ID H3CV10_TETNG Unreviewed; 372 AA.
AC H3CV10;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 1.
DT 27-MAR-2024, entry version 51.
DE RecName: Full=Apple domain-containing protein {ECO:0000259|PROSITE:PS50948};
OS Tetraodon nigroviridis (Spotted green pufferfish) (Chelonodon
OS nigroviridis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Tetraodon.
OX NCBI_TaxID=99883 {ECO:0000313|Ensembl:ENSTNIP00000012094.1, ECO:0000313|Proteomes:UP000007303};
RN [1] {ECO:0000313|Proteomes:UP000007303}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15496914; DOI=10.1038/nature03025;
RA Jaillon O., Aury J.-M., Brunet F., Petit J.-L., Stange-Thomann N.,
RA Mauceli E., Bouneau L., Fischer C., Ozouf-Costaz C., Bernot A., Nicaud S.,
RA Jaffe D., Fisher S., Lutfalla G., Dossat C., Segurens B., Dasilva C.,
RA Salanoubat M., Levy M., Boudet N., Castellano S., Anthouard V., Jubin C.,
RA Castelli V., Katinka M., Vacherie B., Biemont C., Skalli Z., Cattolico L.,
RA Poulain J., De Berardinis V., Cruaud C., Duprat S., Brottier P.,
RA Coutanceau J.-P., Gouzy J., Parra G., Lardier G., Chapple C.,
RA McKernan K.J., McEwan P., Bosak S., Kellis M., Volff J.-N., Guigo R.,
RA Zody M.C., Mesirov J., Lindblad-Toh K., Birren B., Nusbaum C., Kahn D.,
RA Robinson-Rechavi M., Laudet V., Schachter V., Quetier F., Saurin W.,
RA Scarpelli C., Wincker P., Lander E.S., Weissenbach J., Roest Crollius H.;
RT "Genome duplication in the teleost fish Tetraodon nigroviridis reveals the
RT early vertebrate proto-karyotype.";
RL Nature 431:946-957(2004).
RN [2] {ECO:0000313|Ensembl:ENSTNIP00000012094.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR AlphaFoldDB; H3CV10; -.
DR STRING; 99883.ENSTNIP00000012094; -.
DR Ensembl; ENSTNIT00000012285.1; ENSTNIP00000012094.1; ENSTNIG00000009229.1.
DR GeneTree; ENSGT00940000158569; -.
DR HOGENOM; CLU_063476_0_0_1; -.
DR InParanoid; H3CV10; -.
DR OMA; ADAYGCC; -.
DR TreeFam; TF343687; -.
DR Proteomes; UP000007303; Unassembled WGS sequence.
DR GO; GO:0005576; C:extracellular region; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:InterPro.
DR CDD; cd01100; APPLE_Factor_XI_like; 4.
DR Gene3D; 3.50.4.10; Hepatocyte Growth Factor; 4.
DR InterPro; IPR000177; Apple.
DR InterPro; IPR003609; Pan_app.
DR PANTHER; PTHR33946; -; 1.
DR PANTHER; PTHR33946:SF4; COAGULATION FACTOR XI; 1.
DR Pfam; PF00024; PAN_1; 4.
DR PRINTS; PR00005; APPLEDOMAIN.
DR SMART; SM00223; APPLE; 4.
DR SUPFAM; SSF57414; Hairpin loop containing domain-like; 3.
DR PROSITE; PS00495; APPLE; 1.
DR PROSITE; PS50948; PAN; 2.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000007303};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..19
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 20..372
FT /note="Apple domain-containing protein"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5003581262"
FT DOMAIN 105..196
FT /note="Apple"
FT /evidence="ECO:0000259|PROSITE:PS50948"
FT DOMAIN 207..281
FT /note="Apple"
FT /evidence="ECO:0000259|PROSITE:PS50948"
SQ SEQUENCE 372 AA; 42302 MW; B71F44D3BA6E658E CRC64;
MDKYLMSAVL LSVCGLGFSQ ECRKDFQNNI DFPGTDVSQI YASDAERCQE LCTDHHSCLF
FTFIRPDWTR DTRHFYCYLK FTASGEPKTK TPLLGVTSGY SLKPCTSELT GPYLPLVYQN
IDFLGADYRF LFTANYEDCQ RVCTEDPSCR FFTFTNGDFS PEAYRYKCHL KYSWTVPRPP
VIVALANVVS GFSNNLQMPF PRFDTACEGK LFPNIDIEGN HFEEVAAVSD EHCQMLCTAH
PRCTLFSFAS QGFSCRLRDN LNAMEIKAKL GVTSGIPGRG CHLSDSWARA PYPGVDFRGV
DIRYTLVDNA EACQQACNDE DKCQFYTYVK ENFRDPAYRR RCYLKRSITI PSPPKIRKLQ
NVVSGFSLSL SP
//
