ID H3CU89_TETNG Unreviewed; 1044 AA.
AC H3CU89;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 1.
DT 27-MAR-2024, entry version 62.
DE RecName: Full=UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit {ECO:0000256|ARBA:ARBA00015782};
DE EC=2.4.1.255 {ECO:0000256|ARBA:ARBA00011970};
DE AltName: Full=O-GlcNAc transferase subunit p110 {ECO:0000256|ARBA:ARBA00029769};
DE AltName: Full=O-linked N-acetylglucosamine transferase 110 kDa subunit {ECO:0000256|ARBA:ARBA00031470};
OS Tetraodon nigroviridis (Spotted green pufferfish) (Chelonodon
OS nigroviridis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Tetraodon.
OX NCBI_TaxID=99883 {ECO:0000313|Ensembl:ENSTNIP00000011823.1, ECO:0000313|Proteomes:UP000007303};
RN [1] {ECO:0000313|Proteomes:UP000007303}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15496914; DOI=10.1038/nature03025;
RA Jaillon O., Aury J.-M., Brunet F., Petit J.-L., Stange-Thomann N.,
RA Mauceli E., Bouneau L., Fischer C., Ozouf-Costaz C., Bernot A., Nicaud S.,
RA Jaffe D., Fisher S., Lutfalla G., Dossat C., Segurens B., Dasilva C.,
RA Salanoubat M., Levy M., Boudet N., Castellano S., Anthouard V., Jubin C.,
RA Castelli V., Katinka M., Vacherie B., Biemont C., Skalli Z., Cattolico L.,
RA Poulain J., De Berardinis V., Cruaud C., Duprat S., Brottier P.,
RA Coutanceau J.-P., Gouzy J., Parra G., Lardier G., Chapple C.,
RA McKernan K.J., McEwan P., Bosak S., Kellis M., Volff J.-N., Guigo R.,
RA Zody M.C., Mesirov J., Lindblad-Toh K., Birren B., Nusbaum C., Kahn D.,
RA Robinson-Rechavi M., Laudet V., Schachter V., Quetier F., Saurin W.,
RA Scarpelli C., Wincker P., Lander E.S., Weissenbach J., Roest Crollius H.;
RT "Genome duplication in the teleost fish Tetraodon nigroviridis reveals the
RT early vertebrate proto-karyotype.";
RL Nature 431:946-957(2004).
RN [2] {ECO:0000313|Ensembl:ENSTNIP00000011823.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- PATHWAY: Protein modification; protein glycosylation.
CC {ECO:0000256|ARBA:ARBA00004922}.
CC -!- SIMILARITY: Belongs to the glycosyltransferase 41 family. O-GlcNAc
CC transferase subfamily. {ECO:0000256|ARBA:ARBA00005386}.
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DR AlphaFoldDB; H3CU89; -.
DR STRING; 99883.ENSTNIP00000011823; -.
DR Ensembl; ENSTNIT00000012013.1; ENSTNIP00000011823.1; ENSTNIG00000008969.1.
DR GeneTree; ENSGT00940000155085; -.
DR HOGENOM; CLU_001721_1_1_1; -.
DR InParanoid; H3CU89; -.
DR OMA; HAYSEKL; -.
DR TreeFam; TF105785; -.
DR UniPathway; UPA00378; -.
DR Proteomes; UP000007303; Unassembled WGS sequence.
DR GO; GO:0097363; F:protein O-acetylglucosaminyltransferase activity; IEA:UniProtKB-EC.
DR GO; GO:0006486; P:protein glycosylation; IEA:UniProtKB-UniPathway.
DR Gene3D; 3.30.720.150; -; 1.
DR Gene3D; 3.40.50.11380; -; 1.
DR Gene3D; 3.40.50.2000; Glycogen Phosphorylase B; 1.
DR Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 2.
DR InterPro; IPR029489; OGT/SEC/SPY_C.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR InterPro; IPR001440; TPR_1.
DR InterPro; IPR019734; TPR_repeat.
DR PANTHER; PTHR44366; UDP-N-ACETYLGLUCOSAMINE--PEPTIDE N-ACETYLGLUCOSAMINYLTRANSFERASE 110 KDA SUBUNIT; 1.
DR PANTHER; PTHR44366:SF1; UDP-N-ACETYLGLUCOSAMINE--PEPTIDE N-ACETYLGLUCOSAMINYLTRANSFERASE 110 KDA SUBUNIT; 1.
DR Pfam; PF13844; Glyco_transf_41; 1.
DR Pfam; PF00515; TPR_1; 2.
DR Pfam; PF13414; TPR_11; 3.
DR Pfam; PF13424; TPR_12; 1.
DR Pfam; PF13181; TPR_8; 1.
DR SMART; SM00028; TPR; 12.
DR SUPFAM; SSF48452; TPR-like; 2.
DR PROSITE; PS50005; TPR; 11.
DR PROSITE; PS50293; TPR_REGION; 5.
PE 3: Inferred from homology;
KW Glycosyltransferase {ECO:0000256|ARBA:ARBA00022676};
KW Reference proteome {ECO:0000313|Proteomes:UP000007303};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW TPR repeat {ECO:0000256|ARBA:ARBA00022803, ECO:0000256|PROSITE-
KW ProRule:PRU00339}; Transferase {ECO:0000256|ARBA:ARBA00022676}.
FT REPEAT 87..120
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT REPEAT 121..154
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT REPEAT 155..188
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT REPEAT 189..222
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT REPEAT 223..256
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT REPEAT 257..290
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT REPEAT 291..324
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT REPEAT 325..358
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT REPEAT 359..392
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT REPEAT 393..426
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT REPEAT 427..460
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT DOMAIN 474..1014
FT /note="O-GlcNAc transferase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF13844"
SQ SEQUENCE 1044 AA; 116368 MW; 5FBB204C49D38BE5 CRC64;
MATSVGNVAD STEPTKRMLS FQGLAELAHR EYQSGDFEAA ERHCMQLWRQ EPDNTVGLLS
VLSAICRRPN RSAHFSTLAI KQNPLLAEAY SNLGNVYKER GQLQEAIEHY RHALRLKPDF
IDGYINLAAA LVAAGDMEGA VQAYVSALQY NPDLYCVRSD LGNLLKALGR LEEAKACYLK
AIETQPNFAV AWSNLGCVFN AQGEIWLAIH HFEKAVTLDP NFLDAYINLG NVLKEARIFD
RAVAGYLRAL SLSPNHAVVH GNLACVYYEQ GLIDLAIDTY RRAIELQPHF PDAYCNLANA
LKEKGNVSEA EECYNTALRL CPTHADSLNN LANIKREQGN IEEAIQLYRK ALEVFPEFAA
AHSNLASVLQ QQGKLQEALM HYKEAIRISP TFADAYSNMG NTLKEMQDVQ GALQCYTRAI
QINPAFADAH SNLASIHKDS GNIPEAIASY RTALKLKPDF PDAYCNLAHC LQIVCDWTDY
DERMKKLVTI VADQLDKNRL PSVHPHHSML YPLSHGFRKA IAERHGNLCL DKINALHKPP
YEHPKDLKAS GGRLRVGYVS SDFGNHPTSH LMQSIPGMHN PEKFEVFCYA LSPDDSTNFR
VKVVAEAHHF VDLSQISCNG KAADRIHQDG VHILVNMNGY TKGARNELFA LRPAPVQAMW
LGYPGTSGAP FMDYIISDKE TSPIEVAEQY SEKLAYMPHT FFIGDHANMF PHLKKKAVID
FKSNGHIFDN RIVLNGIDLK AFLDSLPDVK VIKMKCDNNQ EPSADTNGAL SMPVIPMNTA
AEAIINMINQ GQIQVTINGF TVSNGLATTQ ITNKAATGEE VLRTVVVTTR SQYGLPEDAI
VYCNFNQLYK IDPPTLQMWA NILTRVPNSV LWLLRFPAVG EPNIQQYAQK VGLPASRIIF
SPVAPKEEHV RRGQLADVCL DTPLCNGHTT GMDVLWAGTP MVTMPGETLA SRVATSQLSC
LGCPELIAQS HEEYEDIAVK LGSDMEYLKM VRARVWKQRI CSPLFNTKQY TMDLEKLYLR
MWEHYSKGNK PEHLVQTVEA SENA
//
