ID H3CND5_TETNG Unreviewed; 428 AA.
AC H3CND5;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 1.
DT 27-MAR-2024, entry version 47.
DE SubName: Full=Divergent protein kinase domain 1Aa {ECO:0000313|Ensembl:ENSTNIP00000009766.1};
OS Tetraodon nigroviridis (Spotted green pufferfish) (Chelonodon
OS nigroviridis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Tetraodon.
OX NCBI_TaxID=99883 {ECO:0000313|Ensembl:ENSTNIP00000009766.1, ECO:0000313|Proteomes:UP000007303};
RN [1] {ECO:0000313|Proteomes:UP000007303}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15496914; DOI=10.1038/nature03025;
RA Jaillon O., Aury J.-M., Brunet F., Petit J.-L., Stange-Thomann N.,
RA Mauceli E., Bouneau L., Fischer C., Ozouf-Costaz C., Bernot A., Nicaud S.,
RA Jaffe D., Fisher S., Lutfalla G., Dossat C., Segurens B., Dasilva C.,
RA Salanoubat M., Levy M., Boudet N., Castellano S., Anthouard V., Jubin C.,
RA Castelli V., Katinka M., Vacherie B., Biemont C., Skalli Z., Cattolico L.,
RA Poulain J., De Berardinis V., Cruaud C., Duprat S., Brottier P.,
RA Coutanceau J.-P., Gouzy J., Parra G., Lardier G., Chapple C.,
RA McKernan K.J., McEwan P., Bosak S., Kellis M., Volff J.-N., Guigo R.,
RA Zody M.C., Mesirov J., Lindblad-Toh K., Birren B., Nusbaum C., Kahn D.,
RA Robinson-Rechavi M., Laudet V., Schachter V., Quetier F., Saurin W.,
RA Scarpelli C., Wincker P., Lander E.S., Weissenbach J., Roest Crollius H.;
RT "Genome duplication in the teleost fish Tetraodon nigroviridis reveals the
RT early vertebrate proto-karyotype.";
RL Nature 431:946-957(2004).
RN [2] {ECO:0000313|Ensembl:ENSTNIP00000009766.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC {ECO:0000256|ARBA:ARBA00004648}; Single-pass type II membrane protein
CC {ECO:0000256|ARBA:ARBA00004648}. Membrane
CC {ECO:0000256|ARBA:ARBA00004606}; Single-pass type II membrane protein
CC {ECO:0000256|ARBA:ARBA00004606}.
CC -!- SIMILARITY: Belongs to the DIPK family.
CC {ECO:0000256|ARBA:ARBA00006338}.
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DR AlphaFoldDB; H3CND5; -.
DR Ensembl; ENSTNIT00000009943.1; ENSTNIP00000009766.1; ENSTNIG00000006968.1.
DR GeneTree; ENSGT00390000006452; -.
DR HOGENOM; CLU_039177_0_0_1; -.
DR InParanoid; H3CND5; -.
DR OMA; TMRVLKC; -.
DR TreeFam; TF313319; -.
DR Proteomes; UP000007303; Unassembled WGS sequence.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR InterPro; IPR022049; FAM69_kinase_dom.
DR InterPro; IPR029244; FAM69_N.
DR PANTHER; PTHR21093:SF8; DIVERGENT PROTEIN KINASE DOMAIN 1A; 1.
DR PANTHER; PTHR21093; UNCHARACTERIZED; 1.
DR Pfam; PF12260; PIP49_C; 1.
DR Pfam; PF14875; PIP49_N; 1.
DR SMART; SM01299; PIP49_N; 1.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Endoplasmic reticulum {ECO:0000256|ARBA:ARBA00022824};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000007303};
KW Signal-anchor {ECO:0000256|ARBA:ARBA00022968};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 28..47
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 19..177
FT /note="FAM69 N-terminal"
FT /evidence="ECO:0000259|SMART:SM01299"
SQ SEQUENCE 428 AA; 48545 MW; A0D316D08F5070ED CRC64;
MAKALFPRAW VKKSFYFQAR ISFVRVKYLF LTWLTVLVGS WVVYVQYSAY TELCRGRECR
SAICDKYRKG VIAGSACSSL CDKETLYMSR CLSTLPNNQV YTGSWGDHDG IIRCKLGEVL
HYELGEEPEP RREAPVFDKP TRGTSVEKFR EMVFNHLRSK LGEQANLAGL VGQILAFSDG
NKDGRVSLAE ARSAWALLQM DEVLLGLLLQ DRGHTPRLLG YCGDLYMVER VPYGPLYGLS
LPWPLVSWVP GGLQRTMDQW FTPSWPRKAK ISMGLLELVE DIFHGPYGSF LICDLAAVHF
GYTERHELRL TNTRAVVPER QLRRAMRTLK CESDGDCVYG VDCRTTCDLS ENRCREETLQ
PNLAKACGAL KDYVLRGAPS ALREELERQL YACMALNGNA GQMNMEHSLI LNNLKALLWR
QISHTKDS
//
