ID H3CTB7_TETNG Unreviewed; 2000 AA.
AC H3CTB7;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 1.
DT 27-MAR-2024, entry version 62.
DE SubName: Full=Myoferlin like {ECO:0000313|Ensembl:ENSTNIP00000011501.1};
GN Name=MYOF {ECO:0000313|Ensembl:ENSTNIP00000011501.1};
OS Tetraodon nigroviridis (Spotted green pufferfish) (Chelonodon
OS nigroviridis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Tetraodon.
OX NCBI_TaxID=99883 {ECO:0000313|Ensembl:ENSTNIP00000011501.1, ECO:0000313|Proteomes:UP000007303};
RN [1] {ECO:0000313|Proteomes:UP000007303}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15496914; DOI=10.1038/nature03025;
RA Jaillon O., Aury J.-M., Brunet F., Petit J.-L., Stange-Thomann N.,
RA Mauceli E., Bouneau L., Fischer C., Ozouf-Costaz C., Bernot A., Nicaud S.,
RA Jaffe D., Fisher S., Lutfalla G., Dossat C., Segurens B., Dasilva C.,
RA Salanoubat M., Levy M., Boudet N., Castellano S., Anthouard V., Jubin C.,
RA Castelli V., Katinka M., Vacherie B., Biemont C., Skalli Z., Cattolico L.,
RA Poulain J., De Berardinis V., Cruaud C., Duprat S., Brottier P.,
RA Coutanceau J.-P., Gouzy J., Parra G., Lardier G., Chapple C.,
RA McKernan K.J., McEwan P., Bosak S., Kellis M., Volff J.-N., Guigo R.,
RA Zody M.C., Mesirov J., Lindblad-Toh K., Birren B., Nusbaum C., Kahn D.,
RA Robinson-Rechavi M., Laudet V., Schachter V., Quetier F., Saurin W.,
RA Scarpelli C., Wincker P., Lander E.S., Weissenbach J., Roest Crollius H.;
RT "Genome duplication in the teleost fish Tetraodon nigroviridis reveals the
RT early vertebrate proto-karyotype.";
RL Nature 431:946-957(2004).
RN [2] {ECO:0000313|Ensembl:ENSTNIP00000011501.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasmic vesicle membrane
CC {ECO:0000256|ARBA:ARBA00004483}; Single-pass type II membrane protein
CC {ECO:0000256|ARBA:ARBA00004483}. Membrane
CC {ECO:0000256|ARBA:ARBA00004606}; Single-pass type II membrane protein
CC {ECO:0000256|ARBA:ARBA00004606}.
CC -!- SIMILARITY: Belongs to the ferlin family.
CC {ECO:0000256|ARBA:ARBA00007561}.
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DR STRING; 99883.ENSTNIP00000011501; -.
DR Ensembl; ENSTNIT00000011683.1; ENSTNIP00000011501.1; ENSTNIG00000008653.1.
DR GeneTree; ENSGT00940000154741; -.
DR HOGENOM; CLU_001183_2_1_1; -.
DR InParanoid; H3CTB7; -.
DR OMA; GPPCVIT; -.
DR TreeFam; TF316871; -.
DR Proteomes; UP000007303; Unassembled WGS sequence.
DR GO; GO:0030659; C:cytoplasmic vesicle membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR CDD; cd08373; C2A_Ferlin; 1.
DR CDD; cd04011; C2B_Ferlin; 1.
DR CDD; cd04018; C2C_Ferlin; 1.
DR CDD; cd04017; C2D_Ferlin; 1.
DR CDD; cd04037; C2E_Ferlin; 1.
DR CDD; cd08374; C2F_Ferlin; 1.
DR Gene3D; 2.60.40.150; C2 domain; 5.
DR InterPro; IPR000008; C2_dom.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR037726; C2A_Ferlin.
DR InterPro; IPR037720; C2B_Ferlin.
DR InterPro; IPR037722; C2C_Ferlin.
DR InterPro; IPR037723; C2D_Ferlin.
DR InterPro; IPR037724; C2E_Ferlin.
DR InterPro; IPR037725; C2F_Ferlin.
DR InterPro; IPR012968; FerIin_dom.
DR InterPro; IPR037721; Ferlin.
DR InterPro; IPR012560; Ferlin_A-domain.
DR InterPro; IPR012561; Ferlin_B-domain.
DR InterPro; IPR032362; Ferlin_C.
DR InterPro; IPR006614; Peroxin/Ferlin.
DR PANTHER; PTHR12546; FER-1-LIKE; 1.
DR PANTHER; PTHR12546:SF55; MYOFERLIN; 1.
DR Pfam; PF00168; C2; 7.
DR Pfam; PF08165; FerA; 1.
DR Pfam; PF08150; FerB; 1.
DR Pfam; PF08151; FerI; 1.
DR Pfam; PF16165; Ferlin_C; 1.
DR SMART; SM00239; C2; 6.
DR SMART; SM00694; DysFC; 2.
DR SMART; SM00693; DysFN; 2.
DR SMART; SM01200; FerA; 1.
DR SMART; SM01201; FerB; 1.
DR SMART; SM01202; FerI; 1.
DR SUPFAM; SSF49562; C2 domain (Calcium/lipid-binding domain, CaLB); 7.
DR PROSITE; PS50004; C2; 6.
PE 3: Inferred from homology;
KW Calcium {ECO:0000256|ARBA:ARBA00022837};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Cytoplasmic vesicle {ECO:0000256|ARBA:ARBA00023329};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000007303};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal-anchor {ECO:0000256|ARBA:ARBA00022968};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 1965..1987
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 1..101
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT DOMAIN 168..293
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT DOMAIN 332..468
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT DOMAIN 1100..1228
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT DOMAIN 1264..1388
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT DOMAIN 1706..1856
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT REGION 127..180
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1914..1938
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 716..753
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 1914..1929
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2000 AA; 226929 MW; 5D8752BC5BDE1D6B CRC64;
MLRVVVESAS GIPKKKLGNP DPIAAVVFRG LKKKTKAIDN ELNPVWNEVL EFLKCSPLDA
IIVLFDVVVK DFETIGKDKF IGSAKIHLRD LASGQARSLP SKNVPLMNEK QQAVGATINL
LIGYEPPPNA TTTVNDQPDA GGANDGDEGE ILVDRGGQGG GVKSAWGNPS ESQADSPVRR
HRALANKPQD FQIRVRVIEG RQLPGNNIKP VVKVNLCGQT HRTRIRRGNN PFFDETFFYN
VNMLPSELLD ESISLRVYDS FSLRADSLMG EFKLDVGYIY DEPEGQAIMR KWLLLSDADD
STSGARGYLK VSIIVLGIGD EPPMERRDVT EEQDDIESNL LVPAGVTLRW ATLSLKVYRA
EDIPQMDDAF LQTVKQVFGG DVDKKNLVDP YVELNFAGKK SCTKIIEKNA NPEWNQLINL
QVKFPSMCER VKLTMYDWDC LTKDDAVGTA FLNLSTMSSS GGEIEGNNLS SYRLSAAASE
IGFLPAFGCY INLYGSPREF TLPDPYEELN LGKVRGVAYR AGGSFVELST QLDGNSPKKK
KNDLHICCMN KKYQRRRKYS LCAVFHSACM LQEPGEAIQF EVSIGNYGNK LDSTCKPLSS
TTQYSFAVFD GNHYYYLPWA DTKPVVIVNS YWEDISHRLD SVNILLHLAD RLEINLTQLK
TAVLAKVAET RLKEIWLKVV DHMLDDINSF QLPVLEDRPN ITALDLQLKI LRDAALKSLQ
KMAVRMKEEA TDIKATIGDI EDWLDRLKQL AEEPQNSMPD VIIWMLRGEK RVAYARVPAN
EILYSNFSEQ ARGKHCGRTQ TIFMQYPMDK NKGLKVPVQL RVSMWLGLSA LDEKFNSFSE
GSFSVYAEMY ENQACVLGKW GTTGLVGRHK FSDVTGKVKL KKERFLPPRG WEWEGDWFVD
PARCLLTEAD AGHTEFIDEV FQNETRFPGG DWKLAAEPYT DVNGEKAQSP GEFECPPGWK
WEDDWSFNSD GAVDEQGWEY GITIPPDDKP KSWVAAEKMY HIHRRKRLIR QRKKISDQTV
PAEVRRERRE PVEGWEYSSL IGKKFHRKER STDAFRRCRW RRKMVPSDCI GSSAVFKLEG
ALGVDVDEKA DKAVAAKVFG ANTPTVSCHF SRSHIYHLRV YVYQGKNLCA MDKDSFSDPY
VHVSFLHVSK TTKVIRATLN PTWDQTLIFE NIEIYGDPET VVRSPPDVVL ELFDSDQVGK
DEPMGRCTCP PVVKLNPSMG GTPKLLWFPV SKKGRGAGEV LLAAELLLND KANEGDLPLD
PPRREGLYMV PQGIRPVVQQ TAIEVLTWGL RNMKSYQLAT VSSPSLIVEC GGEIVHTAVI
RNFKKNPNFP GSLLLLKVLL PKEEMYTPPI VLKVIDHRPF GRKPVVGQCT IDCLEEFRCD
PYRISNDTCM SARVAMITAA PSDVVIDVEE SPILNTVVQA EKEEEAVDWW SKFFASVGDE
EKCGPYLKKG YDKLQVYNTE LEEVPQFNGL TDFCRTFKLR RGKTDDDDEE DPSVVGEFKV
KIQDFFFFFR LQCSIPELLG YFIFLSLYFT NNFLSLYLFR MFELSCFIPQ DKDLKIAVYD
YDLLSRDEKV GETVIDLENR LLSRYRSSCG LPQTYCTSGI NQWRDQLKPS QILQHLAKLR
GIRPPSFEGD GSSLSFSGKQ YNLQDFETNT EIHPHLGPAN ERLALHVLKN QGLVPEHVET
RTLYSSHQPQ LSQGQIQMWV DIFPKNLGLP GPPCVINPRK AKKYFLRAII WNTTNVILDE
KSITGENMSD IYVKGWMPGM EEQKQKTDVH YRSLDGDGNF NWRFVFEFDY LPAEQLCVVS
RKDHFWNLDK TEFRIPPKMI VQIWDNDKFS LDDYLGSVEL DLLNLIPPAK SPEKCSLKML
PGLPNSNSLK KPVPNSLFSQ KAVRGWWPCV IGQDGEDVLG GKVEMTLEIV EEKEMQERPA
GKGRDEPNMN PKLDQPNNSR PDTSFFWFTN PCKTMKFIIW RRFKWIFLLG IILLLVILFL
GILFYSLPNY ISMKIVKPFS
//
