Poulain J., De Berardinis V., Cruaud C., Duprat S., Brottier P.,
RA Coutanceau J.-P., Gouzy J., Parra G., Lardier G., Chapple C.,
RA McKernan K.J., McEwan P., Bosak S., Kellis M., Volff J.-N., Guigo R.,
RA Zody M.C., Mesirov J., Lindblad-Toh K., Birren B., Nusbaum C., Kahn D.,
RA Robinson-Rechavi M., Laudet V., Schachter V., Quetier F., Saurin W.,
RA Scarpelli C., Wincker P., Lander E.S., Weissenbach J., Roest Crollius H.;
RT "Genome duplication in the teleost fish Tetraodon nigroviridis reveals the
RT early vertebrate proto-karyotype.";
RL Nature 431:946-957(2004).
RN [2] {ECO:0000313|Ensembl:ENSTNIP00000007082.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR STRING; 99883.ENSTNIP00000007082; -.
DR Ensembl; ENSTNIT00000007239.1; ENSTNIP00000007082.1; ENSTNIG00000004444.1.
DR GeneTree; ENSGT01100000263523; -.
DR HOGENOM; CLU_223047_0_0_1; -.
DR InParanoid; H3CFQ5; -.
DR OMA; KKPRNDG; -.
DR Proteomes; UP000007303; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR CDD; cd00063; FN3; 35.
DR CDD; cd05748; Ig_Titin_like; 4.
DR Gene3D; 2.60.40.10; Immunoglobulins; 50.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR013098; Ig_I-set.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR PANTHER; PTHR14340:SF24; -; 1.
DR PANTHER; PTHR14340; MICROFIBRIL-ASSOCIATED GLYCOPROTEIN 3; 1.
DR Pfam; PF00041; fn3; 34.
DR Pfam; PF07679; I-set; 14.
DR PRINTS; PR00014; FNTYPEIII.
DR SMART; SM00060; FN3; 35.
DR SMART; SM00409; IG; 14.
DR SMART; SM00408; IGc2; 13.
DR SUPFAM; SSF49265; Fibronectin type III; 20.
DR SUPFAM; SSF48726; Immunoglobulin; 14.
DR PROSITE; PS50853; FN3; 35.
DR PROSITE; PS50835; IG_LIKE; 8.
PE 4: Predicted;
KW Immunoglobulin domain {ECO:0000256|ARBA:ARBA00023319};
KW Membrane {ECO:0000256|ARBA:ARBA00022989};
KW Reference proteome {ECO:0000313|Proteomes:UP000007303};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022989};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989}.
FT DOMAIN 1..34
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 40..135
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 135..206
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 231..326
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 328..421
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 524..617
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 623..718
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 721..817
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 821..912
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 919..1015
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1021..1116
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1122..1218
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1321..1416
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1418..1515
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1513..1600
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 1612..1705
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1711..1808
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1809..1906
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1908..1998
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 2006..2099
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 2163..2263
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 2262..2347
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 2358..2453
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 2455..2548
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 2650..2744
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 2750..2844
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 2848..2947
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 3051..3144
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 3150..3246
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 3323..3410
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 3420..3514
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 3517..3611
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 3715..3808
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 3814..3910
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 3917..4013
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 4016..4105
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 4112..4209
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 4213..4308
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 4314..4409
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 4512..4608
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 4614..4712
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 4718..4810
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 4815..4906
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
SQ SEQUENCE 4906 AA; 544657 MW; E4527020F9C098F1 CRC64;
LRKGCEYDFR VYAENEAGLS PPSEPSAVFR AADPVVVPSR PPKPKIISST KNSVSLVWKS
PTDDGGAPIL GYTVEYREHI LKPEPEFLEE EDYEVIGLKT NQEYEFCVKA INKVGSSARS
PYSDSATAVD RTVEPSFDVG IEMRKVLMVK HGTAFTLNLP FKGKPVPSVT WDKEGIDLKL
RGTIDTTESS TSLTIEKSCR NDSGEYCVTL ESPLGKATLP MIVKVLDTPG PPVNVKVSAV
TRDSATLTWE APENDGGDAV KAYHVEKREA SKKAWVSVTS NCHVFTYKVE DLQEGAIYYF
RVIGENEYGL GVPQEAKAGT KITEVPTPPM KLGVLNVTKD SITIAWTRPE YDGGSRVTGY
FIEALEKGQT KWIKCATVKT MTHTIKNLRE AAEYFFRVQA ENHAGLSEPK EMIVPVIVKE
IQDAPEFDLK NYPKNTVYVR AGSDLTFEIP LRGRPMPKVS LSKNNIVIKG SKRLLTEVTP
DSLLVTLNES ISSDAGKYEI TASNAGGTTK TFIIVLVLDR PGPPVGPVEI GEVGETTACL
KWAPPGYDGG SPVTNYIVLK RETSTPTWTE VATSIARSSF KVTKLTKGEE YQFRIKAQNR
YGVSDHIDSK PVLIRLPYTI PGPPSTPWLG FVSRESLTVC WNEPVNDGGN PVIGYHLHMK
ERSSLIWQKV NKTPISGNLW RVTNICPGLI YEFKVAAENA AGVGKMSKTS EEVLAIDACE
PPAHVHVTEV SKNSVSLAWQ RPPYDGGSKI TGYSVERRET PSGRWVKANF TNIIELGFTV
SGLSQDESYE FRVFARNAVG SISNPSLIAG PVTCIEACGS PAIDLPPEYL DVVQYKAGAS
VKLKVGITAK PLPMIEWLKD GKELVATSTI SVENTTDTSA VLIKDAARHH TGSYEIKIRN
VLGSASAIIK IEILDKPGPP AGTINFNSIT ADKIIFSWNP VPESDQGGAK VTHYVVERRE
TSRVVWSTIS DMQEKPPITV VKLVGGNEYV FRVMAVNKFG IGEPLESEPV IAKNSFVTPG
QPHTPEVNTI TKSTMVVEWA KPVVDGGSAV TGYYLERRDK KSLRWIRVYK DPVTVTKQAI
CHLTEGNEYQ YRVCAINKAG EGPFSEASDY YKAADPVDPP DEPCKLKVVD STKTSITLSW
SKPEWDGGSD VTSYMVEKLV EGEQEWAPIT SKGEVRTTEY TVHDLKPDAN YFFRVSAVNS
AGRGEPLEMT ESVQAKDILE EAQIDSDVAM RTHYIVKAGN DVELSVPLKG RPCPTVSWYK
GEECIDCDPK YEFHHSDTIT VLVMREVTRL DTGKYTVKIE NGVGEPKKLT LSVKVLDTPS
QCKNLVIRDV SRGKVTLCWE PPLFDGGAEI TNYIVEKRDS SKRSYSAVTT KCISTTYTIE
DLSEKTSFFF RVLAENENGI GDSCEILEPV KATETPGSVK EVSMKDSSKT SVTLQWLKPS
YDGGSIISDY IIEKKLKDEE WSLGGTSRQC EFEVKKLKEH SEVFFRVAAR NEKGQGEFVA
IGPIKVIDYI ITPEANLSEY PDGTLSIRLG HNVHIELPYK GKPKPSMLWL KDNLPLKESE
QIRFKKTENK ATLMIKNVRK ENEGKYTLTL DNKVNRRSFH IHVITLGPPS KPVGPIRLDE
VRADSIMISW DEPNDDGGGD ITCYTVEKRD TSQSNWKMAC SHVQDTQFKV LNLIKGVQYQ
FKVYAENRYG VSEPLISQMV IAKHQFRPPG PPGKPVVYNV TSDGMTIQWE KPIYDGGTPI
QGFHVEKKEM NSIMWQKVNT MLIKETEYRI LGLIEGLEYS FRVYAQNDAG FSRIGDESKP
TMAVSPVDAP GQPDYIDVTS DSVTLKWDAP KRDGGSKITG YNIEKRQGQG RWFKANLTDV
HDCQYTITGL ATNERYEFRV IARNAIGVVS PPSNSSGLIV VRSENASPNI EFGPEYFEGL
TVKAGDNIRL KVTITGRPVP KVVWYKNGIE ITKRIMDIIN ITGSSTLFVR DADRTYSGLY
TVEATNSSGF KKENILVQVQ DTPGEPLGPI TFSNISEGKI TLSWRPPEND GCSEISHFII
EKRETSKISW ALVSDECKQC TFNATKLIKT NEYQFRVSAV NIFGVGRALE STPIIAQLQY
SRLKLFICSK ETNLTKMPHK VLHLTEDMEY EFRVMAVNDA GVSAPSNVSL PIKAAEPKDI
PCAPSVVCVS DSTNNSITLE WTKPADDGGM EILGYIIEMV KGEETEWMRI NGQLVVETNY
MVTGLETGAE YKFRVAAVNY VGRGEDTETT EPAQAVDRLT PPQLDIDASF KQTHIVKAGG
SVCLDIHFRG KPIPTATWVK EEGELGVMSE ITTADGYSSL NIENCSRNDT GKYTVNLENS
SGSKAVTFTV KIMDTPGPPQ TVIFKEVSRG TVTLTWEPPV NDGGARIHHY IVERREASRR
TWQQSGGKCT QNILKIKDLL EGVPYFFRVS AENQHGVGEA FEVPESVIAT AEPAVPKRLD
ILDTTDTSVF LGWTKPEHDG GSRIKCYIIE AKAKGTDKWV VMGNTKNLFY VVEKLNKGHE
YHFRVIAKNE SGLSSPQETV VPVLVKEPHI EPTADLSEID GQLIMSRSGS TFTIDVPISG
RPAPKITWKL EEMRLKNTDR VSIKEAQNRT SISVKEAMRG DSGKYNLILE NAAGTKTFVV
DVNVIGKPSP PTGPIEISSI TAESCILNWH PPEDDGGTDI TNYIVEKRES GSTAWQLINS
SVKRTSLFVS HLTKYMQYTF RVSAENNFGV SKATESETIV AEHPFTPPGP PTRPSVFNIT
ANTMTLKWEE PYHDGGSKVT GYWIEKKERN NILWVRENKI PCFECNYRAE SLVEGLEYQF
RVYAMNSAGL SKASEASKGA VAQNPVDPPT KPEVTNVTRT TVSLKWSAPL NDGGSPIVGY
IIERKPYTLT GEGRWLKCNY TNVTDTFYTV TALGEGEPYE FRVIAKNANQ VCSIPSESTG
SVQCKTDFEP PKAQLDSKLM SETVMVRAGS DLVLDAAVGG RPEPKAFWSK GNRELDLCEK
YHLQYSPTRA MAVIKFCDRD DTGKYILTVK NVSGTKTAEV SVKVLDTPGV CEGSITISKV
TEESCTLSWK PPVEDGGDDV SHYIVERRDT NRLNWVIVHA ECKELNCNIT RLFKNTEYLF
RVRGVNKYGP GVYLQSEPMV ARNTFTVPSP PGSPEIVASG KDFATIEWMK PESDGGSPLI
HYLVERREKK SARWWKKAHE KTLRGTEYVV IGLSAATKYY FRVAGVNING TGEFSEPCAA
AEPVERIGHP LLEKNIIKIF PSRKAVTIIS YPNPNSVQIN GYNFTHCLKK TNRSNLKHNF
KICHIINCKI INHTILYFCV ETPDVELADD LKKTICLRAG GSLRLSVKVT GRPVPAITWS
KSETDLHNRG FIEVTNTSTT LIIDKVHRYD AGKYTVVAEN SAGKQEANIL VKVYADTPGP
TRPIKIKELT KESVTISWEA PAIDGGAPVN NYIIERREAS MRAYKTVTSK CSKTTFKIDG
LMEGMLYYFR VLPENIYGIG EPRETPDAIL VCEVPLSPHK LEVIDVTKTT VTLGWEKPEH
DGGSRLTGYI IEACKFGTDR WMKVATLKTT DFEHTIEKLN ESEQYLFRIR AINSRGASEP
KELVTAVTVQ EQRVMPEVDF SAIPQKVINV LAGKTLELDL PIVGRPPPVC SWYFRENRIK
ITDRIHFKST GKFSKLVIHD TNIDDTGDYT LEVTNAVGLI SEVIKVIILS KPDEPKGPLR
FDEIDATTVT CSWDPPIRDG GAPISGFVVE QRDAHRPGWV TVCESVSRPT FKFENLIEGD
EYVFRAAATN RYGTGEFLQS EIVTCKSLTN VPGPPGRPTV FDISRDGMTV AWNPPEEDGG
LEVSGYIIER KEVRSDRWVR ANKNPITMTR YRSTELIEGL EYEHRVTALN AKGLSKPSLP
SKPAVATDPI EIDPPGCPQN PRITDTTKTS VSLAWSPPDD EGDARVDGYL IEMQKVGTTA
WIKCNTTPSL ICEYTLTNMP QGEEFKFRVM ACNAGGSGEP AEVPGTVTVT EMLESPDFDL
EPKYKDLYTV RQGGVVRLSV PIRGKPQPTC KWSKDFGALS TNAMIVSTED VSELVIKGAE
RSDSGLYDLL LENRVGKKKA QIKVKVIGRP SAPEGPLVFD DIHANSVKVS WKVPIDNGGS
EILGYILERR EATRNAWYTV ESRITETQVV VKGLKEGTEY HFKVTAENSF GFSSSLKSEH
PVVPKTPLCS PEPPSTPPEI MDITKNSVAL AWSRPKDDGG SAVTGYFVEY RIVSSDTWSR
HETQITSTMF TLSGLTPDSE YQFRIFAVNS IGESEAGPVS DSVTCKDPFD KPSQPGEIDI
VQVTNNSVAI RWQAPECDGG KEVLGYWVEC RKSIESTWKK CNKQRLKEKD FTVAGLAEAT
EYEFRVLAEN ETGISRPRRT ATCIKTKLSE AAPSFHPDYP LKDTYCTGLG TTLRIHVVYI
GRPQPKIMWL HGAKTLENTE DITIETTEHY THLIIKNVQR RVHGGKYRIR LHNHFGRADT
AFNVEIYDKP DRPRGPIILD ALLKNSVIIS WKPPTDDGGC MITNYIVEKH EDKEGGEWEL
VSSSINGTSC RVPNLTDSAG YFFRVYAQNR YGNSEPLELT SPILIKSQLE KPSPPLCPIV
SGITKDSCVV SWKPPISDGG SKIKSYCLEM KYKDKREWSE WTPVTTDEIK QTVFSVKCLT
EGVEYVFRVK CENLGGQSDY SEETLSIHPA AAIEIRAPAF KEELRNMSVK YKSNAALVCK
ITGQPKPVVK WLRRGKEIHS DGKKIKIQEF KSFTSLVFPS GVEKKDAGFY IVCAKNRFGI
DQQTVELDVA DVPDPPRGVK ASDISRDSVT LNWVAPANDG GSRVISYIIE KCPTTAERWQ
RVAQSRDTHY TVINLFGGTS YQFRVIAENK FGQSAPSETS GPVMTK
//
