ID H3CWI6_TETNG Unreviewed; 2473 AA.
AC H3CWI6;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 1.
DT 27-MAR-2024, entry version 60.
DE SubName: Full=Insulin-like growth factor 2 receptor {ECO:0000313|Ensembl:ENSTNIP00000012620.1};
OS Tetraodon nigroviridis (Spotted green pufferfish) (Chelonodon
OS nigroviridis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Tetraodon.
OX NCBI_TaxID=99883 {ECO:0000313|Ensembl:ENSTNIP00000012620.1, ECO:0000313|Proteomes:UP000007303};
RN [1] {ECO:0000313|Proteomes:UP000007303}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15496914; DOI=10.1038/nature03025;
RA Jaillon O., Aury J.-M., Brunet F., Petit J.-L., Stange-Thomann N.,
RA Mauceli E., Bouneau L., Fischer C., Ozouf-Costaz C., Bernot A., Nicaud S.,
RA Jaffe D., Fisher S., Lutfalla G., Dossat C., Segurens B., Dasilva C.,
RA Salanoubat M., Levy M., Boudet N., Castellano S., Anthouard V., Jubin C.,
RA Castelli V., Katinka M., Vacherie B., Biemont C., Skalli Z., Cattolico L.,
RA Poulain J., De Berardinis V., Cruaud C., Duprat S., Brottier P.,
RA Coutanceau J.-P., Gouzy J., Parra G., Lardier G., Chapple C.,
RA McKernan K.J., McEwan P., Bosak S., Kellis M., Volff J.-N., Guigo R.,
RA Zody M.C., Mesirov J., Lindblad-Toh K., Birren B., Nusbaum C., Kahn D.,
RA Robinson-Rechavi M., Laudet V., Schachter V., Quetier F., Saurin W.,
RA Scarpelli C., Wincker P., Lander E.S., Weissenbach J., Roest Crollius H.;
RT "Genome duplication in the teleost fish Tetraodon nigroviridis reveals the
RT early vertebrate proto-karyotype.";
RL Nature 431:946-957(2004).
RN [2] {ECO:0000313|Ensembl:ENSTNIP00000012620.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR STRING; 99883.ENSTNIP00000012620; -.
DR Ensembl; ENSTNIT00000012811.1; ENSTNIP00000012620.1; ENSTNIG00000009734.1.
DR GeneTree; ENSGT00390000013943; -.
DR HOGENOM; CLU_001182_0_0_1; -.
DR InParanoid; H3CWI6; -.
DR OMA; DNCEVRD; -.
DR TreeFam; TF328963; -.
DR Proteomes; UP000007303; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005537; F:mannose binding; IEA:InterPro.
DR GO; GO:0038023; F:signaling receptor activity; IEA:InterPro.
DR GO; GO:0007041; P:lysosomal transport; IEA:InterPro.
DR CDD; cd00062; FN2; 1.
DR Gene3D; 2.10.10.10; Fibronectin, type II, collagen-binding; 1.
DR Gene3D; 2.70.130.10; Mannose-6-phosphate receptor binding domain; 15.
DR InterPro; IPR000479; CIMR_rpt.
DR InterPro; IPR000562; FN_type2_dom.
DR InterPro; IPR036943; FN_type2_sf.
DR InterPro; IPR013806; Kringle-like.
DR InterPro; IPR009011; Man6P_isomerase_rcpt-bd_dom_sf.
DR InterPro; IPR044865; MRH_dom.
DR PANTHER; PTHR15071:SF0; CATION-INDEPENDENT MANNOSE-6-PHOSPHATE RECEPTOR; 1.
DR PANTHER; PTHR15071; MANNOSE-6-PHOSPHATE RECEPTOR FAMILY MEMBER; 1.
DR Pfam; PF00878; CIMR; 14.
DR Pfam; PF00040; fn2; 1.
DR SMART; SM01404; CIMR; 14.
DR SMART; SM00059; FN2; 1.
DR SUPFAM; SSF57440; Kringle-like; 1.
DR SUPFAM; SSF50911; Mannose 6-phosphate receptor domain; 15.
DR PROSITE; PS51092; FN2_2; 1.
DR PROSITE; PS51914; MRH; 15.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00479};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000007303};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 2275..2296
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 3..117
FT /note="MRH"
FT /evidence="ECO:0000259|PROSITE:PS51914"
FT DOMAIN 126..273
FT /note="MRH"
FT /evidence="ECO:0000259|PROSITE:PS51914"
FT DOMAIN 279..428
FT /note="MRH"
FT /evidence="ECO:0000259|PROSITE:PS51914"
FT DOMAIN 433..584
FT /note="MRH"
FT /evidence="ECO:0000259|PROSITE:PS51914"
FT DOMAIN 590..731
FT /note="MRH"
FT /evidence="ECO:0000259|PROSITE:PS51914"
FT DOMAIN 734..887
FT /note="MRH"
FT /evidence="ECO:0000259|PROSITE:PS51914"
FT DOMAIN 893..1032
FT /note="MRH"
FT /evidence="ECO:0000259|PROSITE:PS51914"
FT DOMAIN 1035..1174
FT /note="MRH"
FT /evidence="ECO:0000259|PROSITE:PS51914"
FT DOMAIN 1180..1326
FT /note="MRH"
FT /evidence="ECO:0000259|PROSITE:PS51914"
FT DOMAIN 1330..1470
FT /note="MRH"
FT /evidence="ECO:0000259|PROSITE:PS51914"
FT DOMAIN 1476..1618
FT /note="MRH"
FT /evidence="ECO:0000259|PROSITE:PS51914"
FT DOMAIN 1620..1766
FT /note="MRH"
FT /evidence="ECO:0000259|PROSITE:PS51914"
FT DOMAIN 1771..1960
FT /note="MRH"
FT /evidence="ECO:0000259|PROSITE:PS51914"
FT DOMAIN 1867..1915
FT /note="Fibronectin type-II"
FT /evidence="ECO:0000259|PROSITE:PS51092"
FT DOMAIN 1963..2099
FT /note="MRH"
FT /evidence="ECO:0000259|PROSITE:PS51914"
FT DOMAIN 2125..2251
FT /note="MRH"
FT /evidence="ECO:0000259|PROSITE:PS51914"
FT REGION 2347..2376
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2442..2473
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2348..2362
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2455..2473
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 1872..1898
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00479"
FT DISULFID 1886..1913
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00479"
SQ SEQUENCE 2473 AA; 271173 MW; 1F5C4A07132227E0 CRC64;
FALCCSYKWE AIDKDKNVSY TLRLCSSSTP TSCGSDAAVC ARNLSTNSSQ SVGNLSLQRI
SGRVLDYNTS TKCQDGSNNV QTSFSFLCGK TMGTPEFVAV SQCVHYFEWR TYAACKNNKF
KPQKEVPCSV FDADGKKHDL SPLIRASDGV LVDDGDDSID FYINICRSLN LPEKSCPEGS
AACLVTSQGS FNMGSPTKPL ELLSNDRYLL RLKLQYEAGS DSTPPEFCKD HVPAVSITFI
CPSRRHQGSS PKMIAESNCR YEVEWVTEYA CHRDYLESHT CKLNSEQHDL SIDLTPLTRT
TTDLPYSAPS GPSSGSDSYV YYLNVCGEVF TEECGSDKFV SSCQVKTSGN VNKVAGKYQN
QTLRYSDGDL ILIYPGGSTC SSGFERMTII TFECNKTASN SGQGTPVFAG ETDCTYYFNW
ETAFACVKEK EDLLCQVQDG KKHYDLSPLT RFPGTDVNGN WEVVDAHSPK SDSHFYLNVC
HKVVQSGGAV GCPAKASVCA VGKDRQYLSL GSFLSSPQKT EIGNDIRLVY SDGSFCNNNR
KRIRTILTLK CKPGDLESAP ILRSIAADEC VYELEWYTAA ACVLSKTQGD DCRVEDPRAD
LSFDLSPLTK TEGKFYNVKG DNYDYYINVC AGVKADGCPE KSGACQVERR QGVSQRSWSL
GEANSRLSYY DGLIQLVYSN GSQYNDDKHT ARSTLISFMC DPDAGAGHPE FQVEDTYTYN
FHWYTSYACP ERPHECLVTD PVTLDQYDLS SLSHSTSANN WHVMDFSDPL NPKKYYFNIC
RPITPVLGCD RHASVCQMRY EQGSMKEVVS VSNMGMAKGG PIIEDRDRLL LKFTDGSNCT
SDGQKLSYST LIYLACSRGA QSRKPRFLMY QNCTASFMWE TRAACAVATT KSENCSVVDP
NTGFEFNLQL LASEKGYSDT KNGKEFLVNI CSNMSKCGAG NAGCVLEDGV PFSQVGAERS
LQYSSNGLLT LTYKGQLDKP TGKRDTFTIN FVCDPNSHPG SLKLVREEMN TLLNRTVHDV
LFQFFTALAC IPSPVDCQIT DSHGNEYDLS RLIRNGDDAP WVAIDTDAVK SRTFYINVCK
PLPSLKHCPV GPLGACGIIN GRGYNLGYVQ SSPQMVEDGS ISIIYQNGDR CGSTSFYSTR
IILQCDDHPG SPMFDRRDGC EYVFIWRTSE ACPVRKSQGD ECQVRDSRSG YLFNLNSLKG
KDYRLQNGKY TYHLSVCGGL QTGVCAHKDP SSGEVASCQV EGSRHKIGGT ETSKIAGIAN
QVLSYVEDQL ILNYTGGETC HKIYQRSTEI YFSCHPDQNP GAPEFIKETP DCTYMFSWPT
ALACVPIKTT SCSYNDGQGR SYDLSPLALD TGNWEVQHSF GDTSKKIYIN VCRSLVQMGG
SWACPSSAAA CMKVGNEYVS LGHVESGPTL DTNVLSLKYT SGQACPHTKG NRTSIIRFKC
EKVESRPMLI SAIEDCVYTF LWLTPVACPL NSTQQDECRV TNPATGYSFD LSALTKVGGY
TVYDPKDNRK SVGINICGNL PDSGCDPNAA VCIRDASTAV SGGQVSKKLS YKDQVLELIY
EEGSPCAANP KLKHKTVIHF ICRPPKMASA NPEPVLIYSD ADTCMHFFSF HTPQVCETTV
KCSVQNGSEL IELSPLIHAT GYYTATDEAV DQSDKTPDFY INICQPLNPI PDVTCPPGAA
VCMNPENGPP VDIGRTTSGP EINKATGKVF ISYSSSTQCA ADPSQNYTST IIFTCQRGLE
LGSPQMLRLQ GCVYLFEWAT PIVCSDAEHT SGCQLTDAQL EFTFDLSVLK GEVQVPANGS
TYHINVCGSV TEPACENSAV CRVSGSGPEK LVSSFGLTKV MNMEFKHKER GVLMEYGGGD
PCPPLTTDGE LCVFPFTFMK KTYKECTKVE RMGSKPFCST TASYDTDGKW GVCEEASSKR
RSSILFLCDY SAGRGTPELL FETADCLASF KWMTSAVCPP PKMDCKLVSQ HLTFNLRTLS
SLSEPWKFSH HGDSYFMNLC QGVHGILTGC PEDAAVCRRT AAGKIQVLGR VFTQRMSYND
GNISVTYAAG DDACGRGVEA KTEIRLGCGP TLGHPVLISA DEASCEFLIG WETRLACAVK
QQEVEMVNGT IAIPDLGRNL SLGALYFSHH QASGDIRSNG DRYIYHIQLS GITNNSLPSC
VGANICQVKL NGAYNRQIGF SSKAKYYIKG ATLDVIVPSN SSCGRGESQT VSSTITFQCS
PSAGVGIPEF MLETDECQYL FVWHTDAVCV LTTVEQKLHE DDDSGTLPLL RRSQALGVVL
SVLLLGLAVC LLGLLLHKRE RRELVMQKVA SCCRRTTQVS YKYSKVNMDE DAGEEEMEWL
MEEMEAPPIS SSLSSQRGRS HHGNGHITTK PVNADGLRSF TLDDQEDDSE DEVLSVPGVR
VLRPPGGSRN AAAHGSVFLQ EESDEDLVGL LDESDRKTKG GKLRLSAVTR GNSTAAIRKR
EEEEDSDEDL LRV
//
