ID   H3CRU1_TETNG            Unreviewed;      1289 AA.
AC   H3CRU1;
DT   18-APR-2012, integrated into UniProtKB/TrEMBL.
DT   18-APR-2012, sequence version 1.
DT   27-MAR-2024, entry version 46.
DE   SubName: Full=5-oxoprolinase, ATP-hydrolysing {ECO:0000313|Ensembl:ENSTNIP00000010975.1};
OS   Tetraodon nigroviridis (Spotted green pufferfish) (Chelonodon
OS   nigroviridis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Tetraodon.
OX   NCBI_TaxID=99883 {ECO:0000313|Ensembl:ENSTNIP00000010975.1, ECO:0000313|Proteomes:UP000007303};
RN   [1] {ECO:0000313|Proteomes:UP000007303}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15496914; DOI=10.1038/nature03025;
RA   Jaillon O., Aury J.-M., Brunet F., Petit J.-L., Stange-Thomann N.,
RA   Mauceli E., Bouneau L., Fischer C., Ozouf-Costaz C., Bernot A., Nicaud S.,
RA   Jaffe D., Fisher S., Lutfalla G., Dossat C., Segurens B., Dasilva C.,
RA   Salanoubat M., Levy M., Boudet N., Castellano S., Anthouard V., Jubin C.,
RA   Castelli V., Katinka M., Vacherie B., Biemont C., Skalli Z., Cattolico L.,
RA   Poulain J., De Berardinis V., Cruaud C., Duprat S., Brottier P.,
RA   Coutanceau J.-P., Gouzy J., Parra G., Lardier G., Chapple C.,
RA   McKernan K.J., McEwan P., Bosak S., Kellis M., Volff J.-N., Guigo R.,
RA   Zody M.C., Mesirov J., Lindblad-Toh K., Birren B., Nusbaum C., Kahn D.,
RA   Robinson-Rechavi M., Laudet V., Schachter V., Quetier F., Saurin W.,
RA   Scarpelli C., Wincker P., Lander E.S., Weissenbach J., Roest Crollius H.;
RT   "Genome duplication in the teleost fish Tetraodon nigroviridis reveals the
RT   early vertebrate proto-karyotype.";
RL   Nature 431:946-957(2004).
RN   [2] {ECO:0000313|Ensembl:ENSTNIP00000010975.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the oxoprolinase family.
CC       {ECO:0000256|ARBA:ARBA00010403}.
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DR   STRING; 99883.ENSTNIP00000010975; -.
DR   Ensembl; ENSTNIT00000011157.1; ENSTNIP00000010975.1; ENSTNIG00000008149.1.
DR   GeneTree; ENSGT00390000013463; -.
DR   HOGENOM; CLU_002157_0_0_1; -.
DR   InParanoid; H3CRU1; -.
DR   OMA; TDCNVML; -.
DR   TreeFam; TF300520; -.
DR   Proteomes; UP000007303; Unassembled WGS sequence.
DR   GO; GO:0016787; F:hydrolase activity; IEA:InterPro.
DR   InterPro; IPR049517; ACX-like_C.
DR   InterPro; IPR008040; Hydant_A_N.
DR   InterPro; IPR002821; Hydantoinase_A.
DR   InterPro; IPR003692; Hydantoinase_B.
DR   InterPro; IPR045079; Oxoprolinase_fam.
DR   PANTHER; PTHR11365:SF2; 5-OXOPROLINASE; 1.
DR   PANTHER; PTHR11365; 5-OXOPROLINASE RELATED; 1.
DR   Pfam; PF19278; Hydant_A_C; 1.
DR   Pfam; PF05378; Hydant_A_N; 1.
DR   Pfam; PF01968; Hydantoinase_A; 1.
DR   Pfam; PF02538; Hydantoinase_B; 1.
PE   3: Inferred from homology;
KW   Reference proteome {ECO:0000313|Proteomes:UP000007303}.
FT   DOMAIN          10..207
FT                   /note="Hydantoinase/oxoprolinase N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF05378"
FT   DOMAIN          227..532
FT                   /note="Hydantoinase A/oxoprolinase"
FT                   /evidence="ECO:0000259|Pfam:PF01968"
FT   DOMAIN          542..711
FT                   /note="Acetophenone carboxylase-like C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF19278"
FT   DOMAIN          734..1255
FT                   /note="Hydantoinase B/oxoprolinase"
FT                   /evidence="ECO:0000259|Pfam:PF02538"
FT   REGION          1248..1267
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1289 AA;  139721 MW;  D4F6663841E22CBB CRC64;
     MAEARGKFDF AIDRGGTFTD VFARLPDGRE RVLKLLSRDP QNYKDAPTEG IRRVLEEETG
     RAFPRDQPVD TSLIGWIRMG TTVATNALLE REGERTALLV TRGFGDLLHI GTQARPKLFD
     LEVAVPEVLY EEVVEVDERV VLRRLTSPTS GSTGDSLEVW RELDLDKVEL DLRGVLSRGI
     TSVAVLLLHS YTWAEHERAV GALARRLGFT QVSLSSEVMP MVRAVPRGYT VCADAYLTPK
     IHQYLEGFTS GFKGGLKGVN VLFMQSDGGL TPMDQFCGSR AVLSGPAGGV VGYAITSYNQ
     MEKKPVIGFD MGGTSTDVSR YAGQYEHVFE ATTAGVTLQA PQLDINTVAA GGGSRLFFRS
     GMFVVGPESA GAHPGPACYR KGGPLTVTDA NLALGRLLPS FFPKIFGPEE NEPLSLEETL
     KHFQQLSQDI NLFLAVANGD NKSPDTARGM SVEEVAMGFI RVANEAMCRP IRALTQAKGH
     DTSQHVLACF GGAGGQHACA IARALGMKTV FIHKYSGVLS AYGLALADVV EEVQEPCSLQ
     YRQDSFAEID RRVEQLSGRC CEALRARGFS SAQLTTEVFL HLRYQGTDCA LMVSATGYPN
     NAQSCRAGDF QTAFTKRYLK EFGFTIPDRP IVVDDIRVRG CGKSGINSVS KSKTGHKQAK
     PVTKCYFEEG YLDTSVYLWE ELRCGQSIQG PAIIIDKNST ILVEPCCEAR LTEGGDVCVT
     VGSDRQRVLG TELDTVQLSI FSHRFMSIAE QMGRVLQRTS ISTNIKERLD FSCAVFGPDG
     GLVSNAPHIP VHLGAMQETV QYQIKTLGNK LKEGDVILSN HPCAGGSHLP DLTVITPVFQ
     KGVGSPVFFV ASRGHHADIG GITPGSMPPH STSLQQEGAV FTSFKLVTGG VFQEAAVSEA
     LMAPAQYPGC SGTRNLHDNL SDLRAQVAAN QRGSQLVGEL IDCYGLAVVQ AYMGYIQSNA
     ELAVRDMLRE FARRRRQQTG SLEVESEDFM DDGTPIRLRV QINEEEGSAV FDFSGTGTEV
     WGNCNAPRAI TLSALIYCLR CMVGQDIPLN QGCLAPIKVV IPPGSILQPS QNAAVVGGNV
     LTSQRVVDVI FRAFEVCAAS QGCMNNISFG NDSVGYYETV AGGAGAGPGW DGRSGVHSHM
     TNTRITDPEI LEKRYPVILE RFSLRPGSGG RGKHRGGDGV IRKLLFRSNV VLSVLTERRS
     TRPYGLKGAE DGAAGLNLLH RADGQVLNLG AKNSISLQPG DMFCLYTPGG GGYGQEDDDQ
     RPRTKRRRLN ETFPERGSVF EYRMAQEGV
//