ID H3CNH8_TETNG Unreviewed; 402 AA.
AC H3CNH8;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 1.
DT 27-MAR-2024, entry version 62.
DE SubName: Full=Failed axon connections homolog, metaxin like GST domain containing {ECO:0000313|Ensembl:ENSTNIP00000009810.1};
GN Name=FAXC {ECO:0000313|Ensembl:ENSTNIP00000009810.1};
OS Tetraodon nigroviridis (Spotted green pufferfish) (Chelonodon
OS nigroviridis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Tetraodon.
OX NCBI_TaxID=99883 {ECO:0000313|Ensembl:ENSTNIP00000009810.1, ECO:0000313|Proteomes:UP000007303};
RN [1] {ECO:0000313|Proteomes:UP000007303}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15496914; DOI=10.1038/nature03025;
RA Jaillon O., Aury J.-M., Brunet F., Petit J.-L., Stange-Thomann N.,
RA Mauceli E., Bouneau L., Fischer C., Ozouf-Costaz C., Bernot A., Nicaud S.,
RA Jaffe D., Fisher S., Lutfalla G., Dossat C., Segurens B., Dasilva C.,
RA Salanoubat M., Levy M., Boudet N., Castellano S., Anthouard V., Jubin C.,
RA Castelli V., Katinka M., Vacherie B., Biemont C., Skalli Z., Cattolico L.,
RA Poulain J., De Berardinis V., Cruaud C., Duprat S., Brottier P.,
RA Coutanceau J.-P., Gouzy J., Parra G., Lardier G., Chapple C.,
RA McKernan K.J., McEwan P., Bosak S., Kellis M., Volff J.-N., Guigo R.,
RA Zody M.C., Mesirov J., Lindblad-Toh K., Birren B., Nusbaum C., Kahn D.,
RA Robinson-Rechavi M., Laudet V., Schachter V., Quetier F., Saurin W.,
RA Scarpelli C., Wincker P., Lander E.S., Weissenbach J., Roest Crollius H.;
RT "Genome duplication in the teleost fish Tetraodon nigroviridis reveals the
RT early vertebrate proto-karyotype.";
RL Nature 431:946-957(2004).
RN [2] {ECO:0000313|Ensembl:ENSTNIP00000009810.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the FAX family. {ECO:0000256|ARBA:ARBA00006475}.
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DR AlphaFoldDB; H3CNH8; -.
DR STRING; 99883.ENSTNIP00000009810; -.
DR Ensembl; ENSTNIT00000009988.1; ENSTNIP00000009810.1; ENSTNIG00000007011.1.
DR GeneTree; ENSGT00950000182919; -.
DR HOGENOM; CLU_044137_2_0_1; -.
DR InParanoid; H3CNH8; -.
DR OMA; WIEYNHT; -.
DR TreeFam; TF314915; -.
DR Proteomes; UP000007303; Unassembled WGS sequence.
DR CDD; cd03193; GST_C_Metaxin; 1.
DR CDD; cd03080; GST_N_Metaxin_like; 1.
DR Gene3D; 1.20.1050.10; -; 1.
DR Gene3D; 3.40.30.10; Glutaredoxin; 1.
DR InterPro; IPR026928; FAX/IsoI-like.
DR InterPro; IPR045796; FAXC_N.
DR InterPro; IPR036282; Glutathione-S-Trfase_C_sf.
DR InterPro; IPR033468; Metaxin_GST.
DR InterPro; IPR012336; Thioredoxin-like_fold.
DR InterPro; IPR036249; Thioredoxin-like_sf.
DR PANTHER; PTHR12289:SF76; FAILED AXON CONNECTIONS HOMOLOG; 1.
DR PANTHER; PTHR12289; METAXIN RELATED; 1.
DR Pfam; PF19333; FAXC_N; 1.
DR Pfam; PF17171; GST_C_6; 1.
DR Pfam; PF17172; GST_N_4; 1.
DR SFLD; SFLDG01180; SUF1; 1.
DR SFLD; SFLDG01200; SUF1.1; 1.
DR SUPFAM; SSF47616; GST C-terminal domain-like; 1.
DR SUPFAM; SSF52833; Thioredoxin-like; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000007303}.
FT DOMAIN 1..104
FT /note="Failed axon connections homolog N-terminal"
FT /evidence="ECO:0000259|Pfam:PF19333"
FT DOMAIN 115..208
FT /note="Thioredoxin-like fold"
FT /evidence="ECO:0000259|Pfam:PF17172"
FT DOMAIN 260..322
FT /note="Metaxin glutathione S-transferase"
FT /evidence="ECO:0000259|Pfam:PF17171"
FT REGION 368..402
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 368..393
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 402 AA; 45605 MW; 2693CC581A5E8EE0 CRC64;
MYWAAGFASS RPCVVELGRN HSLPLRLCGS EQQQSLYGYI IAFPLQDYGG IMSVLGSDSW
WKKTLYITGG ALLAAAAYLL HELLAIRKEQ ELDSKDAIVL HQFSRPKNGV PSLSPSCLKI
ETYLRMLDLP YQNYFDGKLS PQGKMPWIEY NHQRVSGSEF MVDFLEEKLG VNLNLDLTPQ
ERAVSRAVTK MVEEHLYWTI AYCQWVDNLE ETQQLLAVSG PMSDTLKWLL SHLNGGMVRR
EMYGHGIGRF SREEVYALME KDMRTLATLL GDKKYFMGSK ISTLDATVFG HLAQAMWTLP
GTRPEQLIKG ELINLAMFCE RIRRRFWPEW FVEVEDLYYD GDSESSGASS QEGLLDFGLF
SRTDTLDNSD ARNTHTNCPD SDHSLFDSDV GTGSDNDTHP KE
//
