ID H3CXW9_TETNG Unreviewed; 500 AA.
AC H3CXW9;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 1.
DT 27-MAR-2024, entry version 67.
DE RecName: Full=Netrin-1 {ECO:0000256|ARBA:ARBA00015919};
OS Tetraodon nigroviridis (Spotted green pufferfish) (Chelonodon
OS nigroviridis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Tetraodon.
OX NCBI_TaxID=99883 {ECO:0000313|Ensembl:ENSTNIP00000013104.1, ECO:0000313|Proteomes:UP000007303};
RN [1] {ECO:0000313|Proteomes:UP000007303}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15496914; DOI=10.1038/nature03025;
RA Jaillon O., Aury J.-M., Brunet F., Petit J.-L., Stange-Thomann N.,
RA Mauceli E., Bouneau L., Fischer C., Ozouf-Costaz C., Bernot A., Nicaud S.,
RA Jaffe D., Fisher S., Lutfalla G., Dossat C., Segurens B., Dasilva C.,
RA Salanoubat M., Levy M., Boudet N., Castellano S., Anthouard V., Jubin C.,
RA Castelli V., Katinka M., Vacherie B., Biemont C., Skalli Z., Cattolico L.,
RA Poulain J., De Berardinis V., Cruaud C., Duprat S., Brottier P.,
RA Coutanceau J.-P., Gouzy J., Parra G., Lardier G., Chapple C.,
RA McKernan K.J., McEwan P., Bosak S., Kellis M., Volff J.-N., Guigo R.,
RA Zody M.C., Mesirov J., Lindblad-Toh K., Birren B., Nusbaum C., Kahn D.,
RA Robinson-Rechavi M., Laudet V., Schachter V., Quetier F., Saurin W.,
RA Scarpelli C., Wincker P., Lander E.S., Weissenbach J., Roest Crollius H.;
RT "Genome duplication in the teleost fish Tetraodon nigroviridis reveals the
RT early vertebrate proto-karyotype.";
RL Nature 431:946-957(2004).
RN [2] {ECO:0000313|Ensembl:ENSTNIP00000013104.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR AlphaFoldDB; H3CXW9; -.
DR STRING; 99883.ENSTNIP00000013104; -.
DR Ensembl; ENSTNIT00000013296.1; ENSTNIP00000013104.1; ENSTNIG00000010205.1.
DR GeneTree; ENSGT00940000153882; -.
DR HOGENOM; CLU_018213_2_0_1; -.
DR InParanoid; H3CXW9; -.
DR TreeFam; TF352481; -.
DR Proteomes; UP000007303; Unassembled WGS sequence.
DR GO; GO:0021960; P:anterior commissure morphogenesis; IEA:Ensembl.
DR GO; GO:0016358; P:dendrite development; IEA:Ensembl.
DR GO; GO:0071678; P:olfactory bulb axon guidance; IEA:Ensembl.
DR GO; GO:0030516; P:regulation of axon extension; IEA:Ensembl.
DR CDD; cd00055; EGF_Lam; 1.
DR Gene3D; 2.60.120.260; Galactose-binding domain-like; 1.
DR Gene3D; 2.10.25.10; Laminin; 1.
DR InterPro; IPR008979; Galactose-bd-like_sf.
DR InterPro; IPR008211; Laminin_N.
DR InterPro; IPR002049; LE_dom.
DR InterPro; IPR001134; Netrin_domain.
DR PANTHER; PTHR10574:SF437; NETRIN-1; 1.
DR PANTHER; PTHR10574; NETRIN/LAMININ-RELATED; 1.
DR Pfam; PF00053; Laminin_EGF; 1.
DR Pfam; PF00055; Laminin_N; 1.
DR SMART; SM00180; EGF_Lam; 1.
DR SMART; SM00136; LamNT; 1.
DR SUPFAM; SSF57196; EGF/Laminin; 1.
DR SUPFAM; SSF49785; Galactose-binding domain-like; 1.
DR PROSITE; PS51117; LAMININ_NTER; 1.
DR PROSITE; PS50189; NTR; 1.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Laminin EGF-like domain {ECO:0000256|ARBA:ARBA00023292};
KW Reference proteome {ECO:0000313|Proteomes:UP000007303};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..24
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 25..500
FT /note="Netrin-1"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5003582794"
FT DOMAIN 47..284
FT /note="Laminin N-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51117"
FT DOMAIN 467..500
FT /note="NTR"
FT /evidence="ECO:0000259|PROSITE:PS50189"
SQ SEQUENCE 500 AA; 55537 MW; 5048E56D0B161C30 CRC64;
KMPRILALFV TTVTLSALTT GVLGGYGLSM FAAQASPPDP CYDENGNPRR CIPDFVNSAF
GKDVRVSSTC GSPAARYCVV AEKGDDRTRD CHTCDASDPK KSRPPAYLTD LNNPHNLTCW
QSENYAQTPQ NVTLTLSLEK KFEVTYVSLQ FCSPRPESMA IYKSMDYGKT WVPFQFYSTQ
SKKMYNRQNK AAITKQNEQE AICTDSHTDM NPLSGGLIAF STLDGRPSAH DFDNSPVLQD
WVTATDIKII FSRLHTFGDE NEDDSELARD SYFYAVSDLQ VGGRCKCNGH ASKCVKDREG
NLVCECKHHT AGPCDRCKPF HYDRPWQRAT AREANECVAA TNCKDNSNLC LLDLHFKALV
EKNLSVLLKC RSHTQNQYVK CHYGLFVTMT EEEDKTDSCK ICVCVCVGGV QGRCRGATGA
VEVKEIKGKT GLRAGRNNSG TDQFPSPVCP LVHDQPPPPQ LTRAIDCDSH CKASKGKMKI
TMKKYCKKDY EVSLKCLEAD
//
