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Database: UniProt
Entry: H3CQ58_TETNG
LinkDB: H3CQ58_TETNG
Original site: H3CQ58_TETNG 
ID   H3CQ58_TETNG            Unreviewed;      1590 AA.
AC   H3CQ58;
DT   18-APR-2012, integrated into UniProtKB/TrEMBL.
DT   18-APR-2012, sequence version 1.
DT   28-MAR-2018, entry version 41.
DE   SubName: Full=Calcium channel, voltage-dependent, L type, alpha 1C subunit {ECO:0000313|Ensembl:ENSTNIP00000010392};
OS   Tetraodon nigroviridis (Spotted green pufferfish) (Chelonodon
OS   nigroviridis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae;
OC   Tetraodon.
OX   NCBI_TaxID=99883 {ECO:0000313|Ensembl:ENSTNIP00000010392, ECO:0000313|Proteomes:UP000007303};
RN   [1] {ECO:0000313|Ensembl:ENSTNIP00000010392}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15496914; DOI=10.1038/nature03025;
RA   Jaillon O., Aury J.-M., Brunet F., Petit J.-L., Stange-Thomann N.,
RA   Mauceli E., Bouneau L., Fischer C., Ozouf-Costaz C., Bernot A.,
RA   Nicaud S., Jaffe D., Fisher S., Lutfalla G., Dossat C., Segurens B.,
RA   Dasilva C., Salanoubat M., Levy M., Boudet N., Castellano S.,
RA   Anthouard V., Jubin C., Castelli V., Katinka M., Vacherie B.,
RA   Biemont C., Skalli Z., Cattolico L., Poulain J., De Berardinis V.,
RA   Cruaud C., Duprat S., Brottier P., Coutanceau J.-P., Gouzy J.,
RA   Parra G., Lardier G., Chapple C., McKernan K.J., McEwan P., Bosak S.,
RA   Kellis M., Volff J.-N., Guigo R., Zody M.C., Mesirov J.,
RA   Lindblad-Toh K., Birren B., Nusbaum C., Kahn D., Robinson-Rechavi M.,
RA   Laudet V., Schachter V., Quetier F., Saurin W., Scarpelli C.,
RA   Wincker P., Lander E.S., Weissenbach J., Roest Crollius H.;
RT   "Genome duplication in the teleost fish Tetraodon nigroviridis reveals
RT   the early vertebrate proto-karyotype.";
RL   Nature 431:946-957(2004).
RN   [2] {ECO:0000313|Ensembl:ENSTNIP00000010392}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (FEB-2012) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|RuleBase:RU003808};
CC       Multi-pass membrane protein {ECO:0000256|RuleBase:RU003808}.
CC   -!- SIMILARITY: Belongs to the calcium channel alpha-1 subunit
CC       (TC 1.A.1.11) family. {ECO:0000256|RuleBase:RU003808}.
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DR   STRING; 99883.ENSTNIP00000010392; -.
DR   Ensembl; ENSTNIT00000010573; ENSTNIP00000010392; ENSTNIG00000007580.
DR   eggNOG; KOG2301; Eukaryota.
DR   eggNOG; ENOG410XNP6; LUCA.
DR   GeneTree; ENSGT00830000128247; -.
DR   InParanoid; H3CQ58; -.
DR   OMA; PTTKINM; -.
DR   OrthoDB; EOG091G0TKO; -.
DR   TreeFam; TF312805; -.
DR   Proteomes; UP000007303; Unassembled WGS sequence.
DR   GO; GO:0005891; C:voltage-gated calcium channel complex; IEA:InterPro.
DR   GO; GO:0005245; F:voltage-gated calcium channel activity; IEA:Ensembl.
DR   GO; GO:0070509; P:calcium ion import; IEA:Ensembl.
DR   GO; GO:0048701; P:embryonic cranial skeleton morphogenesis; IEA:Ensembl.
DR   GO; GO:0001947; P:heart looping; IEA:Ensembl.
DR   GO; GO:0001822; P:kidney development; IEA:Ensembl.
DR   GO; GO:0003301; P:physiological cardiac muscle hypertrophy; IEA:Ensembl.
DR   GO; GO:0008016; P:regulation of heart contraction; IEA:Ensembl.
DR   GO; GO:0034765; P:regulation of ion transmembrane transport; IEA:UniProtKB-KW.
DR   Gene3D; 1.20.120.350; -; 4.
DR   InterPro; IPR031649; GPHH_dom.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR014873; VDCC_a1su_IQ.
DR   InterPro; IPR002077; VDCCAlpha1.
DR   InterPro; IPR027359; Volt_channel_dom_sf.
DR   Pfam; PF08763; Ca_chan_IQ; 1.
DR   Pfam; PF16905; GPHH; 1.
DR   Pfam; PF00520; Ion_trans; 4.
DR   PRINTS; PR00167; CACHANNEL.
DR   SMART; SM01062; Ca_chan_IQ; 1.
PE   3: Inferred from homology;
KW   Calcium {ECO:0000256|RuleBase:RU003808};
KW   Calcium channel {ECO:0000256|RuleBase:RU003808};
KW   Calcium transport {ECO:0000256|RuleBase:RU003808};
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000007303};
KW   Ion channel {ECO:0000256|RuleBase:RU003808};
KW   Ion transport {ECO:0000256|RuleBase:RU003808};
KW   Membrane {ECO:0000256|SAAS:SAAS00085096, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000007303};
KW   Transmembrane {ECO:0000256|SAAS:SAAS00084820,
KW   ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAAS:SAAS00084701,
KW   ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|RuleBase:RU003808};
KW   Voltage-gated channel {ECO:0000256|RuleBase:RU003808}.
FT   TRANSMEM      5     26       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM     38     59       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM     94    116       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    174    195       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    207    229       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    360    377       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    397    420       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    489    508       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    556    578       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    896    914       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    934    954       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1012   1041       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1187   1205       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1217   1238       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1250   1267       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1312   1331       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1403   1427       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN     1561   1589       Ca_chan_IQ. {ECO:0000259|SMART:SM01062}.
FT   COILED      589    615       {ECO:0000256|SAM:Coils}.
FT   COILED     1522   1542       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   1590 AA;  182147 MW;  F6680327CF6C41E2 CRC64;
     EQVEYLFLII FTVEAFLKVI AYGLLFHPNA YLRNGWNLLD FIIVVVGGII GGKAAGFDVK
     ALRAFRVLRP LRLVSGVPSL QVVLNSIIKA MVPLLHIALL VLFVIIIYAI IGLELFMGKM
     HKTCFHSHLE ILAEEQPAPC APEGGYGRHC TRNGTMCKMG WEGPNNGITN FDNFAFAMLT
     VFQCITMEGW TEVLYWVNDA VGYEWPWLYF VTLIIIGSFF VLNLVLGVLS GEFSKEREKA
     KARGDFQKLR EKQQLEEDLK GYLDWITQAE DIDPENEEEG LDDDKPRNRS GASRRAKVPQ
     AKTDRSNKKE CSSKCLNIAL STSPLARRSF MSSRINDTRY SRRWNRLFRR KCRAGVKSQV
     FYWLVIFLVF LNTLTIASEH HQQPQWLTDI QDIANKVLLA LFTGEMLLKM YSLGLQAYFV
     SLFNRFDSFV VCGGILETIL VETKIMSPLG ISVLRCVRLL RIFKITRYWN SLSNLVASLL
     NSVRSIASLL LLLFLFIIIF SLLGMQLFGG KFNFEETRRS TFDNFPQSLL TVFQILTGED
     WNSVMYDGIM AYGGPAFPGM LVCIYFIILF ICGNYILLNV FLAIAVDNLA DAESLTSAQK
     EEEEEKERKK LARRKKDTIT ISYKLNDDKY ARFQLFYCNT SLLTVLTVIN RRRGYFPWHK
     SLTVCLDTVC IDRREKCRLL VLFKTAQNPT GIEIHIIIDT SGNYFHNQGR KYTTVVVLKC
     SVFYEGNTTL TLSSPEKRHN NEKPPLEEEK KEKIELKSIT SDGEANTATK EQITSPSNRQ
     ESKCADVSLQ INMDDYCGDN SEEKNPYPAN DYIGTSINEV LMNLPLIIRF YFLASLSLGD
     EDDDEPEMPV GPRPRPLSDI QLKEKVVPMP EARAFFVFSH TNKFRITCHK IVNHNIFTNL
     ILFFILLSSI SLAAEDPVKY DSSRNQILGY ADHVFTGLFT IEIILKMTAY GAFLHKGSFC
     RNYFNILDLV VVSVSLISSG IQSSAINVVK ILRVLRVLRP LRAINRAKGL KHVVQCVFVA
     IRTIGNIVIV TTLLQFMFAC IGVQLFKGKF FSCTDNSKQT QAECRGSYIE YKDGDVGKPE
     RAQRIWKNSE FNFDNVLQGM MALFAVSTFE GWPGLLYRAI DSVAEDVGPI YNYRAFQEQG
     EQEYKNCELD KNQRQCVEYA LKARPLRRYI PKNPYQYKVW YVVNSTYFEY LMFTLILLNT
     ICLAMQHHGQ TKSFNNAMNI LNMLFTGLFT VEMILKLIAF KPRGYFSDPW NVFDFLIVIG
     SIIDVILSEI NNARISITFF RLFRVMRLVK LLSRGEGIRT LLWTFIKSFQ ALPYVALLIV
     MLFFIYAVIG MQMFGKIALR DNTEINRNNN FQTFPQAVLL LFRCATGEAW QEIMLACTPN
     RPCEKGSTNE TNQSAEDCGS HFAIIYFVSF YMLCAFLIIN LFVAVIMDNF DYLTRDWSIL
     GPHHLDEFKR IWAEYDPEAK GRIKHLDVVT LLRRIQPPLG FGKLCPHRVA CKRLVSMNMP
     LNSDGTVMFN ATLFALVRTA LRIKTEGNLE QANEELRAIV KKIWKRTSMK LLDQVVPPAG
     DDEVTVGKFY ATFLIQEYFR KFKKRKEQGL
//
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