ID H3CYF1_TETNG Unreviewed; 1816 AA.
AC H3CYF1;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 1.
DT 27-MAR-2024, entry version 72.
DE SubName: Full=Myosin VB {ECO:0000313|Ensembl:ENSTNIP00000013286.1};
OS Tetraodon nigroviridis (Spotted green pufferfish) (Chelonodon
OS nigroviridis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Tetraodon.
OX NCBI_TaxID=99883 {ECO:0000313|Ensembl:ENSTNIP00000013286.1, ECO:0000313|Proteomes:UP000007303};
RN [1] {ECO:0000313|Proteomes:UP000007303}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15496914; DOI=10.1038/nature03025;
RA Jaillon O., Aury J.-M., Brunet F., Petit J.-L., Stange-Thomann N.,
RA Mauceli E., Bouneau L., Fischer C., Ozouf-Costaz C., Bernot A., Nicaud S.,
RA Jaffe D., Fisher S., Lutfalla G., Dossat C., Segurens B., Dasilva C.,
RA Salanoubat M., Levy M., Boudet N., Castellano S., Anthouard V., Jubin C.,
RA Castelli V., Katinka M., Vacherie B., Biemont C., Skalli Z., Cattolico L.,
RA Poulain J., De Berardinis V., Cruaud C., Duprat S., Brottier P.,
RA Coutanceau J.-P., Gouzy J., Parra G., Lardier G., Chapple C.,
RA McKernan K.J., McEwan P., Bosak S., Kellis M., Volff J.-N., Guigo R.,
RA Zody M.C., Mesirov J., Lindblad-Toh K., Birren B., Nusbaum C., Kahn D.,
RA Robinson-Rechavi M., Laudet V., Schachter V., Quetier F., Saurin W.,
RA Scarpelli C., Wincker P., Lander E.S., Weissenbach J., Roest Crollius H.;
RT "Genome duplication in the teleost fish Tetraodon nigroviridis reveals the
RT early vertebrate proto-karyotype.";
RL Nature 431:946-957(2004).
RN [2] {ECO:0000313|Ensembl:ENSTNIP00000013286.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the TRAFAC class myosin-kinesin ATPase
CC superfamily. Myosin family. {ECO:0000256|ARBA:ARBA00008314,
CC ECO:0000256|PROSITE-ProRule:PRU00782}.
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DR Ensembl; ENSTNIT00000013478.1; ENSTNIP00000013286.1; ENSTNIG00000010379.1.
DR GeneTree; ENSGT00940000155402; -.
DR HOGENOM; CLU_000192_9_1_1; -.
DR Proteomes; UP000007303; Unassembled WGS sequence.
DR GO; GO:0016459; C:myosin complex; IEA:UniProtKB-KW.
DR GO; GO:0003779; F:actin binding; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003774; F:cytoskeletal motor activity; IEA:UniProtKB-UniRule.
DR GO; GO:0048731; P:system development; IEA:UniProt.
DR CDD; cd01380; MYSc_Myo5; 1.
DR Gene3D; 1.10.10.820; -; 1.
DR Gene3D; 1.20.5.190; -; 3.
DR Gene3D; 1.20.58.530; -; 1.
DR Gene3D; 3.30.70.1590; -; 1.
DR Gene3D; 3.40.850.10; Kinesin motor domain; 1.
DR Gene3D; 1.20.120.720; Myosin VI head, motor domain, U50 subdomain; 1.
DR InterPro; IPR002710; Dilute_dom.
DR InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR InterPro; IPR036961; Kinesin_motor_dom_sf.
DR InterPro; IPR001609; Myosin_head_motor_dom.
DR InterPro; IPR004009; Myosin_N.
DR InterPro; IPR036103; MYSc_Myo5.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR13140; MYOSIN; 1.
DR PANTHER; PTHR13140:SF289; UNCONVENTIONAL MYOSIN-XIX; 1.
DR Pfam; PF01843; DIL; 1.
DR Pfam; PF00612; IQ; 4.
DR Pfam; PF00063; Myosin_head; 1.
DR PRINTS; PR00193; MYOSINHEAVY.
DR SMART; SM01132; DIL; 1.
DR SMART; SM00015; IQ; 6.
DR SMART; SM00242; MYSc; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR PROSITE; PS51126; DILUTE; 1.
DR PROSITE; PS50096; IQ; 5.
DR PROSITE; PS51456; MYOSIN_MOTOR; 1.
DR PROSITE; PS51844; SH3_LIKE; 1.
PE 3: Inferred from homology;
KW Actin-binding {ECO:0000256|ARBA:ARBA00023203, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00782}; Coiled coil {ECO:0000256|SAM:Coils};
KW Motor protein {ECO:0000256|ARBA:ARBA00023175, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW Myosin {ECO:0000256|ARBA:ARBA00023123, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00782}; Reference proteome {ECO:0000313|Proteomes:UP000007303}.
FT DOMAIN 8..65
FT /note="Myosin N-terminal SH3-like"
FT /evidence="ECO:0000259|PROSITE:PS51844"
FT DOMAIN 69..756
FT /note="Myosin motor"
FT /evidence="ECO:0000259|PROSITE:PS51456"
FT DOMAIN 1491..1771
FT /note="Dilute"
FT /evidence="ECO:0000259|PROSITE:PS51126"
FT REGION 600..623
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 635..657
FT /note="Actin-binding"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00782"
FT REGION 1083..1117
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1163..1189
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 1193..1258
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1315..1404
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 1092..1117
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 163..170
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00782"
SQ SEQUENCE 1816 AA; 209456 MW; 3F584C91EE740BD1 CRC64;
LYSEELEEQF TRVWIPDPEE VWKAAEITRD YKEGETVLHL KLEDETPLEY AVGAKGKPLP
FLRNPDILVG ENDLTALSYL HEPAVLHNLR VRFLESNHIY TYCGIVLVAI NPYEQLQIYG
EEVITAYSGQ NMGDMDPHIF AVAEEAYKQM ARDERNQSII VSGESGAGKT VSAKYAMRFF
ATVGGSANDT NVEEKVLASS PIMEAIGNAK TTRNDNSSRF GKYIQIGFSR RYHIIGANMR
TYLLEKSRVV FQAEDERNYH IFYQLCASAS LPEFKDLALT SAEEFTYTSY GENIFIEGVN
DAEDFVKTRE GFVFFLGIKD STQNNVFKII ASILHLGNIE ICSERDEDSC HISRDDIHLK
HFCRLLGVEL QQMEHWLCHR KLVTSAETYV KNMTSKQANN ARAALAKHIY ARMFDWIVDH
INMALQTSSK QHSFIGVLDI YGFETFEVNS FEQFCINYAN EKLQQQFNSH VFKLEQEEYM
KEEIPWTMIE YYDNQPCIDL IEARLGVLDL LDEECKVPKG TDQNWAQKLY KQHSSSAHFQ
KPRMSNISFI IIHFADEVEY QCEGFLEKNR DRVYEEQINI LKASQFQLVA DLFHEKEDAG
PSKSARVNVR PAKSIPKASN KDHKKTVGHQ FRSSLHLLMD TLNATTPHYV RCIKPNDFKE
AFTFDSGRAV QQLRACGVLE TIRISAAGYP SRWTYSDFFN RYRVLMTKSD MMSTDKKLVC
KNLLKTLIKE PDMFQFGKTK IFFRAGQVAY LEKLRADKFR AACIKIQKTV RGWLQRVRYR
KIYRAAVTLQ RYGRGYLARR YAEYLRLSRA VVICQKQYRM VRERRAYLRV RQAVITIQAY
TRGMYTRRIY WVFLQHHRAM IIQKYVRGWL QRRKFNRARA AAITIQCAYR RTLAKRQLKQ
LKIEARSAEH LKKLNTGMEN KIVQMQRKMD EQSKDFKAQN EQLLLVNTTL GSEVNKLQKQ
LDQVRSKQDG EHLTSLQDEL EMLREQLQEA SADKKELEKE HSSEKMKLEK RVEELEKENA
LLKSEKEEMN QIILQQSLSS AGGGSIVSQS EASLQKELDQ ERQRYQNLVK EFSRLEQRYD
NLKEEFHPGH RRTTSNQSSI GSDSNYPSFS TSEVGDTEDA IQQVEEMGLE KAAMDISLFM
KLQKRVRELE QERRRLQASV EKMEEINRRK GSESRNTISE QESADQAYDS LKRQELETEN
KNLKNDLNEL RKTIADHASQ NNSSNELQDG YNLLLSQLKA ANEELDARKE EVLILKSQIV
STAQLLDKND NLPESNGVPE MTNGTEPMDK EEAVKAYNGL CESKKLLEAQ LQTQSKHHKD
ELEALHTQIE LLRDDIEKKQ EMLNYTASLS PEAKVEYSVQ QEITRLTNEN LDLKELVEKL
EKNEKKLKKQ LRIYMKKVQE LEASQAAAAQ NSRSKPELSR QVTVQRKEKD FEGMLEYSKE
EEAHLLKALI MDMRPSTVSA TVPCLPAYIL FMCIRHADYI NDDQKVESLL TSTINSVKKV
LKKNSDDFEM TSFWLANTSR LLHCLKQYSG DEAFMKQNTG KQNEHCLKNF DLTEYRQVLS
DLSIQIYQQL IKVAEGIIQP MIVSAMLESE SIPSLAGVKP MGYRNRSSSM DTDAGGPSSY
TLEALIRQLG QFLGIMQDHG MDPEIVGQVV RQLFHCINAV TLNNLLLRKD VCSWSNGMQL
RYNTTQMEEW LRANNLYSSN AAATLEPIIQ AAQLLQVKKK TIQDAEAICS LCSSLTTQQI
VKILNLYTPL NEFEERVTVS FIRNIQNGLQ ERNDPPQLLV DTKHVFPVLF PYTPSALSLE
TLHIPASLGL EFLVRV
//
