ID H3CGQ1_TETNG Unreviewed; 1927 AA.
AC H3CGQ1;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 1.
DT 27-MAR-2024, entry version 81.
DE SubName: Full=Myosin VIIAa {ECO:0000313|Ensembl:ENSTNIP00000007429.1};
OS Tetraodon nigroviridis (Spotted green pufferfish) (Chelonodon
OS nigroviridis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Tetraodon.
OX NCBI_TaxID=99883 {ECO:0000313|Ensembl:ENSTNIP00000007429.1, ECO:0000313|Proteomes:UP000007303};
RN [1] {ECO:0000313|Proteomes:UP000007303}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15496914; DOI=10.1038/nature03025;
RA Jaillon O., Aury J.-M., Brunet F., Petit J.-L., Stange-Thomann N.,
RA Mauceli E., Bouneau L., Fischer C., Ozouf-Costaz C., Bernot A., Nicaud S.,
RA Jaffe D., Fisher S., Lutfalla G., Dossat C., Segurens B., Dasilva C.,
RA Salanoubat M., Levy M., Boudet N., Castellano S., Anthouard V., Jubin C.,
RA Castelli V., Katinka M., Vacherie B., Biemont C., Skalli Z., Cattolico L.,
RA Poulain J., De Berardinis V., Cruaud C., Duprat S., Brottier P.,
RA Coutanceau J.-P., Gouzy J., Parra G., Lardier G., Chapple C.,
RA McKernan K.J., McEwan P., Bosak S., Kellis M., Volff J.-N., Guigo R.,
RA Zody M.C., Mesirov J., Lindblad-Toh K., Birren B., Nusbaum C., Kahn D.,
RA Robinson-Rechavi M., Laudet V., Schachter V., Quetier F., Saurin W.,
RA Scarpelli C., Wincker P., Lander E.S., Weissenbach J., Roest Crollius H.;
RT "Genome duplication in the teleost fish Tetraodon nigroviridis reveals the
RT early vertebrate proto-karyotype.";
RL Nature 431:946-957(2004).
RN [2] {ECO:0000313|Ensembl:ENSTNIP00000007429.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the TRAFAC class myosin-kinesin ATPase
CC superfamily. Myosin family. {ECO:0000256|ARBA:ARBA00008314,
CC ECO:0000256|PROSITE-ProRule:PRU00782}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00782}.
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DR Ensembl; ENSTNIT00000007587.1; ENSTNIP00000007429.1; ENSTNIG00000004772.1.
DR GeneTree; ENSGT00940000155350; -.
DR Proteomes; UP000007303; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0016459; C:myosin complex; IEA:UniProtKB-KW.
DR GO; GO:0120025; C:plasma membrane bounded cell projection; IEA:UniProt.
DR GO; GO:0003779; F:actin binding; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0003774; F:cytoskeletal motor activity; IEA:InterPro.
DR GO; GO:0048731; P:system development; IEA:UniProt.
DR CDD; cd17092; FERM1_F1_Myosin-VII; 1.
DR CDD; cd17093; FERM2_F1_Myosin-VII; 1.
DR CDD; cd14473; FERM_B-lobe; 2.
DR CDD; cd13198; FERM_C1_MyoVII; 1.
DR CDD; cd13199; FERM_C2_MyoVII; 1.
DR Gene3D; 1.10.10.820; -; 1.
DR Gene3D; 1.20.5.190; -; 2.
DR Gene3D; 1.20.58.530; -; 1.
DR Gene3D; 1.20.80.10; -; 2.
DR Gene3D; 6.20.240.20; -; 1.
DR Gene3D; 3.40.850.10; Kinesin motor domain; 1.
DR Gene3D; 1.20.120.720; Myosin VI head, motor domain, U50 subdomain; 1.
DR Gene3D; 1.25.40.530; MyTH4 domain; 2.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 2.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR019749; Band_41_domain.
DR InterPro; IPR014352; FERM/acyl-CoA-bd_prot_sf.
DR InterPro; IPR035963; FERM_2.
DR InterPro; IPR019748; FERM_central.
DR InterPro; IPR000299; FERM_domain.
DR InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR InterPro; IPR036961; Kinesin_motor_dom_sf.
DR InterPro; IPR001609; Myosin_head_motor_dom.
DR InterPro; IPR041793; MyoVII_FERM_C1.
DR InterPro; IPR041794; MyoVII_FERM_C2.
DR InterPro; IPR000857; MyTH4_dom.
DR InterPro; IPR038185; MyTH4_dom_sf.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR InterPro; IPR029071; Ubiquitin-like_domsf.
DR PANTHER; PTHR22692; MYOSIN VII, XV; 1.
DR PANTHER; PTHR22692:SF34; MYOSIN VIIA; 1.
DR Pfam; PF00373; FERM_M; 2.
DR Pfam; PF00612; IQ; 3.
DR Pfam; PF00063; Myosin_head; 1.
DR Pfam; PF00784; MyTH4; 2.
DR PRINTS; PR00193; MYOSINHEAVY.
DR SMART; SM00295; B41; 2.
DR SMART; SM00015; IQ; 4.
DR SMART; SM00242; MYSc; 1.
DR SMART; SM00139; MyTH4; 2.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF47031; Second domain of FERM; 2.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR SUPFAM; SSF54236; Ubiquitin-like; 2.
DR PROSITE; PS50057; FERM_3; 2.
DR PROSITE; PS50096; IQ; 4.
DR PROSITE; PS51456; MYOSIN_MOTOR; 1.
DR PROSITE; PS51016; MYTH4; 2.
DR PROSITE; PS50002; SH3; 1.
PE 3: Inferred from homology;
KW Actin-binding {ECO:0000256|ARBA:ARBA00023203, ECO:0000256|PROSITE-
KW ProRule:PRU00782}; ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Motor protein {ECO:0000256|ARBA:ARBA00023175};
KW Myosin {ECO:0000256|ARBA:ARBA00023123, ECO:0000256|PROSITE-
KW ProRule:PRU00782}; Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000007303};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 1..486
FT /note="Myosin motor"
FT /evidence="ECO:0000259|PROSITE:PS51456"
FT DOMAIN 763..1000
FT /note="MyTH4"
FT /evidence="ECO:0000259|PROSITE:PS51016"
FT DOMAIN 1005..1314
FT /note="FERM"
FT /evidence="ECO:0000259|PROSITE:PS50057"
FT DOMAIN 1312..1381
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 1456..1607
FT /note="MyTH4"
FT /evidence="ECO:0000259|PROSITE:PS51016"
FT DOMAIN 1613..1917
FT /note="FERM"
FT /evidence="ECO:0000259|PROSITE:PS50057"
FT REGION 363..385
FT /note="Actin-binding"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00782"
FT REGION 649..670
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 719..738
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1927 AA; 223317 MW; 61C41600FF3C2AE4 CRC64;
LCLQACDERN YHIFYCMLNG MTADEKKLGL SRPGDYTYLT MGKCTLCDGR DDTKEYSNIR
SAMKVLMFTD KENWEISKLL AAILHMGNLR YDARTYDNLD ACEVVRSPHL TTSATLLEVD
CKDLMNCLTS RTLITRGETV STPLSMDQAL DVRDAFVKGI YGVVKPMSSQ PKYVRRSIGL
LDIFGFENFT VNSFEQLCIN FANENLQQFF VRHVFKLEQE EYNLEHINWQ HIEFTDNQDA
LDMIAIKPMN IISLIDEESR FPKGTDTTML NKLNFQHKLN SNYIPPKNDH ETQFGIQHFA
GVVYYETRGF LEKNRDTLYG DIIQLVHSSR NKFIKQIFQA DVAMGAETRK RSPTLSSQFK
RSLELLMRTL GVCQPFFVRC IKPNEYKKPM LFDRELCVRQ LRYSGMMETI RIRRAGYPIR
YTFVEFVDRY RVLMPGVKPA YKQEDLRGTC QRISEVVLGR DDDWQMGKTK IFLKDHHDML
LEIERDKAIT DKVILIQKVV RGFKDRSTFL KMRKSATLIQ KTWRGYQCRK NYGAMRVGFS
RLQALVRSRK LCASYHVARQ RITYFQGRCR GFLVRRAFRR RLQAVVIIQA YTRGMIARRL
YKRLRGEYHR RLEAEKMRLA EEVKLRNQMS AKRAKAEAER NHQERLAQLA KEDAEREKNE
KEEARKKKEM VEQMEKARME PVNDSDMVDK MFGFLGTTSS FPGQEGQAPA GFEDLERSHR
ELEEEDLDEA LPLPEDDEEE DLSEYKFAKF AATYFQGTTS YTYVRRPLKQ PLLFHDDEGN
QLAALAVWIT ILRFMGDLPE PKYHTAITDG SEKIPVMTKI YETLGKKTYK RELQALQGEG
EVPQSDSHKK NSVRHKLVSL TLKKKSKITE EVTKRLTDGE YSLHGNSMLE DRPTSNLEKL
HFIIGNGILR PALRRDEIYC QICKQLTQNP SKSSHARGWI LISLCVGCFA PSDKFVKYLR
NFIANGPPGY APYCEERLRR TFVNGTRTQP PSWLELQATK SKKPIMLPVT FMDGTTKTLL
ADSATTAKEL CTALSEKVNL QDRFGFSLYI ALFDKVSSLG SGNDHVMDAV SQCEQYAKEQ
GAQERNAPWR LFFRKEIFTP WHCPSDDHIA TNLIYQQIIR GVKFGEYRCD RKDELAELAS
QQYYIDYGSE VLLERLLSLI PSYIPDREIS TSRTVEKWAH FIMAAHKKGI YAQKRFDPQK
VKEEVVDFAR HKWPLLFSRF YEAFKFSGPT LPKNDLIIAV NWTGVYFVDE QEQVLLEMSF
PEITAVSSSR GSKLQSQSFT LATIKGDEYT FTSNNAEDIR DLVVSFLEGL RKRSKFVVAL
QDNPNPTGEE STFLSFLKGD LIVLDQDTGE QVLNSGWAHG VNERSKLRGD FPADCVYVLP
TMIYPQQELV ALVTMTPAQR QESVRVSQLV LPESVDRVKP YTLEEFSYDY FRPPPKHTLS
RVMVTKNRGK DKLWSCTREP LKQPLLKKVV NHEDLSQEAC LSFIDILEKK YMGDYPSKRT
RSVNELTDQI FEAALKAEPL KDEIYSQIIK QLTDNHVKYS EEKGWELLWL CTGLFPPSNV
LLPHIQRFLQ SKKHHPLSGD CMQRLHKALR NGSRKYPPHL VEVEAIQHKT TQIFHKVYFP
DDTDEAFEVE SSTRAKDFCQ NISSRLLLKS AEGFSLFVKI SDKVISVPEG DFFFDFVRHL
TDWIKKSRPA TKDGIIPCLT YQVFFMKKLW TSTVPGKDSF ADSIFHYYQE LPKYLRGYHK
CSREEVFQLA ALIYRVKFED DKSHFPTIPK MLRELVPQDL IRQMSPDDWK RSVVAYFNKH
AGKSREEAKL MFLKIIYKWP TFGSAFFEVK QTTEPNFPEI LLIAINKHVG MGRYPKTKDI
LTTHPFTKVS NWSSGNTYFH ITIGNLVRGS KLLCEPLLGY KMDDLLTSYI SQMLTTMNKQ
RSGRSQT
//
