ID H3CN74_TETNG Unreviewed; 647 AA.
AC H3CN74;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 1.
DT 27-MAR-2024, entry version 65.
DE RecName: Full=RNA polymerase II-associated protein 3 {ECO:0000256|ARBA:ARBA00040133};
OS Tetraodon nigroviridis (Spotted green pufferfish) (Chelonodon
OS nigroviridis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Tetraodon.
OX NCBI_TaxID=99883 {ECO:0000313|Ensembl:ENSTNIP00000009705.1, ECO:0000313|Proteomes:UP000007303};
RN [1] {ECO:0000313|Proteomes:UP000007303}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15496914; DOI=10.1038/nature03025;
RA Jaillon O., Aury J.-M., Brunet F., Petit J.-L., Stange-Thomann N.,
RA Mauceli E., Bouneau L., Fischer C., Ozouf-Costaz C., Bernot A., Nicaud S.,
RA Jaffe D., Fisher S., Lutfalla G., Dossat C., Segurens B., Dasilva C.,
RA Salanoubat M., Levy M., Boudet N., Castellano S., Anthouard V., Jubin C.,
RA Castelli V., Katinka M., Vacherie B., Biemont C., Skalli Z., Cattolico L.,
RA Poulain J., De Berardinis V., Cruaud C., Duprat S., Brottier P.,
RA Coutanceau J.-P., Gouzy J., Parra G., Lardier G., Chapple C.,
RA McKernan K.J., McEwan P., Bosak S., Kellis M., Volff J.-N., Guigo R.,
RA Zody M.C., Mesirov J., Lindblad-Toh K., Birren B., Nusbaum C., Kahn D.,
RA Robinson-Rechavi M., Laudet V., Schachter V., Quetier F., Saurin W.,
RA Scarpelli C., Wincker P., Lander E.S., Weissenbach J., Roest Crollius H.;
RT "Genome duplication in the teleost fish Tetraodon nigroviridis reveals the
RT early vertebrate proto-karyotype.";
RL Nature 431:946-957(2004).
RN [2] {ECO:0000313|Ensembl:ENSTNIP00000009705.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the RPAP3 family.
CC {ECO:0000256|ARBA:ARBA00038275}.
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DR AlphaFoldDB; H3CN74; -.
DR STRING; 99883.ENSTNIP00000009705; -.
DR Ensembl; ENSTNIT00000009881.1; ENSTNIP00000009705.1; ENSTNIG00000006908.1.
DR GeneTree; ENSGT00940000156749; -.
DR HOGENOM; CLU_023272_1_0_1; -.
DR InParanoid; H3CN74; -.
DR OMA; NFTPDRP; -.
DR TreeFam; TF106243; -.
DR Proteomes; UP000007303; Unassembled WGS sequence.
DR Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 2.
DR InterPro; IPR025986; RPAP3-like_C.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR InterPro; IPR001440; TPR_1.
DR InterPro; IPR013105; TPR_2.
DR InterPro; IPR019734; TPR_repeat.
DR PANTHER; PTHR46423; RNA POLYMERASE II-ASSOCIATED PROTEIN 3; 1.
DR PANTHER; PTHR46423:SF1; RNA POLYMERASE II-ASSOCIATED PROTEIN 3; 1.
DR Pfam; PF13877; RPAP3_C; 1.
DR Pfam; PF00515; TPR_1; 2.
DR Pfam; PF07719; TPR_2; 1.
DR Pfam; PF13181; TPR_8; 2.
DR SMART; SM00028; TPR; 6.
DR SUPFAM; SSF48452; TPR-like; 2.
DR PROSITE; PS50005; TPR; 4.
DR PROSITE; PS50293; TPR_REGION; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000007303};
KW TPR repeat {ECO:0000256|ARBA:ARBA00022803, ECO:0000256|PROSITE-
KW ProRule:PRU00339}.
FT REPEAT 136..169
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT REPEAT 204..237
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT REPEAT 284..317
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT REPEAT 352..385
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT DOMAIN 527..618
FT /note="RNA-polymerase II-associated protein 3-like C-
FT terminal"
FT /evidence="ECO:0000259|Pfam:PF13877"
FT REGION 35..93
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 111..133
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 421..532
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 35..62
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 432..451
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 452..477
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 491..505
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 512..526
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 647 AA; 72270 MW; C7EE71038E835823 CRC64;
MSGTNKSMEL HLQMRHNTED LVSFMRDLEN WETDIKKKDE ELRTGRVQEA QKKLPPVRNK
DYKSKMRAKK KKSGPTVNGK AKGDENQKDP RIKSYDYTSW EKFDVDKALS EMDKEDSPAG
SNDSDSEDAA VDREKALAEK EKGNAFFRDG KYDAAIECYT RGMSADPYNP VLPTNRATSF
FRLKKYAVAE SDCNLAIALD GKYMKAYARR GAARFALEKY ESALEDYETV LKLSPGNVEA
LCEGKKIKEI LGHQVQGDAS EAAQPEATQG QRRRIEAQRR QQEAVFHKDR GNAYFKEGKY
EAAVECYSQG MEADGTNIFL PANRAMAYLK LQRYTEAEED CSRALALDGS YSKALARRAT
ARAALGKLQE AKQDFEEVLK LEPGNKQALN ELQKLQANVV ADRGEWGKVM SSSGVPITQR
RTVQPVDKPP HLRSAKPLRR IEIEEVSGST EHRSVGSKPI TQEVGAQQSS PLSTSPSAKM
IKIEEVAEVP SQSPDPTQTQ QARQEEVADG APPPCSPSPS DTELPPPPSN SFQLEAQLHK
IGNQPEVVYR YLRQIKPEDY GSVLHSWLEP DVLHKILRTL RDFYLKSEGP AVALEVLRSL
AGVGRFDMAV MFMSSAEKKV VSDLFDFLRQ ADLDASAVTA LQQKYGV
//
