ID H3CQH3_TETNG Unreviewed; 738 AA.
AC H3CQH3;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 1.
DT 27-MAR-2024, entry version 48.
DE SubName: Full=G protein-coupled receptor 149 {ECO:0000313|Ensembl:ENSTNIP00000010507.1};
GN Name=GPR149 {ECO:0000313|Ensembl:ENSTNIP00000010507.1};
OS Tetraodon nigroviridis (Spotted green pufferfish) (Chelonodon
OS nigroviridis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Tetraodon.
OX NCBI_TaxID=99883 {ECO:0000313|Ensembl:ENSTNIP00000010507.1, ECO:0000313|Proteomes:UP000007303};
RN [1] {ECO:0000313|Proteomes:UP000007303}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15496914; DOI=10.1038/nature03025;
RA Jaillon O., Aury J.-M., Brunet F., Petit J.-L., Stange-Thomann N.,
RA Mauceli E., Bouneau L., Fischer C., Ozouf-Costaz C., Bernot A., Nicaud S.,
RA Jaffe D., Fisher S., Lutfalla G., Dossat C., Segurens B., Dasilva C.,
RA Salanoubat M., Levy M., Boudet N., Castellano S., Anthouard V., Jubin C.,
RA Castelli V., Katinka M., Vacherie B., Biemont C., Skalli Z., Cattolico L.,
RA Poulain J., De Berardinis V., Cruaud C., Duprat S., Brottier P.,
RA Coutanceau J.-P., Gouzy J., Parra G., Lardier G., Chapple C.,
RA McKernan K.J., McEwan P., Bosak S., Kellis M., Volff J.-N., Guigo R.,
RA Zody M.C., Mesirov J., Lindblad-Toh K., Birren B., Nusbaum C., Kahn D.,
RA Robinson-Rechavi M., Laudet V., Schachter V., Quetier F., Saurin W.,
RA Scarpelli C., Wincker P., Lander E.S., Weissenbach J., Roest Crollius H.;
RT "Genome duplication in the teleost fish Tetraodon nigroviridis reveals the
RT early vertebrate proto-karyotype.";
RL Nature 431:946-957(2004).
RN [2] {ECO:0000313|Ensembl:ENSTNIP00000010507.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR AlphaFoldDB; H3CQH3; -.
DR STRING; 99883.ENSTNIP00000010507; -.
DR Ensembl; ENSTNIT00000010688.1; ENSTNIP00000010507.1; ENSTNIG00000007691.1.
DR GeneTree; ENSGT00390000003715; -.
DR HOGENOM; CLU_021967_0_0_1; -.
DR InParanoid; H3CQH3; -.
DR OMA; TKVVLWL; -.
DR TreeFam; TF331679; -.
DR Proteomes; UP000007303; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:InterPro.
DR CDD; cd15011; 7tmA_GPR149; 1.
DR Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR PANTHER; PTHR24229:SF32; G-PROTEIN COUPLED RECEPTOR 149-RELATED; 1.
DR PANTHER; PTHR24229; NEUROPEPTIDES RECEPTOR; 1.
DR Pfam; PF00001; 7tm_1; 1.
DR SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 4: Predicted;
KW G-protein coupled receptor {ECO:0000256|ARBA:ARBA00023040};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Reference proteome {ECO:0000313|Proteomes:UP000007303};
KW Transducer {ECO:0000256|ARBA:ARBA00023224};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 35..57
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 69..92
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 112..135
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 147..169
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 189..214
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 307..327
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 51..356
FT /note="G-protein coupled receptors family 1 profile"
FT /evidence="ECO:0000259|PROSITE:PS50262"
FT REGION 1..25
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..20
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 738 AA; 81088 MW; BC714AB5ADF63882 CRC64;
MTTTHSSSPA PNQSDPSVDP SEKTDPAGLE RQIRLLLFGL CVTIAAATFA GGVYSLLSLL
RARRKTSLCL IVASMSVDDL LSVVPLSLFM LFQWETDGRE GSASLCTLSG LLYVFQGVSS
NMKACLIAAY TFYVTKRFGV LQSIRRPVRV MWAIAGVWAV SLTVSVLPLC GWGSFAQASL
GCFPKSDSFY ILLLFALYSL CFCGLLFFFI PLTYQLLCSR EPQRTLLDPS YLQMAGGLDG
SPPFCDLQSF SRHSLNKSFG AYNELNPSSC RTEVRERGSS CVPPGNGQET AAVEDTPVVF
AQKRFSMILA IVRIILWMPL MTTVLLRHVL NASISSLETL SFFLTLLAPA VTPLFVLSER
WIHMPCGCFI NCKQAPRRGP SVKKRRFEFN LSFQQGYGVY KLSHATLSPA LENPACRTYF
NCDFSHPRLD VLETGGLSNL GPDFDLSTPC PADSSSHANL LLEAGLSKAL AEHPPVPREN
HEEDADFRCL ASLASHQDND LGDTSSVFEG AERRLSHEVC RKIELTDWEW CRSKSERTPR
QQRSTGGLSI PLCAFQGTVS LQAPTGKTLS LSTYEVSSDG LTISPNNAKK VEVYRSKSVG
HEPSADEAAS GGVAVGDTNV KIHLEVLEIC DNEEAMDSVS IISNISQSST HTRSPSLRYS
RRENRFVSCD LGETASYSLL IPGSSNPEVE SINISIPDTV EAHRQNSLRQ TRESLGYREE
IQLLNEAYMR QAEESKGI
//
