ID H3CT55_TETNG Unreviewed; 950 AA.
AC H3CT55;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 1.
DT 27-MAR-2024, entry version 61.
DE RecName: Full=Hypoxia up-regulated protein 1 {ECO:0000256|ARBA:ARBA00040503};
OS Tetraodon nigroviridis (Spotted green pufferfish) (Chelonodon
OS nigroviridis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Tetraodon.
OX NCBI_TaxID=99883 {ECO:0000313|Ensembl:ENSTNIP00000011439.1, ECO:0000313|Proteomes:UP000007303};
RN [1] {ECO:0000313|Proteomes:UP000007303}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15496914; DOI=10.1038/nature03025;
RA Jaillon O., Aury J.-M., Brunet F., Petit J.-L., Stange-Thomann N.,
RA Mauceli E., Bouneau L., Fischer C., Ozouf-Costaz C., Bernot A., Nicaud S.,
RA Jaffe D., Fisher S., Lutfalla G., Dossat C., Segurens B., Dasilva C.,
RA Salanoubat M., Levy M., Boudet N., Castellano S., Anthouard V., Jubin C.,
RA Castelli V., Katinka M., Vacherie B., Biemont C., Skalli Z., Cattolico L.,
RA Poulain J., De Berardinis V., Cruaud C., Duprat S., Brottier P.,
RA Coutanceau J.-P., Gouzy J., Parra G., Lardier G., Chapple C.,
RA McKernan K.J., McEwan P., Bosak S., Kellis M., Volff J.-N., Guigo R.,
RA Zody M.C., Mesirov J., Lindblad-Toh K., Birren B., Nusbaum C., Kahn D.,
RA Robinson-Rechavi M., Laudet V., Schachter V., Quetier F., Saurin W.,
RA Scarpelli C., Wincker P., Lander E.S., Weissenbach J., Roest Crollius H.;
RT "Genome duplication in the teleost fish Tetraodon nigroviridis reveals the
RT early vertebrate proto-karyotype.";
RL Nature 431:946-957(2004).
RN [2] {ECO:0000313|Ensembl:ENSTNIP00000011439.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Has a pivotal role in cytoprotective cellular mechanisms
CC triggered by oxygen deprivation. May play a role as a molecular
CC chaperone and participate in protein folding.
CC {ECO:0000256|ARBA:ARBA00037692}.
CC -!- SIMILARITY: Belongs to the heat shock protein 70 family.
CC {ECO:0000256|ARBA:ARBA00007381}.
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DR AlphaFoldDB; H3CT55; -.
DR STRING; 99883.ENSTNIP00000011439; -.
DR Ensembl; ENSTNIT00000011621.1; ENSTNIP00000011439.1; ENSTNIG00000008598.1.
DR GeneTree; ENSGT00940000157686; -.
DR HOGENOM; CLU_005965_5_0_1; -.
DR InParanoid; H3CT55; -.
DR OMA; SRTPMIQ; -.
DR TreeFam; TF105048; -.
DR Proteomes; UP000007303; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0140662; F:ATP-dependent protein folding chaperone; IEA:InterPro.
DR CDD; cd10230; HYOU1-like_NBD; 1.
DR Gene3D; 1.20.1270.10; -; 1.
DR Gene3D; 3.30.30.30; -; 1.
DR Gene3D; 3.30.420.40; -; 2.
DR InterPro; IPR043129; ATPase_NBD.
DR InterPro; IPR018181; Heat_shock_70_CS.
DR InterPro; IPR029048; HSP70_C_sf.
DR InterPro; IPR029047; HSP70_peptide-bd_sf.
DR InterPro; IPR013126; Hsp_70_fam.
DR PANTHER; PTHR45639; HSC70CB, ISOFORM G-RELATED; 1.
DR PANTHER; PTHR45639:SF3; HYPOXIA UP-REGULATED PROTEIN 1; 1.
DR Pfam; PF00012; HSP70; 1.
DR PRINTS; PR00301; HEATSHOCK70.
DR SUPFAM; SSF53067; Actin-like ATPase domain; 2.
DR SUPFAM; SSF100934; Heat shock protein 70kD (HSP70), C-terminal subdomain; 1.
DR PROSITE; PS00329; HSP70_2; 1.
DR PROSITE; PS01036; HSP70_3; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000007303};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..22
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 23..950
FT /note="Hypoxia up-regulated protein 1"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5003581201"
FT REGION 562..630
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 896..950
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 569..591
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 607..623
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 904..925
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 950 AA; 106458 MW; D6992E0B5B787C66 CRC64;
FSQLIMEGRK LALVAIFSLV LSSLPSHTVS VAVMSVDLGS EWMKMAIVKP GVPMEIVLNK
ESRRKTPTAV CLKENERLFG DSALGMSVKN PRSVYLHLQS LLGKKHGNLQ VALYQKRFPE
HQLQEDSVRG TAYFKYSQEM QYTAEELLGM VLNYSRVLAQ DFAEQPIKDA VITVPAFFNQ
AERRAVLQAA QLAGLKVLQL INDNTAVALN YGVFRRKDID STAKNVMFYD MGSGSTTATI
VTYQTVKTKE SGTQPQLQIR GVGFDRGLGG FEMDLRLRDH LAKLFNGQKK SGKDVRENHR
AMAKLLKEAQ RLKTVLSANV DFMAQVEGLM DDIDFKAKVT RAEFEDLCAD LFERVPQPVR
DALSTAEMTM SEIEQVILVG GSTRVPKVQE VLLKAVGKEE LGKNINADEA AAMGAVYQAA
ALSKAFKVKP FLVRDAAVFP IQVDFTRETE EEGTKTVKHN KRILFDRMAP YPQRKVITFN
RYNADFAFDI NYGDLSFLSK EDISVFGSLN LTTVKLSGVG SSFQKHADAE SKGIKAHFNM
DESGVLLLDR VESVFETMEE EKEEESTLTK LGNTISTLFG GGSSEPTPNV TEPVQDEEEV
PPESGTEDEA EEKTQKPEET GSKTNPKVRG VVSAGRSVAL KRQTWRRFYA LLVKGEQDNK
TSGEADAERK AKPKKKSKIS EDIAVELLIN DVLDPTPEEL TSSKKKLQDL TDRDMAKHER
EKTLNSLEAF IFETQDKLYQ EEYQFVVSEE EKEQISGKLR DASEWMDEDG YAATTKQLRE
KLSQLKSSCK DMFFRVEERR KWPEHLAALE SMLNTSSFFL RSAKLIPEDD QIFTEVELNL
LEKVINETTT WKNETVAEQE KRSPQERPIL LSKDIESKLA LLDREVNYLL NKAKFAKPKA
KAKAKNSTSA DKDNSTSEEK TIPPAEQEKA PPPTVADTEA KSDSFPGPTE
//
