ID H3CSZ3_TETNG Unreviewed; 2332 AA.
AC H3CSZ3;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 1.
DT 27-MAR-2024, entry version 66.
DE RecName: Full=Nuclear receptor corepressor 1 {ECO:0000256|ARBA:ARBA00044171};
OS Tetraodon nigroviridis (Spotted green pufferfish) (Chelonodon
OS nigroviridis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Tetraodon.
OX NCBI_TaxID=99883 {ECO:0000313|Ensembl:ENSTNIP00000011377.1, ECO:0000313|Proteomes:UP000007303};
RN [1] {ECO:0000313|Proteomes:UP000007303}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15496914; DOI=10.1038/nature03025;
RA Jaillon O., Aury J.-M., Brunet F., Petit J.-L., Stange-Thomann N.,
RA Mauceli E., Bouneau L., Fischer C., Ozouf-Costaz C., Bernot A., Nicaud S.,
RA Jaffe D., Fisher S., Lutfalla G., Dossat C., Segurens B., Dasilva C.,
RA Salanoubat M., Levy M., Boudet N., Castellano S., Anthouard V., Jubin C.,
RA Castelli V., Katinka M., Vacherie B., Biemont C., Skalli Z., Cattolico L.,
RA Poulain J., De Berardinis V., Cruaud C., Duprat S., Brottier P.,
RA Coutanceau J.-P., Gouzy J., Parra G., Lardier G., Chapple C.,
RA McKernan K.J., McEwan P., Bosak S., Kellis M., Volff J.-N., Guigo R.,
RA Zody M.C., Mesirov J., Lindblad-Toh K., Birren B., Nusbaum C., Kahn D.,
RA Robinson-Rechavi M., Laudet V., Schachter V., Quetier F., Saurin W.,
RA Scarpelli C., Wincker P., Lander E.S., Weissenbach J., Roest Crollius H.;
RT "Genome duplication in the teleost fish Tetraodon nigroviridis reveals the
RT early vertebrate proto-karyotype.";
RL Nature 431:946-957(2004).
RN [2] {ECO:0000313|Ensembl:ENSTNIP00000011377.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the N-CoR nuclear receptor corepressors family.
CC {ECO:0000256|ARBA:ARBA00010097}.
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DR STRING; 99883.ENSTNIP00000011377; -.
DR Ensembl; ENSTNIT00000011559.1; ENSTNIP00000011377.1; ENSTNIG00000008537.1.
DR GeneTree; ENSGT00940000155093; -.
DR InParanoid; H3CSZ3; -.
DR OMA; AVIPPMX; -.
DR TreeFam; TF106423; -.
DR Proteomes; UP000007303; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProt.
DR CDD; cd00167; SANT; 2.
DR Gene3D; 1.20.5.430; -; 1.
DR Gene3D; 1.20.58.1880; -; 1.
DR Gene3D; 1.10.10.60; Homeodomain-like; 1.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR017930; Myb_dom.
DR InterPro; IPR031557; N-CoR_GPS2_interact.
DR InterPro; IPR001005; SANT/Myb.
DR InterPro; IPR017884; SANT_dom.
DR PANTHER; PTHR13992; NUCLEAR RECEPTOR CO-REPRESSOR RELATED NCOR; 1.
DR PANTHER; PTHR13992:SF5; NUCLEAR RECEPTOR COREPRESSOR 1; 1.
DR Pfam; PF15784; GPS2_interact; 1.
DR Pfam; PF00249; Myb_DNA-binding; 2.
DR SMART; SM00717; SANT; 2.
DR SUPFAM; SSF46689; Homeodomain-like; 2.
DR PROSITE; PS51294; HTH_MYB; 1.
DR PROSITE; PS50090; MYB_LIKE; 1.
DR PROSITE; PS51293; SANT; 2.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Reference proteome {ECO:0000313|Proteomes:UP000007303};
KW Repressor {ECO:0000256|ARBA:ARBA00022491};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT DOMAIN 428..479
FT /note="SANT"
FT /evidence="ECO:0000259|PROSITE:PS51293"
FT DOMAIN 608..658
FT /note="Myb-like"
FT /evidence="ECO:0000259|PROSITE:PS50090"
FT DOMAIN 611..662
FT /note="SANT"
FT /evidence="ECO:0000259|PROSITE:PS51293"
FT DOMAIN 615..662
FT /note="HTH myb-type"
FT /evidence="ECO:0000259|PROSITE:PS51294"
FT REGION 1..81
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 142..170
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 203..222
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 538..618
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 671..843
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 918..952
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1288..1307
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1381..1459
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1752..1816
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1849..1942
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1962..2085
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2189..2280
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..47
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 538..559
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 596..612
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 690..708
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 709..725
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 733..747
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 759..775
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 793..834
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 918..937
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1381..1403
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1420..1437
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1752..1781
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1859..1875
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1887..1942
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1962..2017
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2021..2038
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2062..2076
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2332 AA; 258999 MW; 3B8C2AF420AE0692 CRC64;
MSSSSGYPHS QGTFSNEQNR YPPHSVQYTF TSTRHPQDYT SPDYRTHIQD PQGRRRPSLL
SEFHPGTERP PERRHGYEQQ FHSIAAQSEH EALEAKRPRM ETVAEAHITR TPPTAGGIVL
PITHTVQDSL RATVEVKKES QFTVKVESPS PGGHSLHIGE DQDTSPSKLS KEELIQSMDR
VDREIAKVEQ QILKLKKKQQ QLEEEAAKPV EPEKPVTPPP VEHKHRSIVQ IIYDENRKKA
EEAHKILEGL GPKVELPLYN QPSDTKVYHD NIKTNQVMRK KLILFFKRRN HARKQREQKI
CQRYDQLMEA WEKKVERMEN NPRRKAKESR TREYYERQFP EIRKQREQQE RFQRVGQRGT
GLSATIARSE HEISEIIDGL SEQENNEKQM RQLSVIPPMM YDSEQRRVKF INMNGLMDDP
MKVYKARQFM NVWTEHEKEI FKEKFVQHPK NFGLIASYLE RKCVADCVLY YYLTKKNNNY
KTLVRRNYGK RRGRNQQITR PSSRSVVFLS DQFLELEIVN CKDYFSCAGS KITMDISKDK
DKCDGGEDEE GKEHNTPRGR KTANSQGRRK GRITTRSMAN EAASVAADEA PSAATDSLTD
PPQLTAAGET GETSRWTEEE MEVAKKGLVE HGRNWTAIAK MVGTKSEAQC KNFYFNYKRR
HNLDNLLQQH KQDTRRARAD RSQGEGQATA SPDDDDEDNA DDSEGGDNSS DTESAPSPSQ
ADSSKSADSK RSESAAGDSQ CSDQDRCQAG SGKAPEPSYT ELRVKEEKSP EDEMQSQEAK
VASFSGSIRP KTEPQDMDMK VGEVQVKMEP EVKERGEKAE HGGREHHSDN DSSATCSADE
DIEAEPERRF CRILVEKPSL LNPPGSVLVS SPKQAQLNIQ QLQQRAAAIP PMVPGHFGPG
GVPISGFAML QHQIKAVHES AHQEEKQRQD QGDLERRPPF NSRSPTIIDR DGMRTKAVLH
PVSSQLVQGI PDGVRVTFSR PSRPANIPSP PPLIPTTKPT DKPSFIQGGS ISQGTPGTYL
PPHAVYGPEG SKSTVGSISL GLPRQQDLNK SGTTTLYKYK IQLTKSGKKK PETLMPNPSV
STYWWKQMGQ NCSSSDSRGN PAKVGETLAF RGSITQGTPA LSQSSLAADL LKGTITKLAT
EDLTSSDKTR GEQMAKGHVI YEGKSGHIVS YDAIKNSREN TLKRTYDMIE GPMSRTHSGR
DGAQFEGLIS RALPRDGLHG DSKERPLITG SIMQGTPRTT AESYEEALKY GKQIKRESPP
IRSFEGGISK GKPYEGVNTI KELGRSIHEI PRQDPSGQDL RKTPELSDRR AMESSLSQFV
SFKFQIHSLN QPTIKHNVKS LITSPSKLPH SMPQLEAMER VKYEDSKPVR HTSVVNSTAS
VLRSTHQEGH LVNYSTNPVS RGSPMLGRAS EEGSSKSSAH ERKSTMTPTQ RESVPAKSPV
SGSDPVASHS PFDPHHRPVV PGEVYRAHLS PHLDPTLAYH RVLDPAFMFP RQPSPTGYHN
TYQLYTMENT RQTILNDYIT SQQMQVIPRP DMARGLSPRE QPVTIPYAPG ARVKGIIDLA
QMPPTILLPH PGGTGTPTLE RIAYLPGAQP PFPPRGFTQP PYHQVRIPPR HPAHLVAAAA
AVASAERERE REQQETNEYI RGGKESFYKF TNSYRAQRGV PEQPGRPVSR GYLHSPSPSL
RTQEVVVQQR PSIFQGKSVI TSLMYAFCLC LKPSSAAATA AAQSSSRYST AADALAALVD
AAASAPQMDV AKVKENKHDR EEDLSVRRTT ALSEHQQQEA ERRSMQSPYG AMSLPVGKPH
TPYAEGPGNK DKALQTSKSR IEEELRTRGK TTITAANFID VIITRQIASD KDSRERGSQS
SDSSSSLSSN RYDNTGGGAI EVISPAGSPV QPQQDKPEEG QQQTAGMRAY DTSRYRTPGE
PTQQTSAQQP PSSQPDSYSQ VPKTHRVMTL ADHISHIITQ DFARNQDPTP VPSTASATFQ
TVMPPASSSG RVKVPSRYSP ENQGQGPHHQ RPSSRVSPEN APDKPRARPG RSPDRGGRVM
DNYEPISPPH TYQGMDKQDP GGPASQRREA ESDIRTDSRS PGSVSYLPSF FTKLENTSPM
VKSKKQEIFR KLNSTTGVKD SDVGNAQPGT EIFNLPAVTS SSVINPRNQS FNDPANNLGL
EDIIRKALMG NLEERQEDHQ GGVAAQCTIN NSSATGGDSR QEMNSSPSMG RRSQNTGKQK
QGKTTSRKSK SPNLGQAYSA GERPSSVSSV HSEGDYHRQA QAQAQWSWDD RPSSTGSMQF
PYNPLTMRIL NNTPPTSIAS PAIHPAAAPV GQQRVWKSLL SEKYETLSDS DD
//
