ID H3CG65_TETNG Unreviewed; 680 AA.
AC H3CG65;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 1.
DT 27-MAR-2024, entry version 45.
DE RecName: Full=Nicastrin {ECO:0000256|ARBA:ARBA00015303};
GN Name=NCSTN {ECO:0000313|Ensembl:ENSTNIP00000007242.1};
OS Tetraodon nigroviridis (Spotted green pufferfish) (Chelonodon
OS nigroviridis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Tetraodon.
OX NCBI_TaxID=99883 {ECO:0000313|Ensembl:ENSTNIP00000007242.1, ECO:0000313|Proteomes:UP000007303};
RN [1] {ECO:0000313|Proteomes:UP000007303}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15496914; DOI=10.1038/nature03025;
RA Jaillon O., Aury J.-M., Brunet F., Petit J.-L., Stange-Thomann N.,
RA Mauceli E., Bouneau L., Fischer C., Ozouf-Costaz C., Bernot A., Nicaud S.,
RA Jaffe D., Fisher S., Lutfalla G., Dossat C., Segurens B., Dasilva C.,
RA Salanoubat M., Levy M., Boudet N., Castellano S., Anthouard V., Jubin C.,
RA Castelli V., Katinka M., Vacherie B., Biemont C., Skalli Z., Cattolico L.,
RA Poulain J., De Berardinis V., Cruaud C., Duprat S., Brottier P.,
RA Coutanceau J.-P., Gouzy J., Parra G., Lardier G., Chapple C.,
RA McKernan K.J., McEwan P., Bosak S., Kellis M., Volff J.-N., Guigo R.,
RA Zody M.C., Mesirov J., Lindblad-Toh K., Birren B., Nusbaum C., Kahn D.,
RA Robinson-Rechavi M., Laudet V., Schachter V., Quetier F., Saurin W.,
RA Scarpelli C., Wincker P., Lander E.S., Weissenbach J., Roest Crollius H.;
RT "Genome duplication in the teleost fish Tetraodon nigroviridis reveals the
RT early vertebrate proto-karyotype.";
RL Nature 431:946-957(2004).
RN [2] {ECO:0000313|Ensembl:ENSTNIP00000007242.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
CC -!- SIMILARITY: Belongs to the nicastrin family.
CC {ECO:0000256|ARBA:ARBA00007717}.
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DR AlphaFoldDB; H3CG65; -.
DR STRING; 99883.ENSTNIP00000007242; -.
DR Ensembl; ENSTNIT00000007400.1; ENSTNIP00000007242.1; ENSTNIG00000004593.1.
DR GeneTree; ENSGT00390000014633; -.
DR HOGENOM; CLU_024257_0_0_1; -.
DR InParanoid; H3CG65; -.
DR OMA; ECVYPGV; -.
DR TreeFam; TF317086; -.
DR Proteomes; UP000007303; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProt.
DR GO; GO:0007219; P:Notch signaling pathway; IEA:UniProtKB-KW.
DR GO; GO:0016485; P:protein processing; IEA:InterPro.
DR CDD; cd03881; M28_Nicastrin; 1.
DR Gene3D; 3.40.630.10; Zn peptidases; 1.
DR InterPro; IPR041084; Ncstrn_small.
DR InterPro; IPR008710; Nicastrin.
DR PANTHER; PTHR21092; NICASTRIN; 1.
DR PANTHER; PTHR21092:SF0; NICASTRIN; 1.
DR Pfam; PF18266; Ncstrn_small; 1.
DR Pfam; PF05450; Nicastrin; 1.
DR SUPFAM; SSF53187; Zn-dependent exopeptidases; 1.
PE 3: Inferred from homology;
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Notch signaling pathway {ECO:0000256|ARBA:ARBA00022976};
KW Reference proteome {ECO:0000313|Proteomes:UP000007303};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 641..661
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 16..191
FT /note="Nicastrin small lobe"
FT /evidence="ECO:0000259|Pfam:PF18266"
SQ SEQUENCE 680 AA; 76314 MW; 1727AD0E3E700C37 CRC64;
SSVEKKIYVQ LNYTVPCVRL LNATHQIGCQ STLSGNVGVL HVLESEENLE WVLSSGPNPP
YLVILESQLF TRSVMMKLKN GSNRVAGVAV VAPNVNPSMG FSPHTSCPNE NMGVYSEDYD
PAFAHCNVTV WNPLGNGLSY EQFDFPIFSL KDDNETQLIR QQCYIDHNRA VNNSVPQYPL
CAMQLYSHMS AVTDTRTCMR RSERSSFSLS QEEMCDPLGD YNVWASTRPF NVTSKGHKKL
ESVVIAPARL DSRSFFFDIA PGAESAVSGF VTLLAAANAL RNATQDAQPN RTILYTFFHG
ETFDYIGSSR MVYDMQNNEF VVDLDNVHSV LEIGQVGFQT DSRLWLHSDP VSRRNSSIND
EVRKLIANVE LAAGKSGIAV EEPSFSQPLP PSSFQRFLRA RAIPGLVIED HRSEFTNRFY
ESMYDNAEYF NISYPSNMTQ EEQFDFLTDT AKSLTEVATM VARTLYLQAG GAETQLDNIN
ADAQTVTRML YGFLVRSNNS WFQQILPSER ANHLTNRPPN FYVGVTPYPT ELTYLVQHLL
ANLTGSIVNI TQENCQNQRE NQDDTESKDI YAYAWVQGSK PPNGTERQGF CVRSTARRSK
ASSPAFELHE YTSKDYSTWT ESRWKSIKGR VFLVASHDLQ MLTLGVGFGV LLTSLLVTYI
VSSKADILFS SEREPSNATY
//
