ID H3CI87_TETNG Unreviewed; 1297 AA.
AC H3CI87;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 1.
DT 27-MAR-2024, entry version 67.
DE RecName: Full=Ankyrin 2 {ECO:0008006|Google:ProtNLM};
OS Tetraodon nigroviridis (Spotted green pufferfish) (Chelonodon
OS nigroviridis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Tetraodon.
OX NCBI_TaxID=99883 {ECO:0000313|Ensembl:ENSTNIP00000007965.1, ECO:0000313|Proteomes:UP000007303};
RN [1] {ECO:0000313|Proteomes:UP000007303}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15496914; DOI=10.1038/nature03025;
RA Jaillon O., Aury J.-M., Brunet F., Petit J.-L., Stange-Thomann N.,
RA Mauceli E., Bouneau L., Fischer C., Ozouf-Costaz C., Bernot A., Nicaud S.,
RA Jaffe D., Fisher S., Lutfalla G., Dossat C., Segurens B., Dasilva C.,
RA Salanoubat M., Levy M., Boudet N., Castellano S., Anthouard V., Jubin C.,
RA Castelli V., Katinka M., Vacherie B., Biemont C., Skalli Z., Cattolico L.,
RA Poulain J., De Berardinis V., Cruaud C., Duprat S., Brottier P.,
RA Coutanceau J.-P., Gouzy J., Parra G., Lardier G., Chapple C.,
RA McKernan K.J., McEwan P., Bosak S., Kellis M., Volff J.-N., Guigo R.,
RA Zody M.C., Mesirov J., Lindblad-Toh K., Birren B., Nusbaum C., Kahn D.,
RA Robinson-Rechavi M., Laudet V., Schachter V., Quetier F., Saurin W.,
RA Scarpelli C., Wincker P., Lander E.S., Weissenbach J., Roest Crollius H.;
RT "Genome duplication in the teleost fish Tetraodon nigroviridis reveals the
RT early vertebrate proto-karyotype.";
RL Nature 431:946-957(2004).
RN [2] {ECO:0000313|Ensembl:ENSTNIP00000007965.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton
CC {ECO:0000256|ARBA:ARBA00004245}. Membrane
CC {ECO:0000256|ARBA:ARBA00004370}.
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DR STRING; 99883.ENSTNIP00000007965; -.
DR Ensembl; ENSTNIT00000008126.1; ENSTNIP00000007965.1; ENSTNIG00000005286.1.
DR GeneTree; ENSGT00940000155279; -.
DR HOGENOM; CLU_000134_7_1_1; -.
DR InParanoid; H3CI87; -.
DR OMA; PESMHET; -.
DR TreeFam; TF351263; -.
DR Proteomes; UP000007303; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0051179; P:localization; IEA:UniProt.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR Gene3D; 2.60.220.30; -; 2.
DR Gene3D; 2.60.40.2660; -; 1.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 3.
DR Gene3D; 1.10.533.10; Death Domain, Fas; 1.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR040745; Ankyrin_UPA.
DR InterPro; IPR011029; DEATH-like_dom_sf.
DR InterPro; IPR000488; Death_domain.
DR InterPro; IPR000906; ZU5_dom.
DR PANTHER; PTHR24198; ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR24198:SF173; ANKYRIN-3; 1.
DR Pfam; PF00023; Ank; 1.
DR Pfam; PF12796; Ank_2; 6.
DR Pfam; PF00531; Death; 1.
DR Pfam; PF17809; UPA_2; 1.
DR Pfam; PF00791; ZU5; 2.
DR PRINTS; PR01415; ANKYRIN.
DR SMART; SM00248; ANK; 17.
DR SMART; SM00005; DEATH; 1.
DR SMART; SM00218; ZU5; 1.
DR SUPFAM; SSF48403; Ankyrin repeat; 2.
DR SUPFAM; SSF47986; DEATH domain; 1.
DR PROSITE; PS50297; ANK_REP_REGION; 17.
DR PROSITE; PS50088; ANK_REPEAT; 17.
DR PROSITE; PS50017; DEATH_DOMAIN; 1.
DR PROSITE; PS51145; ZU5; 2.
PE 4: Predicted;
KW ANK repeat {ECO:0000256|ARBA:ARBA00023043, ECO:0000256|PROSITE-
KW ProRule:PRU00023}; Cytoplasm {ECO:0000256|ARBA:ARBA00023212};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000007303};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT REPEAT 2..34
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 35..67
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 68..100
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 101..133
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 134..166
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 167..199
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 200..232
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 233..253
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 265..297
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 298..330
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 331..363
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 364..396
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 397..429
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 430..462
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 463..495
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 496..528
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 529..561
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT DOMAIN 723..878
FT /note="ZU5"
FT /evidence="ECO:0000259|PROSITE:PS51145"
FT DOMAIN 880..1026
FT /note="ZU5"
FT /evidence="ECO:0000259|PROSITE:PS51145"
FT DOMAIN 1216..1297
FT /note="Death"
FT /evidence="ECO:0000259|PROSITE:PS50017"
SQ SEQUENCE 1297 AA; 141576 MW; 95A5E9451922D8A1 CRC64;
QSGFTPLHIA AHYGNVNVAT LLLNRGAAVD FTARNGITPL HVASKRGNTN MVGLLLDRSS
QIDAKTRDGL TPLHCAARSG HDASVELLLE RGAPLLARTK NGLSALHMAA QGDHVDCVQH
LLRHQAPVDD VTLDYLTALH VAAHCGHYRV TKLLLDKRAN PNARALNGFT PLHIACKKNR
VKVMELLVRY GASIQAVTES GLTPIHVAAF MGHLNIVLLL LQSGASPDVS NIRGETALHM
AARAGQVEVV TLLRNGAMVD ARAREEQTPL HIASRLGKTE IVQLLLQHMA HPDAATTNGY
TPLHISAREG QLETASVLLE AGASHSLATK KGFTPLHVAS KYGSLEVAQL LLRRGAPPDC
AGKNGLTPLH VAAHYDNQRV ALLLLDKGAS PHAAAKNGYT PLHIAAKKHQ VEVAVALLQH
GAATDVLTVQ GVAPLHLVAQ EGHADLAALL LGDGARVDLQ TKSGLTPLHL AAQEDRVGVA
EVLARSGADL DQQTRLGYTP LIVACHYGNA KMVNFLLQKG AVVNAKTKSG YTPLHQAAQQ
GNTHVINLLL QHGAKPNAMT LNGNTALGIA RRLGYISVVD TLRVVTEETV VTTTTVTEKH
KLNVPETMSE VLDVSDEEGD DTVTGDGGEY LRAEDLRELG DDSLPGQYLD GMNYLRFSLD
RSFTPTHACW SPRRSGGVDE GTLSSQQALA LARDKDRDAD LLSWTKEDLD NVALSSSALH
SGFLVSFMVD ARGGAMRGCR HNGLRIIIPP KTCSAPTRVT CRLVKRHRLA TMPPLVEGEG
VASRLVEVGP SGAQFLGPVI VEVPHFAALR GRQRELVVLR TQSGDSWKEH QCEHTQQELN
LVLNGLDEGL DTPEELDRKR VCRIITRDFP EYFAVVSRVK QDSHLIGPEG GVLSSTVVPQ
VQAVFPEGAL TKRIRVGLQA QPVGVDVVRK LLGNKATFSP IVTLEPRRRK FHKPITMTLP
VPPSSQDALF PGFGGDTPTL RLLCSITGGT TPAQWEDITG TTPLTFADDC VSFTTNVSAR
FWLVDCRQTQ ESVGFSSQVY REVICVPYMA RFLVFAKTQD PVEARLRCFC VTDDKADKTL
EQQENFSEVA RSRDVEVLEG KPIYADCLGN LVPLTKSGQH HLFSFFAFKE NRLALFIKVR
DNSQEPCGRL SFMKEPRNYR CLSQSAICNL NITLPPYNRV QRRDRQVDFA RISVRPCAHD
CLVVFAVDPQ DEAERKEQHL AVIAEHLGFS WTELARQLDF GDDKINLIRN ENPNSLQDQS
HALLKLWAET EGEHGTEAAL IKRLTKINRM DIVHLIE
//
