ID H3CII5_TETNG Unreviewed; 816 AA.
AC H3CII5;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 1.
DT 27-MAR-2024, entry version 62.
DE SubName: Full=Ectonucleotide pyrophosphatase/phosphodiesterase 2 {ECO:0000313|Ensembl:ENSTNIP00000008063.1};
GN Name=ENPP2 {ECO:0000313|Ensembl:ENSTNIP00000008063.1};
OS Tetraodon nigroviridis (Spotted green pufferfish) (Chelonodon
OS nigroviridis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Tetraodon.
OX NCBI_TaxID=99883 {ECO:0000313|Ensembl:ENSTNIP00000008063.1, ECO:0000313|Proteomes:UP000007303};
RN [1] {ECO:0000313|Proteomes:UP000007303}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15496914; DOI=10.1038/nature03025;
RA Jaillon O., Aury J.-M., Brunet F., Petit J.-L., Stange-Thomann N.,
RA Mauceli E., Bouneau L., Fischer C., Ozouf-Costaz C., Bernot A., Nicaud S.,
RA Jaffe D., Fisher S., Lutfalla G., Dossat C., Segurens B., Dasilva C.,
RA Salanoubat M., Levy M., Boudet N., Castellano S., Anthouard V., Jubin C.,
RA Castelli V., Katinka M., Vacherie B., Biemont C., Skalli Z., Cattolico L.,
RA Poulain J., De Berardinis V., Cruaud C., Duprat S., Brottier P.,
RA Coutanceau J.-P., Gouzy J., Parra G., Lardier G., Chapple C.,
RA McKernan K.J., McEwan P., Bosak S., Kellis M., Volff J.-N., Guigo R.,
RA Zody M.C., Mesirov J., Lindblad-Toh K., Birren B., Nusbaum C., Kahn D.,
RA Robinson-Rechavi M., Laudet V., Schachter V., Quetier F., Saurin W.,
RA Scarpelli C., Wincker P., Lander E.S., Weissenbach J., Roest Crollius H.;
RT "Genome duplication in the teleost fish Tetraodon nigroviridis reveals the
RT early vertebrate proto-karyotype.";
RL Nature 431:946-957(2004).
RN [2] {ECO:0000313|Ensembl:ENSTNIP00000008063.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR AlphaFoldDB; H3CII5; -.
DR STRING; 99883.ENSTNIP00000008063; -.
DR Ensembl; ENSTNIT00000008226.1; ENSTNIP00000008063.1; ENSTNIG00000005380.1.
DR GeneTree; ENSGT00940000155778; -.
DR HOGENOM; CLU_012256_0_1_1; -.
DR InParanoid; H3CII5; -.
DR OMA; SCEDENK; -.
DR TreeFam; TF330032; -.
DR Proteomes; UP000007303; Unassembled WGS sequence.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0016787; F:hydrolase activity; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR CDD; cd16018; Enpp; 1.
DR CDD; cd00091; NUC; 1.
DR Gene3D; 4.10.410.20; -; 2.
DR Gene3D; 3.40.720.10; Alkaline Phosphatase, subunit A; 1.
DR Gene3D; 3.40.570.10; Extracellular Endonuclease, subunit A; 1.
DR InterPro; IPR017850; Alkaline_phosphatase_core_sf.
DR InterPro; IPR001604; DNA/RNA_non-sp_Endonuclease.
DR InterPro; IPR044929; DNA/RNA_non-sp_Endonuclease_sf.
DR InterPro; IPR020821; Extracellular_endonuc_su_A.
DR InterPro; IPR044925; His-Me_finger_sf.
DR InterPro; IPR002591; Phosphodiest/P_Trfase.
DR InterPro; IPR036024; Somatomedin_B-like_dom_sf.
DR InterPro; IPR001212; Somatomedin_B_dom.
DR PANTHER; PTHR10151; ECTONUCLEOTIDE PYROPHOSPHATASE/PHOSPHODIESTERASE; 1.
DR PANTHER; PTHR10151:SF127; ECTONUCLEOTIDE PYROPHOSPHATASE_PHOSPHODIESTERASE FAMILY MEMBER 2-LIKE; 1.
DR Pfam; PF01223; Endonuclease_NS; 1.
DR Pfam; PF01663; Phosphodiest; 1.
DR Pfam; PF01033; Somatomedin_B; 2.
DR SMART; SM00892; Endonuclease_NS; 1.
DR SMART; SM00477; NUC; 1.
DR SMART; SM00201; SO; 2.
DR SUPFAM; SSF53649; Alkaline phosphatase-like; 1.
DR SUPFAM; SSF54060; His-Me finger endonucleases; 1.
DR SUPFAM; SSF90188; Somatomedin B domain; 2.
DR PROSITE; PS00524; SMB_1; 1.
DR PROSITE; PS50958; SMB_2; 2.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000007303};
KW Secreted {ECO:0000256|ARBA:ARBA00022525}.
FT DOMAIN 1..42
FT /note="SMB"
FT /evidence="ECO:0000259|PROSITE:PS50958"
FT DOMAIN 43..87
FT /note="SMB"
FT /evidence="ECO:0000259|PROSITE:PS50958"
FT REGION 479..510
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 816 AA; 91868 MW; ABC5B4B34E66FDFD CRC64;
GSCQGRCFEL EEAKPPGCRC DNLCKTYYSC CSDFDEHCLK TARGFECSQD RCGEVRNQDH
ACHCSDDCLQ TGDCCSNYRS TCKGETSWVE GDCEEISSAE CPAGFVRPPL IMVSVDGFRA
SYLKKGPSVI PNIHKLRTTC GTSAPYMRPV YPSKTFPNLY TLATGLYPES HGIVGNTMHD
PVFNATFSLR TREKLNHRWW GGQPIWITAE EQGVRAGTFF WPCEPPPVLQ VIPLERRILT
ILKWLHLPDA ERPYVYAVHS EQPDTFGHRL GPLSSELDNP LRELDNVIGQ LMNGLKQMHL
HRCVNVIVVG DHGMEEAHCD WTEFLSNYPV NIEEISLIPG SLGRIRAREP RSSTSQVLQQ
HHLHLLQCKR PGQHFRPYLK QHLPKRLHYA NNRRIEDVQL LMDRKWHIAR KAPEKPRSRC
GFFGDHGFDN MLGSMRQTIF MGHGPSFKFK TSVPEFENIE LYNVMCDLLG LKPAPNNGTH
GSLDHMLRAP PLRPGTPQEV TPPSPTSSQD PAVLPRLGCS CHHESARLWS KLLLEEVTER
VCACVCADRT HLAFGRPAVM FDTQYSLLRH VEFISGYSKE LAVPLWTAYT LPKQEDWTPV
PEVSPACVRA DPRVSADHSQ SCSAYSQHPQ LSYGFLFPPD LATSAASRDE AWLITNTAPM
YPAFKRLWRH LQGALLAYAK DSGGINVLAG PVFDNNYDGL RDSADQIKEW SGGSLLVPTH
FYTVVTSCQE VNRSVEDCGG ALGVFSFLIP HRADNSEACN SAEDESEWVE ELLKRHTARV
RDVEILTGLD LYRSTNLTYV STLSLKTRLH TFQSDD
//
