ID H3CTG6_TETNG Unreviewed; 409 AA.
AC H3CTG6;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 1.
DT 27-MAR-2024, entry version 54.
DE SubName: Full=Neutral cholesterol ester hydrolase 1b, tandem duplicate 1 {ECO:0000313|Ensembl:ENSTNIP00000011550.1};
OS Tetraodon nigroviridis (Spotted green pufferfish) (Chelonodon
OS nigroviridis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Tetraodon.
OX NCBI_TaxID=99883 {ECO:0000313|Ensembl:ENSTNIP00000011550.1, ECO:0000313|Proteomes:UP000007303};
RN [1] {ECO:0000313|Proteomes:UP000007303}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15496914; DOI=10.1038/nature03025;
RA Jaillon O., Aury J.-M., Brunet F., Petit J.-L., Stange-Thomann N.,
RA Mauceli E., Bouneau L., Fischer C., Ozouf-Costaz C., Bernot A., Nicaud S.,
RA Jaffe D., Fisher S., Lutfalla G., Dossat C., Segurens B., Dasilva C.,
RA Salanoubat M., Levy M., Boudet N., Castellano S., Anthouard V., Jubin C.,
RA Castelli V., Katinka M., Vacherie B., Biemont C., Skalli Z., Cattolico L.,
RA Poulain J., De Berardinis V., Cruaud C., Duprat S., Brottier P.,
RA Coutanceau J.-P., Gouzy J., Parra G., Lardier G., Chapple C.,
RA McKernan K.J., McEwan P., Bosak S., Kellis M., Volff J.-N., Guigo R.,
RA Zody M.C., Mesirov J., Lindblad-Toh K., Birren B., Nusbaum C., Kahn D.,
RA Robinson-Rechavi M., Laudet V., Schachter V., Quetier F., Saurin W.,
RA Scarpelli C., Wincker P., Lander E.S., Weissenbach J., Roest Crollius H.;
RT "Genome duplication in the teleost fish Tetraodon nigroviridis reveals the
RT early vertebrate proto-karyotype.";
RL Nature 431:946-957(2004).
RN [2] {ECO:0000313|Ensembl:ENSTNIP00000011550.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the 'GDXG' lipolytic enzyme family.
CC {ECO:0000256|ARBA:ARBA00010515}.
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DR AlphaFoldDB; H3CTG6; -.
DR STRING; 99883.ENSTNIP00000011550; -.
DR ESTHER; tetng-h3ctg6; Arylacetamide_deacetylase.
DR Ensembl; ENSTNIT00000011732.1; ENSTNIP00000011550.1; ENSTNIG00000008700.1.
DR GeneTree; ENSGT00940000156699; -.
DR HOGENOM; CLU_012494_12_0_1; -.
DR InParanoid; H3CTG6; -.
DR OMA; DSWKLML; -.
DR TreeFam; TF314978; -.
DR Proteomes; UP000007303; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:InterPro.
DR GO; GO:0052689; F:carboxylic ester hydrolase activity; IEA:InterPro.
DR Gene3D; 3.40.50.1820; alpha/beta hydrolase; 1.
DR InterPro; IPR029058; AB_hydrolase.
DR InterPro; IPR013094; AB_hydrolase_3.
DR InterPro; IPR017157; Arylacetamide_deacetylase.
DR InterPro; IPR033140; Lipase_GDXG_put_SER_AS.
DR PANTHER; PTHR23024; ARYLACETAMIDE DEACETYLASE; 1.
DR PANTHER; PTHR23024:SF671; ZGC:153038-RELATED; 1.
DR Pfam; PF07859; Abhydrolase_3; 2.
DR PIRSF; PIRSF037251; Arylacetamide_deacetylase; 1.
DR SUPFAM; SSF53474; alpha/beta-Hydrolases; 1.
DR PROSITE; PS01174; LIPASE_GDXG_SER; 1.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Reference proteome {ECO:0000313|Proteomes:UP000007303}.
FT DOMAIN 109..276
FT /note="Alpha/beta hydrolase fold-3"
FT /evidence="ECO:0000259|Pfam:PF07859"
FT DOMAIN 319..382
FT /note="Alpha/beta hydrolase fold-3"
FT /evidence="ECO:0000259|Pfam:PF07859"
FT ACT_SITE 191
FT /evidence="ECO:0000256|PIRSR:PIRSR037251-1,
FT ECO:0000256|PROSITE-ProRule:PRU10038"
FT ACT_SITE 349
FT /evidence="ECO:0000256|PIRSR:PIRSR037251-1"
FT ACT_SITE 379
FT /evidence="ECO:0000256|PIRSR:PIRSR037251-1"
SQ SEQUENCE 409 AA; 45078 MW; D1040194F74DDCAA CRC64;
SVRMRLLLAG AVLLSAAAYY VYLPLPSGVS EPWKLMLLDA LFRSVMQASD AAHALGVCHR
LHLLNRLVSW VEETEARSCD AVHVTDSTLG GVPTRVFHPV GGGQLKRGIV YFHGGGWALG
SARMRSYDLL CRKMAKDLDS VVVSVDYRLA PEAVFPDQYH DALAASRAFL SPEVLERYGI
DPNRVCVSGD SSGGNLAAAV AQELGSDDRQ SIRFKVQALI YPVLQALDFH TASYQQNQAV
PILHRPLMAR FWLQYLGADP SLEPLLLTNN HSSLDQLLIG ADARSKVDWT TLLPAERRKH
FRPVIRPRGS PRAMGAVPQL MDARAAPLLA DRAVLGRTPT AYVLTCEFDV LRDDGLMYVR
RLQEAGVTAT SDHYEDGFHG CMAFSFLPVA SSVGRRSLDN YISWLDHNL
//
