ID H3CLQ2_TETNG Unreviewed; 684 AA.
AC H3CLQ2;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 1.
DT 27-MAR-2024, entry version 65.
DE SubName: Full=RAS p21 protein activator 3 {ECO:0000313|Ensembl:ENSTNIP00000009181.1};
GN Name=RASA3 {ECO:0000313|Ensembl:ENSTNIP00000009181.1};
OS Tetraodon nigroviridis (Spotted green pufferfish) (Chelonodon
OS nigroviridis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Tetraodon.
OX NCBI_TaxID=99883 {ECO:0000313|Ensembl:ENSTNIP00000009181.1, ECO:0000313|Proteomes:UP000007303};
RN [1] {ECO:0000313|Proteomes:UP000007303}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15496914; DOI=10.1038/nature03025;
RA Jaillon O., Aury J.-M., Brunet F., Petit J.-L., Stange-Thomann N.,
RA Mauceli E., Bouneau L., Fischer C., Ozouf-Costaz C., Bernot A., Nicaud S.,
RA Jaffe D., Fisher S., Lutfalla G., Dossat C., Segurens B., Dasilva C.,
RA Salanoubat M., Levy M., Boudet N., Castellano S., Anthouard V., Jubin C.,
RA Castelli V., Katinka M., Vacherie B., Biemont C., Skalli Z., Cattolico L.,
RA Poulain J., De Berardinis V., Cruaud C., Duprat S., Brottier P.,
RA Coutanceau J.-P., Gouzy J., Parra G., Lardier G., Chapple C.,
RA McKernan K.J., McEwan P., Bosak S., Kellis M., Volff J.-N., Guigo R.,
RA Zody M.C., Mesirov J., Lindblad-Toh K., Birren B., Nusbaum C., Kahn D.,
RA Robinson-Rechavi M., Laudet V., Schachter V., Quetier F., Saurin W.,
RA Scarpelli C., Wincker P., Lander E.S., Weissenbach J., Roest Crollius H.;
RT "Genome duplication in the teleost fish Tetraodon nigroviridis reveals the
RT early vertebrate proto-karyotype.";
RL Nature 431:946-957(2004).
RN [2] {ECO:0000313|Ensembl:ENSTNIP00000009181.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR AlphaFoldDB; H3CLQ2; -.
DR STRING; 99883.ENSTNIP00000009181; -.
DR Ensembl; ENSTNIT00000009352.1; ENSTNIP00000009181.1; ENSTNIG00000006413.1.
DR GeneTree; ENSGT00940000157953; -.
DR HOGENOM; CLU_008096_1_1_1; -.
DR InParanoid; H3CLQ2; -.
DR OMA; WLEMPCA; -.
DR TreeFam; TF105302; -.
DR Proteomes; UP000007303; Unassembled WGS sequence.
DR GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR GO; GO:0046580; P:negative regulation of Ras protein signal transduction; IEA:InterPro.
DR CDD; cd04010; C2B_RasA3; 1.
DR CDD; cd13371; PH_GAP1_mammal-like; 1.
DR CDD; cd05134; RasGAP_RASA3; 1.
DR Gene3D; 2.60.40.150; C2 domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR000008; C2_dom.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR039360; Ras_GTPase.
DR InterPro; IPR037774; RASA3_PH.
DR InterPro; IPR023152; RasGAP_CS.
DR InterPro; IPR001936; RasGAP_dom.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR001562; Znf_Btk_motif.
DR PANTHER; PTHR10194:SF53; RAS GTPASE-ACTIVATING PROTEIN 3; 1.
DR PANTHER; PTHR10194; RAS GTPASE-ACTIVATING PROTEINS; 1.
DR Pfam; PF00779; BTK; 1.
DR Pfam; PF00168; C2; 1.
DR Pfam; PF00169; PH; 1.
DR Pfam; PF00616; RasGAP; 1.
DR SMART; SM00107; BTK; 1.
DR SMART; SM00239; C2; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00323; RasGAP; 1.
DR SUPFAM; SSF49562; C2 domain (Calcium/lipid-binding domain, CaLB); 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS50004; C2; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS00509; RAS_GTPASE_ACTIV_1; 1.
DR PROSITE; PS50018; RAS_GTPASE_ACTIV_2; 1.
DR PROSITE; PS51113; ZF_BTK; 1.
PE 4: Predicted;
KW GTPase activation {ECO:0000256|ARBA:ARBA00022468};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000007303};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00432}.
FT DOMAIN 1..113
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT DOMAIN 180..374
FT /note="Ras-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50018"
FT DOMAIN 426..527
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
SQ SEQUENCE 684 AA; 78334 MW; 31D217C03DD6AE4A CRC64;
RVLECQGLPI INGQCDPYAA VSLLGPSRSD AKKTKVKRKT NNPQFEEVFY FEVTRPLSYT
KRQFDVEEED VDKLTLRVDL WNASNLKFGD EFLGGVRVPL RVLGQAGVHD AWYFLQPRDN
GGKSVKVEEL GSLRLNIVYT EDHVFPSEHY TPLRDLLLHS ADVGPVSAST AHILGEVCRE
KQEAAIPLVR LFLHYGKIVP FISAIAHAEI NRTQDPNTIF RGNSLTSKCI DETMKLAGMH
YLQVTLKPII DEICTEHKPC EIDPVKLKES ENLETNRENL RHYVDHIFRV ITTSGVRCPT
VMCDIFFSLR ESAAIRFQVD PDVRFTAVSS FIFLRFFAPA ILSPNLFHLR PHHPDPATSR
TLTLISKTIQ TLGSLAKSRS ANFKESYMAA FYDYFNEKKY ADAVKNFLDL ISTSGKWDQK
SIETPIMLKE GFMIKRAQGR NRFGMKNFKK RWFRLTNHEF TYHKTKGEGA LCSIPIENIL
AVERLEEESF RMKNMFQVIQ PERALYIQAN NCVEARDWID ILTKVSQCNR KRLSTYHPSA
YLNGHWLCCK MCADTAPGCT PCTGGLPANI QLDIDGDRET ERIYSLFSTY MTKMIKMQEA
CGSKSVYDGP EQEEYSSFVI DDPQETYKTL KLIVSAVQTL EQQHTKYKRD KFKKTKIGSQ
EHPIGDKSFQ CYIRQQSENS TYSI
//
