ID H3CM34_TETNG Unreviewed; 709 AA.
AC H3CM34;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 1.
DT 27-MAR-2024, entry version 59.
DE SubName: Full=Eosinophil peroxidase {ECO:0000313|Ensembl:ENSTNIP00000009314.1};
OS Tetraodon nigroviridis (Spotted green pufferfish) (Chelonodon
OS nigroviridis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Tetraodon.
OX NCBI_TaxID=99883 {ECO:0000313|Ensembl:ENSTNIP00000009314.1, ECO:0000313|Proteomes:UP000007303};
RN [1] {ECO:0000313|Proteomes:UP000007303}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15496914; DOI=10.1038/nature03025;
RA Jaillon O., Aury J.-M., Brunet F., Petit J.-L., Stange-Thomann N.,
RA Mauceli E., Bouneau L., Fischer C., Ozouf-Costaz C., Bernot A., Nicaud S.,
RA Jaffe D., Fisher S., Lutfalla G., Dossat C., Segurens B., Dasilva C.,
RA Salanoubat M., Levy M., Boudet N., Castellano S., Anthouard V., Jubin C.,
RA Castelli V., Katinka M., Vacherie B., Biemont C., Skalli Z., Cattolico L.,
RA Poulain J., De Berardinis V., Cruaud C., Duprat S., Brottier P.,
RA Coutanceau J.-P., Gouzy J., Parra G., Lardier G., Chapple C.,
RA McKernan K.J., McEwan P., Bosak S., Kellis M., Volff J.-N., Guigo R.,
RA Zody M.C., Mesirov J., Lindblad-Toh K., Birren B., Nusbaum C., Kahn D.,
RA Robinson-Rechavi M., Laudet V., Schachter V., Quetier F., Saurin W.,
RA Scarpelli C., Wincker P., Lander E.S., Weissenbach J., Roest Crollius H.;
RT "Genome duplication in the teleost fish Tetraodon nigroviridis reveals the
RT early vertebrate proto-karyotype.";
RL Nature 431:946-957(2004).
RN [2] {ECO:0000313|Ensembl:ENSTNIP00000009314.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR AlphaFoldDB; H3CM34; -.
DR STRING; 99883.ENSTNIP00000009314; -.
DR Ensembl; ENSTNIT00000009485.1; ENSTNIP00000009314.1; ENSTNIG00000006541.1.
DR GeneTree; ENSGT00940000166204; -.
DR HOGENOM; CLU_006087_1_0_1; -.
DR InParanoid; H3CM34; -.
DR OMA; CPQHLEC; -.
DR TreeFam; TF314316; -.
DR Proteomes; UP000007303; Unassembled WGS sequence.
DR GO; GO:0020037; F:heme binding; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0004601; F:peroxidase activity; IEA:InterPro.
DR GO; GO:0006979; P:response to oxidative stress; IEA:InterPro.
DR CDD; cd09824; myeloperoxidase_like; 1.
DR Gene3D; 1.10.640.10; Haem peroxidase domain superfamily, animal type; 1.
DR InterPro; IPR019791; Haem_peroxidase_animal.
DR InterPro; IPR010255; Haem_peroxidase_sf.
DR InterPro; IPR037120; Haem_peroxidase_sf_animal.
DR PANTHER; PTHR11475:SF63; EOSINOPHIL PEROXIDASE; 1.
DR PANTHER; PTHR11475; OXIDASE/PEROXIDASE; 1.
DR Pfam; PF03098; An_peroxidase; 1.
DR PRINTS; PR00457; ANPEROXIDASE.
DR SUPFAM; SSF48113; Heme-dependent peroxidases; 1.
DR PROSITE; PS50292; PEROXIDASE_3; 1.
PE 4: Predicted;
KW Heme {ECO:0000256|PIRSR:PIRSR619791-2};
KW Iron {ECO:0000256|PIRSR:PIRSR619791-2};
KW Metal-binding {ECO:0000256|PIRSR:PIRSR619791-2};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Reference proteome {ECO:0000313|Proteomes:UP000007303}.
FT REGION 330..351
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 689..709
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 454
FT /ligand="heme b"
FT /ligand_id="ChEBI:CHEBI:60344"
FT /ligand_part="Fe"
FT /ligand_part_id="ChEBI:CHEBI:18248"
FT /note="axial binding residue"
FT /evidence="ECO:0000256|PIRSR:PIRSR619791-2"
SQ SEQUENCE 709 AA; 78842 MW; E9243D0ADE655E97 CRC64;
ALQRAIELTD AAYTRTSERV KKSLSEGALR PSDLLAHFKQ IQPSTRTQIW AAELLDNTVE
LIREMVYTHM MVQPSPHALT ELLSVGDAES LLQVTGCSAE LQRPRCDSGC LSERYRSITG
KCNNRSHSRW GAANTPYSRW LPPEYEDAWG APRGWDPEHT YHNFTLPPVR LVSQELLFTR
NDHISLDSAL SHLLVEWGQW IDHDMVQTPQ SPSTAAFRSG ADCTHTCSQE APCFPIQIPL
SDPRNGTQSC MPFFRSAPSC GAGTLPRRHR EQLNGITSFV DASMVYGSSP SLALALRNLS
SPLGSMALNS QHSDQGLAYM PFLPRTQSQL DPCGPRNGSR RSQGNNTSCF QAGDSRANEH
LGMIALHTLF LREHNRLVEE LHLLNPHWGP DTLYQEARKV MGAIHQILTW DHYLPRILGE
DAAARLMPPY RGYDPDVDPG IANVFATAAF RFAHVTVHPV VTRLGPGYTT NPQHPPLPLH
HSLFASWRIV QVSGGIDPVL RGLLLSPAKL QSPGQMMVEE LTERLFQAQG GMPFDLAALN
LQRGRDHGLP GYGSWRRFCG LPVPNTTTDL AEILHNLTLA HTFQLLYGTP HNIDVWVGAI
AEPAVPGGRV GPLLACLLSR QFRALRDGDR FWWEKEGVFS EAQRERLRSV SLSRIICDNS
RIARVPADPF SHAGKVEDTL PCSHPLIPRL DLQPWKEPDS GEEDSAPSF
//
