ID H3CFU3_TETNG Unreviewed; 1030 AA.
AC H3CFU3;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 1.
DT 27-MAR-2024, entry version 65.
DE SubName: Full=Platelet endothelial aggregation receptor 1 {ECO:0000313|Ensembl:ENSTNIP00000007120.1};
OS Tetraodon nigroviridis (Spotted green pufferfish) (Chelonodon
OS nigroviridis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Tetraodon.
OX NCBI_TaxID=99883 {ECO:0000313|Ensembl:ENSTNIP00000007120.1, ECO:0000313|Proteomes:UP000007303};
RN [1] {ECO:0000313|Proteomes:UP000007303}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15496914; DOI=10.1038/nature03025;
RA Jaillon O., Aury J.-M., Brunet F., Petit J.-L., Stange-Thomann N.,
RA Mauceli E., Bouneau L., Fischer C., Ozouf-Costaz C., Bernot A., Nicaud S.,
RA Jaffe D., Fisher S., Lutfalla G., Dossat C., Segurens B., Dasilva C.,
RA Salanoubat M., Levy M., Boudet N., Castellano S., Anthouard V., Jubin C.,
RA Castelli V., Katinka M., Vacherie B., Biemont C., Skalli Z., Cattolico L.,
RA Poulain J., De Berardinis V., Cruaud C., Duprat S., Brottier P.,
RA Coutanceau J.-P., Gouzy J., Parra G., Lardier G., Chapple C.,
RA McKernan K.J., McEwan P., Bosak S., Kellis M., Volff J.-N., Guigo R.,
RA Zody M.C., Mesirov J., Lindblad-Toh K., Birren B., Nusbaum C., Kahn D.,
RA Robinson-Rechavi M., Laudet V., Schachter V., Quetier F., Saurin W.,
RA Scarpelli C., Wincker P., Lander E.S., Weissenbach J., Roest Crollius H.;
RT "Genome duplication in the teleost fish Tetraodon nigroviridis reveals the
RT early vertebrate proto-karyotype.";
RL Nature 431:946-957(2004).
RN [2] {ECO:0000313|Ensembl:ENSTNIP00000007120.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR AlphaFoldDB; H3CFU3; -.
DR STRING; 99883.ENSTNIP00000007120; -.
DR Ensembl; ENSTNIT00000007277.1; ENSTNIP00000007120.1; ENSTNIG00000004475.1.
DR GeneTree; ENSGT00940000155333; -.
DR HOGENOM; CLU_008281_1_0_1; -.
DR InParanoid; H3CFU3; -.
DR OMA; VCHNGAK; -.
DR TreeFam; TF332598; -.
DR Proteomes; UP000007303; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0048856; P:anatomical structure development; IEA:UniProt.
DR Gene3D; 2.170.300.10; Tie2 ligand-binding domain superfamily; 4.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR013111; EGF_extracell.
DR InterPro; IPR011489; EMI_domain.
DR InterPro; IPR002049; LE_dom.
DR PANTHER; PTHR24035; MULTIPLE EPIDERMAL GROWTH FACTOR-LIKE DOMAINS PROTEIN; 1.
DR PANTHER; PTHR24035:SF114; PLATELET ENDOTHELIAL AGGREGATION RECEPTOR 1; 1.
DR Pfam; PF07974; EGF_2; 1.
DR Pfam; PF00053; Laminin_EGF; 2.
DR PRINTS; PR00011; EGFLAMININ.
DR SMART; SM00181; EGF; 14.
DR SMART; SM00180; EGF_Lam; 11.
DR PROSITE; PS00022; EGF_1; 9.
DR PROSITE; PS01186; EGF_2; 2.
DR PROSITE; PS50026; EGF_3; 6.
DR PROSITE; PS51041; EMI; 1.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; EGF-like domain {ECO:0000256|PROSITE-ProRule:PRU00076};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000007303};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..18
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 19..1030
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5003582253"
FT TRANSMEM 748..771
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 23..100
FT /note="EMI"
FT /evidence="ECO:0000259|PROSITE:PS51041"
FT DOMAIN 137..172
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 227..252
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 265..295
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 303..338
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 397..427
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 478..513
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT REGION 994..1030
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 162..171
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 242..251
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 285..294
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 328..337
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 417..426
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 503..512
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
SQ SEQUENCE 1030 AA; 112007 MW; 65E0B1906B92EC0A CRC64;
ISLNVLLLLT FLISLSDCLD PTASNVCSIW ESFTTSVKES YSHPYDHVTE EVCSDPQTVY
RCLHHRISYK TAYRQAVKIE YRKRYQCCPG YYESKNKCVP RCTMECVHGR CIAPDRCQCE
RGWRGDDCSS DCDDNHWGPT CSQSCKCKNR ALCDPVKGTC QCSPGFIGRR CEDLCPAGTF
GKDCLQRCKC GNGGSCDKVT GECSCQEGFT GTFCKITCSK KCPARCPCQN GGICKGKGIC
TCPPGWTGAV CTEQCPEGRF GPNCAQECVC HNRGKCDAKT GQCQCAKGFT GSRCNEECAA
GTFGQDCKGV CDCANGARCY NIDGGCLCEP GFHGPHCRDR MCALGKYGMH CENTCLCQDK
NTLSCHPMKG ECTCQPGWAG LFCNETCPHG FYGHGCLEPC LCVNGGVCDS SIGQCQCAPG
FTGVHCENPC KSGTYGKNCS SECSCDNYID CSPVDGTCFC KDGWQGSRCS TPCFEGTWGP
GCNSTCLCTN GAKCNPTDGS CTCTAGWHGT HCDLTCPMGT FGPGCLKKCD CVHADDCHAA
TGVCHCLPGW WGPSCSQPCS VGLWGRHCNK TCQHCLNSDT CLRETGACVC RPGFWGVTCQ
NKCRAGTYGE QCSMPCPSCG QSYRCHHVTG ECDCLPGHTG SNCDQDCPAG YYGKLCSEAC
DNCANNSTCN PRDGHCECLP GWTSSDCSMR EVNRVFPTLA QNYWVCHTGP GLNPKSIGCS
FSPFLKSESS EQSGSVMVPL PPGEKESWGA ISGTVVLVIL VVLLLALLLL YRHRQRDKQN
NTPTVSFSTR GTVNSEYAVP DVPLSYHRYY SNPSYHTLSQ NRPPLPHIPN NHDYTIKTGK
HNRVSEKPQL WHFRSNTLPT SIYDTLCENR CSCHSMQMSA AKNSLANSCS RCYPSWAIPL
LYRKQITIQD LKDTPAISSS SLNSENPYAT IKDLPGLLFC PPESSYMEMK SAVPRDGPHT
GFGQSLSKNS TLHSSFFSSY FVLTGCQTAA GHATHEDPQN HYDLPVNSHI PGHYDLPPIR
QQPSASKTAQ
//
