ID H3CHH6_TETNG Unreviewed; 1039 AA.
AC H3CHH6;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 1.
DT 27-MAR-2024, entry version 56.
DE RecName: Full=MAM domain-containing protein {ECO:0000259|PROSITE:PS50060};
OS Tetraodon nigroviridis (Spotted green pufferfish) (Chelonodon
OS nigroviridis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Tetraodon.
OX NCBI_TaxID=99883 {ECO:0000313|Ensembl:ENSTNIP00000007704.1, ECO:0000313|Proteomes:UP000007303};
RN [1] {ECO:0000313|Proteomes:UP000007303}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15496914; DOI=10.1038/nature03025;
RA Jaillon O., Aury J.-M., Brunet F., Petit J.-L., Stange-Thomann N.,
RA Mauceli E., Bouneau L., Fischer C., Ozouf-Costaz C., Bernot A., Nicaud S.,
RA Jaffe D., Fisher S., Lutfalla G., Dossat C., Segurens B., Dasilva C.,
RA Salanoubat M., Levy M., Boudet N., Castellano S., Anthouard V., Jubin C.,
RA Castelli V., Katinka M., Vacherie B., Biemont C., Skalli Z., Cattolico L.,
RA Poulain J., De Berardinis V., Cruaud C., Duprat S., Brottier P.,
RA Coutanceau J.-P., Gouzy J., Parra G., Lardier G., Chapple C.,
RA McKernan K.J., McEwan P., Bosak S., Kellis M., Volff J.-N., Guigo R.,
RA Zody M.C., Mesirov J., Lindblad-Toh K., Birren B., Nusbaum C., Kahn D.,
RA Robinson-Rechavi M., Laudet V., Schachter V., Quetier F., Saurin W.,
RA Scarpelli C., Wincker P., Lander E.S., Weissenbach J., Roest Crollius H.;
RT "Genome duplication in the teleost fish Tetraodon nigroviridis reveals the
RT early vertebrate proto-karyotype.";
RL Nature 431:946-957(2004).
RN [2] {ECO:0000313|Ensembl:ENSTNIP00000007704.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00124}.
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DR AlphaFoldDB; H3CHH6; -.
DR Ensembl; ENSTNIT00000007865.1; ENSTNIP00000007704.1; ENSTNIG00000005038.1.
DR GeneTree; ENSGT00940000164732; -.
DR HOGENOM; CLU_008233_0_0_1; -.
DR InParanoid; H3CHH6; -.
DR OMA; CEIRAWY; -.
DR TreeFam; TF330345; -.
DR Proteomes; UP000007303; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:InterPro.
DR CDD; cd00112; LDLa; 1.
DR CDD; cd06263; MAM; 4.
DR Gene3D; 2.60.120.200; -; 6.
DR Gene3D; 4.10.400.10; Low-density Lipoprotein Receptor; 1.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR036055; LDL_receptor-like_sf.
DR InterPro; IPR023415; LDLR_class-A_CS.
DR InterPro; IPR002172; LDrepeatLR_classA_rpt.
DR InterPro; IPR000998; MAM_dom.
DR PANTHER; PTHR23282; APICAL ENDOSOMAL GLYCOPROTEIN PRECURSOR; 1.
DR PANTHER; PTHR23282:SF101; RT07201P-RELATED; 1.
DR Pfam; PF00057; Ldl_recept_a; 1.
DR Pfam; PF00629; MAM; 6.
DR PRINTS; PR00261; LDLRECEPTOR.
DR SMART; SM00192; LDLa; 2.
DR SMART; SM00137; MAM; 4.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 6.
DR SUPFAM; SSF57424; LDL receptor-like module; 1.
DR PROSITE; PS01209; LDLRA_1; 1.
DR PROSITE; PS50068; LDLRA_2; 1.
DR PROSITE; PS50060; MAM_2; 6.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00124}; Reference proteome {ECO:0000313|Proteomes:UP000007303}.
FT DOMAIN 1..113
FT /note="MAM"
FT /evidence="ECO:0000259|PROSITE:PS50060"
FT DOMAIN 164..327
FT /note="MAM"
FT /evidence="ECO:0000259|PROSITE:PS50060"
FT DOMAIN 368..543
FT /note="MAM"
FT /evidence="ECO:0000259|PROSITE:PS50060"
FT DOMAIN 553..705
FT /note="MAM"
FT /evidence="ECO:0000259|PROSITE:PS50060"
FT DOMAIN 707..864
FT /note="MAM"
FT /evidence="ECO:0000259|PROSITE:PS50060"
FT DOMAIN 867..1031
FT /note="MAM"
FT /evidence="ECO:0000259|PROSITE:PS50060"
FT DISULFID 135..153
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 147..162
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
SQ SEQUENCE 1039 AA; 114886 MW; B2EE71D06F1BEB80 CRC64;
VAVTEVESQE RSMAVFISPV IRESAATCRL RLRYFLWNSG LGSTPLWASV VHQDSQEAVV
WRPEATSVRS WREGTVFLSR IPSAFQILFH SHRSRGQRGD VAIDQLEFLD CALPLLSLPT
SSVPSPGEEC AVVRCNNGAC VEERQVCDGT DDCGDGTDEL DCGASCDFEE GLCEWNLASL
SLLKWVRTSQ KNISLSDPLK GPGRDHSTNS VTGHFLYVTV PETGLTNDWA SFQSHLLEPT
NSSHPCKMVM YTHQFGPRSG GLTVLVADGE IYPVWERGGA LGDLWVKAEL EIVTSSDFHI
LIMAAIRDFA YGGVAIDSIR LSPDCRKSSV YHPSSCSTLF FFPPSQLANA PLSKFPRPPK
DPCTEADKMC DFTPDCQQEE DEAKCGAWDF SYPEGSSGWT DTSIGSQGWD LYKNSTTKDL
SCAVEEYLHV VNAPGQQLTG AQTRTPLLGP TGPACTLRSF FFFYVGAAGE LSVRVIDSML
GTQPKLWEFT GKTGTDEEAW RQVNLTIGAR KHRFQLAFEA QAIKISPQTM IKVTNVGFSD
CNVGYIPFRP TGLSCNFEDN LCGWYQDNSD NFDWTLFNGM DHTIGIGRSL TVDVWSPSLR
GLSGRLISYS QPPRSAESCL SFFYKLYGPN TGALNVKLTD TLHFEKLLWT RSGAHCNLWH
EAHCPVPAQI TPFQRFQLIF EVVRSGFDGR VAIDDVSFVG RKCTVPRMCS FEEQLCGFTT
SGWHRRNGRT SAAIGPETDH TLETPVGFYM LANTASYSLP AGQTAVLVSP VHPGNAKIEC
VHFWYNTGGE TPGSLTLYLT FLNGRRVKIF SNSLNQGDTW RHGSGNISSG LQDWQLEFEV
TGAGGEESYI AVDDIVLSAH PCQAQGSTCT LERGMCTWSN TQNIRLDTLD WELTSSQLEK
HYPVPHEDHT LGTERGHFLF LPSSNRTASN GNAYLLSPHL PPTKGTCLKF WAFMPHSYVK
KKKPCSLSIN TANSKLKVWT ITEGQSNEWK HFEINIVSPQ EYQIAFEGIK GVSGFVALDD
IKYTPGVNCD NQLVDPKPG
//
