ID H3CWN5_TETNG Unreviewed; 429 AA.
AC H3CWN5;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 1.
DT 27-MAR-2024, entry version 63.
DE SubName: Full=Usher syndrome 1Ga (autosomal recessive) {ECO:0000313|Ensembl:ENSTNIP00000012669.1};
GN Name=USH1G {ECO:0000313|Ensembl:ENSTNIP00000012669.1};
OS Tetraodon nigroviridis (Spotted green pufferfish) (Chelonodon
OS nigroviridis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Tetraodon.
OX NCBI_TaxID=99883 {ECO:0000313|Ensembl:ENSTNIP00000012669.1, ECO:0000313|Proteomes:UP000007303};
RN [1] {ECO:0000313|Proteomes:UP000007303}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15496914; DOI=10.1038/nature03025;
RA Jaillon O., Aury J.-M., Brunet F., Petit J.-L., Stange-Thomann N.,
RA Mauceli E., Bouneau L., Fischer C., Ozouf-Costaz C., Bernot A., Nicaud S.,
RA Jaffe D., Fisher S., Lutfalla G., Dossat C., Segurens B., Dasilva C.,
RA Salanoubat M., Levy M., Boudet N., Castellano S., Anthouard V., Jubin C.,
RA Castelli V., Katinka M., Vacherie B., Biemont C., Skalli Z., Cattolico L.,
RA Poulain J., De Berardinis V., Cruaud C., Duprat S., Brottier P.,
RA Coutanceau J.-P., Gouzy J., Parra G., Lardier G., Chapple C.,
RA McKernan K.J., McEwan P., Bosak S., Kellis M., Volff J.-N., Guigo R.,
RA Zody M.C., Mesirov J., Lindblad-Toh K., Birren B., Nusbaum C., Kahn D.,
RA Robinson-Rechavi M., Laudet V., Schachter V., Quetier F., Saurin W.,
RA Scarpelli C., Wincker P., Lander E.S., Weissenbach J., Roest Crollius H.;
RT "Genome duplication in the teleost fish Tetraodon nigroviridis reveals the
RT early vertebrate proto-karyotype.";
RL Nature 431:946-957(2004).
RN [2] {ECO:0000313|Ensembl:ENSTNIP00000012669.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR AlphaFoldDB; H3CWN5; -.
DR STRING; 99883.ENSTNIP00000012669; -.
DR Ensembl; ENSTNIT00000012861.1; ENSTNIP00000012669.1; ENSTNIG00000009782.1.
DR GeneTree; ENSGT00390000017548; -.
DR HOGENOM; CLU_028071_0_0_1; -.
DR InParanoid; H3CWN5; -.
DR OMA; VMYVGTF; -.
DR TreeFam; TF324946; -.
DR Proteomes; UP000007303; Unassembled WGS sequence.
DR GO; GO:0050957; P:equilibrioception; IEA:InterPro.
DR GO; GO:0050953; P:sensory perception of light stimulus; IEA:InterPro.
DR GO; GO:0007605; P:sensory perception of sound; IEA:InterPro.
DR CDD; cd09586; SAM_USH1G; 1.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 1.
DR Gene3D; 1.10.150.50; Transcription Factor, Ets-1; 1.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR001660; SAM.
DR InterPro; IPR013761; SAM/pointed_sf.
DR InterPro; IPR037602; USH1G_SAM.
DR PANTHER; PTHR24161; ANK_REP_REGION DOMAIN-CONTAINING PROTEIN-RELATED; 1.
DR PANTHER; PTHR24161:SF24; USHER SYNDROME TYPE-1G PROTEIN; 1.
DR Pfam; PF00023; Ank; 1.
DR Pfam; PF12796; Ank_2; 1.
DR Pfam; PF00536; SAM_1; 1.
DR SMART; SM00248; ANK; 3.
DR SMART; SM00454; SAM; 1.
DR SUPFAM; SSF48403; Ankyrin repeat; 1.
DR SUPFAM; SSF47769; SAM/Pointed domain; 1.
DR PROSITE; PS50297; ANK_REP_REGION; 1.
DR PROSITE; PS50088; ANK_REPEAT; 2.
PE 4: Predicted;
KW ANK repeat {ECO:0000256|ARBA:ARBA00023043, ECO:0000256|PROSITE-
KW ProRule:PRU00023}; Reference proteome {ECO:0000313|Proteomes:UP000007303};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT REPEAT 31..63
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 64..96
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT DOMAIN 354..417
FT /note="SAM"
FT /evidence="ECO:0000259|SMART:SM00454"
SQ SEQUENCE 429 AA; 48134 MW; DE6026D4140B3F56 CRC64;
MNDRYHRAAR DGRLDLLKEA TRKELNAPDE DGMTATLWAA YQGNVEALRL IVSRGGNPDK
CDVWGNAPLH LAAANGHHGC LCFLVSVGAN IWCQDNDYHT PLDMAATKGH MDCVRYLDNV
GAKQVELNAK LVRKLKEKAF CDAERRIEAC MRIQEKHRKH MERRFRRETG KASACDATSF
SSYTSSSGSR RATLHATNKG KTKIQRKLEK KKQGDGTFKI YEDGNRGRRN VRDMFPRDNS
DAISRAISEP DLHGPDGDYS EISTDSGHDS LFNRPGLGAM VFRRNYMSGG MFELGGRGGE
VEGRSGDTVR LRSRLQPCSS LDEDSIGSAR SLQERNVEEV PWEEVELGLD DDDEPETSPL
EVFLAALSMS ELFFIFKREK IDLDALLLCS DQDLKSIHIP LGPRKKLLDA CQKHLETIED
PECIEDTDL
//
