ID H3CT91_TETNG Unreviewed; 1930 AA.
AC H3CT91;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 1.
DT 27-MAR-2024, entry version 75.
DE SubName: Full=Discs, large homolog 5a (Drosophila) {ECO:0000313|Ensembl:ENSTNIP00000011475.1};
OS Tetraodon nigroviridis (Spotted green pufferfish) (Chelonodon
OS nigroviridis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Tetraodon.
OX NCBI_TaxID=99883 {ECO:0000313|Ensembl:ENSTNIP00000011475.1, ECO:0000313|Proteomes:UP000007303};
RN [1] {ECO:0000313|Proteomes:UP000007303}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15496914; DOI=10.1038/nature03025;
RA Jaillon O., Aury J.-M., Brunet F., Petit J.-L., Stange-Thomann N.,
RA Mauceli E., Bouneau L., Fischer C., Ozouf-Costaz C., Bernot A., Nicaud S.,
RA Jaffe D., Fisher S., Lutfalla G., Dossat C., Segurens B., Dasilva C.,
RA Salanoubat M., Levy M., Boudet N., Castellano S., Anthouard V., Jubin C.,
RA Castelli V., Katinka M., Vacherie B., Biemont C., Skalli Z., Cattolico L.,
RA Poulain J., De Berardinis V., Cruaud C., Duprat S., Brottier P.,
RA Coutanceau J.-P., Gouzy J., Parra G., Lardier G., Chapple C.,
RA McKernan K.J., McEwan P., Bosak S., Kellis M., Volff J.-N., Guigo R.,
RA Zody M.C., Mesirov J., Lindblad-Toh K., Birren B., Nusbaum C., Kahn D.,
RA Robinson-Rechavi M., Laudet V., Schachter V., Quetier F., Saurin W.,
RA Scarpelli C., Wincker P., Lander E.S., Weissenbach J., Roest Crollius H.;
RT "Genome duplication in the teleost fish Tetraodon nigroviridis reveals the
RT early vertebrate proto-karyotype.";
RL Nature 431:946-957(2004).
RN [2] {ECO:0000313|Ensembl:ENSTNIP00000011475.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR STRING; 99883.ENSTNIP00000011475; -.
DR Ensembl; ENSTNIT00000011657.1; ENSTNIP00000011475.1; ENSTNIG00000008629.1.
DR GeneTree; ENSGT00940000155303; -.
DR HOGENOM; CLU_002448_1_0_1; -.
DR InParanoid; H3CT91; -.
DR OMA; PCETITI; -.
DR TreeFam; TF323171; -.
DR Proteomes; UP000007303; Unassembled WGS sequence.
DR GO; GO:0042981; P:regulation of apoptotic process; IEA:InterPro.
DR CDD; cd01671; CARD; 1.
DR CDD; cd00992; PDZ_signaling; 4.
DR CDD; cd11860; SH3_DLG5; 1.
DR Gene3D; 2.30.42.10; -; 4.
DR Gene3D; 1.10.533.10; Death Domain, Fas; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR001315; CARD.
DR InterPro; IPR011029; DEATH-like_dom_sf.
DR InterPro; IPR006907; DLG5_N.
DR InterPro; IPR035537; DLG5_SH3.
DR InterPro; IPR008145; GK/Ca_channel_bsu.
DR InterPro; IPR008144; Guanylate_kin-like_dom.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR001478; PDZ.
DR InterPro; IPR036034; PDZ_sf.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR46360; DISKS LARGE HOMOLOG 5; 1.
DR PANTHER; PTHR46360:SF1; DISKS LARGE HOMOLOG 5; 1.
DR Pfam; PF16610; dbPDZ_assoc; 1.
DR Pfam; PF00625; Guanylate_kin; 1.
DR Pfam; PF00595; PDZ; 4.
DR Pfam; PF04822; Takusan; 1.
DR SMART; SM00072; GuKc; 1.
DR SMART; SM00228; PDZ; 4.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF47986; DEATH domain; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF50156; PDZ domain-like; 4.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS50209; CARD; 1.
DR PROSITE; PS50052; GUANYLATE_KINASE_2; 1.
DR PROSITE; PS50106; PDZ; 4.
DR PROSITE; PS50002; SH3; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000007303};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 1..92
FT /note="CARD"
FT /evidence="ECO:0000259|PROSITE:PS50209"
FT DOMAIN 626..716
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 711..802
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 1357..1436
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 1515..1595
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 1606..1674
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 1786..1916
FT /note="Guanylate kinase-like"
FT /evidence="ECO:0000259|PROSITE:PS50052"
FT REGION 93..149
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 817..839
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 979..1081
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1094..1119
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1214..1310
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1441..1512
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 151..419
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 445..602
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 96..138
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 818..837
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 998..1021
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1094..1113
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1214..1273
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1291..1310
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1441..1464
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1471..1498
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1930 AA; 215505 MW; 7F48CF8AEB32DD6C CRC64;
MEPKHKELLD QCHQNLLESI TDADRVIELL IVSGTLSQLE RFELDQNCSS SAEKVDHLLK
MLMSKESDHF LDLCVALEKA YPDLHAALFG NNGGGPVDHN TDTGSTYSVL STMPSDSESS
SSLSSVGSPV NGEASSPPPA INDNRPAGDN LDTILFQLRQ VTRERDELRK RLALASPGTT
FDDCRPNSKA SHDYERLKSQ CMRAMADLQS LQNQHTKTLK RCEEAVKEAD FYHMLHSRVL
GEQTQLKEEM EALRRDNAQL VREHNHLKQS CEELKRLHGQ DQAELADLRL QQQQVMREKG
SSEVLNKLYD TAMDKLEGVK KDYDALSKRY SEKVASHNTD LSRLEQAEEE TRRLQKQVDA
LLKQRDSAIQ YQQQCSTSMR RFDSVQQELN KFSSQNKELQ REMERLQSEV TRYKNLQLKS
AKDCEKYKEE RDSVFNEYRL IMSERDQVIK EVDKLQTELE SAEARLKNTS SERVVASEEL
EALRQKQDTA TLDMERANKE IEVLRKQYEA MSQELKEATQ EAEVAKCRRD WAFQERDKIV
AERESIRTLC DNLRRERDRA VSDLADALRN LDDMRKQKND ALRELKEIKE KMESQLEKEA
RFCQLMAHSS HDSAIDTDSL EWETEVVEFE KDRDDMDLKA LGFDIAEGVN DPYLPGDCGI
FVTRVDKGSV ADGRLRVNDW LLKINDIDVT NKDRKQVVKA VLNGGGLINM VVRRRKSLGG
RLVTPVHINL MGHKDSGIGL ENGVFITAIV QGSPAAREGS LTAGDRLIAI NGIALDNKSV
TECEALLRSC RDTLSLSLMK FFPHSTSGQN IFESLRESSE KSNGRIHLSD LHSRNSRNLR
HNSSTQTDIF CTDAGSSTTG SIAGDRRKGR GESEEMYKPF STGSLHATGL RPTSELGAGR
YGPSAFQECC PYTKAPSSLP FEPVTTSECV TMETALEKKH SGGTWPKMMV GGMSVAPENT
GAIAAAQLSI YKSPKQRKSI FDPDTFKRPE TPSSKMDAAS AAAVSHSPQP SKTDSLSSSS
TPTPTPPTPP TRSDSFKFKH KHQSSSASDC TVTSDSKGEA AVATAAGESR ERSERDRNGN
HYFLDGKVLT SRKSCDEDIG RTRGEEPEVK RPRPKSAPAL AGRVTPQTVT LPTFQAQRRL
CPHRLQWHPT SHLKPWRSRP FLTWPRALPD SAHRGLSPCP AVTAVMRNPV YTVRSHRVHT
SNCPSVASQI CHQHTHSSPQ HQGRLSLDLS QQKCPNDYSE STSSRSSRAS HGTNSLPSSA
RLGSSSIVQY RTERIKIPST PRYPRSMLGS DRGSLSHSEC SSPSLITPPQ SPLNLETSSF
ASSQSQGSIS TLPRISVSPV PIAERRKDRP YLEEPRNVVV HKGAEPLGIS IVSGENGGIF
VSKVTGGSIA HQAGLEYGDQ LLEYNGINLR NATEQQARLI IGQQCDTITI MAQYNPHMYQ
LGNHSRSSSR LEPVSTTPQG SGAATPESHP VIDTLSEQDE GTLTPSSKQT TPTTSPRSLL
RMPADGGRKA GEPRLVVVHR PGVEVGVTLC GGNLRGVYIE SVDEDSPARS PDGLLPGDLI
LEYNSVSMKN KTAEEVYVEM LKPAETVTLK VQHRPDDFSV MKDLPGDGFY IRALYERVGE
ADGDLSFKKD DILFVDESLP KGSFGTWMAW QLDENAQKIQ RGQIPSKYMM DQEFYRRHSV
TEMKEDSGKS LSAAARRSFF RRKQKHKRSS SKDSKEMVAL DAISTDSIPF LDDCVSLAYQ
RVQKVECISP RPVLVLGPLT DAVKEMLVKE SPGKYCRCLL EMMKASQQAI ERGVKDCLFI
DFKRRSGHFD VTTVASIKEM TEKGCHCLLD IGPHAIERLH SVHIYPIVVF VRYKNAKQIK
EQKDPVYLRD KVSQKHSKEQ FENAQKIEQE YSKFFTGIVQ GGSLPYICTQ IMTIVDQEQS
KVLWTPLGCP
//
