ID H3CSQ8_TETNG Unreviewed; 339 AA.
AC H3CSQ8;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 1.
DT 27-MAR-2024, entry version 48.
DE RecName: Full=Snurportin-1 {ECO:0000256|ARBA:ARBA00016034};
DE AltName: Full=RNA U transporter 1 {ECO:0000256|ARBA:ARBA00031454};
OS Tetraodon nigroviridis (Spotted green pufferfish) (Chelonodon
OS nigroviridis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Tetraodon.
OX NCBI_TaxID=99883 {ECO:0000313|Ensembl:ENSTNIP00000011292.1, ECO:0000313|Proteomes:UP000007303};
RN [1] {ECO:0000313|Proteomes:UP000007303}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15496914; DOI=10.1038/nature03025;
RA Jaillon O., Aury J.-M., Brunet F., Petit J.-L., Stange-Thomann N.,
RA Mauceli E., Bouneau L., Fischer C., Ozouf-Costaz C., Bernot A., Nicaud S.,
RA Jaffe D., Fisher S., Lutfalla G., Dossat C., Segurens B., Dasilva C.,
RA Salanoubat M., Levy M., Boudet N., Castellano S., Anthouard V., Jubin C.,
RA Castelli V., Katinka M., Vacherie B., Biemont C., Skalli Z., Cattolico L.,
RA Poulain J., De Berardinis V., Cruaud C., Duprat S., Brottier P.,
RA Coutanceau J.-P., Gouzy J., Parra G., Lardier G., Chapple C.,
RA McKernan K.J., McEwan P., Bosak S., Kellis M., Volff J.-N., Guigo R.,
RA Zody M.C., Mesirov J., Lindblad-Toh K., Birren B., Nusbaum C., Kahn D.,
RA Robinson-Rechavi M., Laudet V., Schachter V., Quetier F., Saurin W.,
RA Scarpelli C., Wincker P., Lander E.S., Weissenbach J., Roest Crollius H.;
RT "Genome duplication in the teleost fish Tetraodon nigroviridis reveals the
RT early vertebrate proto-karyotype.";
RL Nature 431:946-957(2004).
RN [2] {ECO:0000313|Ensembl:ENSTNIP00000011292.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Functions as an U snRNP-specific nuclear import adapter.
CC Involved in the trimethylguanosine (m3G)-cap-dependent nuclear import
CC of U snRNPs. Binds specifically to the terminal m3G-cap U snRNAs.
CC {ECO:0000256|ARBA:ARBA00003975}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the snurportin family.
CC {ECO:0000256|ARBA:ARBA00007540}.
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DR AlphaFoldDB; H3CSQ8; -.
DR STRING; 99883.ENSTNIP00000011292; -.
DR Ensembl; ENSTNIT00000011474.1; ENSTNIP00000011292.1; ENSTNIG00000008456.1.
DR GeneTree; ENSGT00510000047494; -.
DR HOGENOM; CLU_056809_0_0_1; -.
DR InParanoid; H3CSQ8; -.
DR OMA; VQLSEWM; -.
DR TreeFam; TF313108; -.
DR Proteomes; UP000007303; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0061608; F:nuclear import signal receptor activity; IEA:InterPro.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR GO; GO:0006606; P:protein import into nucleus; IEA:InterPro.
DR GO; GO:0061015; P:snRNA import into nucleus; IEA:InterPro.
DR CDD; cd09232; Snurportin-1_C; 1.
DR Gene3D; 3.30.470.30; DNA ligase/mRNA capping enzyme; 1.
DR InterPro; IPR002652; Importin-a_IBB.
DR InterPro; IPR017336; Snurportin-1.
DR InterPro; IPR024721; Snurportin-1_N.
DR InterPro; IPR047857; Snurportin1_C.
DR PANTHER; PTHR13403:SF6; SNURPORTIN-1; 1.
DR PANTHER; PTHR13403; SNURPORTIN1 RNUT1 PROTEIN RNA, U TRANSPORTER 1; 1.
DR Pfam; PF11538; Snurportin1; 1.
DR SUPFAM; SSF56091; DNA ligase/mRNA capping enzyme, catalytic domain; 1.
DR PROSITE; PS51214; IBB; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000007303};
KW RNA-binding {ECO:0000256|ARBA:ARBA00022884};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|PROSITE-
KW ProRule:PRU00561}.
FT DOMAIN 11..73
FT /note="IBB"
FT /evidence="ECO:0000259|PROSITE:PS51214"
FT REGION 67..88
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 317..339
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 73..88
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 339 AA; 38742 MW; 4AF347FEAD11E199 CRC64;
MDDLTEALSA SFAVSKEHNS TAAPHPRLAQ YKCKYSALEQ SERRRHFLEL QKSKRLNYVN
HARRLANGDW AGTDSDGEED LENQQEEEEE MDVEIKLPKD YANQLMLSEW LVDVPAELDT
DWLMVVCPVG EKIPHCGLQD QLTAASLIVT PFMHPTGAPY SRMLTVLCKL CADYTILDCI
YSEVNRTYYI LDVMCWRGHP VYDCPTDFRF YWLQSKVQEA DGLSEIAKRN PFRFVSLHSA
DCTVESIQKA LAAKYDFDVD GILFYHRQTH YTPGSTPLVG WLRPYMVSDI LDMEVPEGPL
TAKPQYANHQ MQQILEHKKP SSQVRPANAS GGYELEHLS
//
