ID H3CZZ3_TETNG Unreviewed; 837 AA.
AC H3CZZ3;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 1.
DT 27-MAR-2024, entry version 54.
DE RecName: Full=Anoctamin {ECO:0000256|RuleBase:RU280814};
OS Tetraodon nigroviridis (Spotted green pufferfish) (Chelonodon
OS nigroviridis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Tetraodon.
OX NCBI_TaxID=99883 {ECO:0000313|Ensembl:ENSTNIP00000013829.1, ECO:0000313|Proteomes:UP000007303};
RN [1] {ECO:0000313|Proteomes:UP000007303}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15496914; DOI=10.1038/nature03025;
RA Jaillon O., Aury J.-M., Brunet F., Petit J.-L., Stange-Thomann N.,
RA Mauceli E., Bouneau L., Fischer C., Ozouf-Costaz C., Bernot A., Nicaud S.,
RA Jaffe D., Fisher S., Lutfalla G., Dossat C., Segurens B., Dasilva C.,
RA Salanoubat M., Levy M., Boudet N., Castellano S., Anthouard V., Jubin C.,
RA Castelli V., Katinka M., Vacherie B., Biemont C., Skalli Z., Cattolico L.,
RA Poulain J., De Berardinis V., Cruaud C., Duprat S., Brottier P.,
RA Coutanceau J.-P., Gouzy J., Parra G., Lardier G., Chapple C.,
RA McKernan K.J., McEwan P., Bosak S., Kellis M., Volff J.-N., Guigo R.,
RA Zody M.C., Mesirov J., Lindblad-Toh K., Birren B., Nusbaum C., Kahn D.,
RA Robinson-Rechavi M., Laudet V., Schachter V., Quetier F., Saurin W.,
RA Scarpelli C., Wincker P., Lander E.S., Weissenbach J., Roest Crollius H.;
RT "Genome duplication in the teleost fish Tetraodon nigroviridis reveals the
RT early vertebrate proto-karyotype.";
RL Nature 431:946-957(2004).
RN [2] {ECO:0000313|Ensembl:ENSTNIP00000013829.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU280814}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141,
CC ECO:0000256|RuleBase:RU280814}.
CC -!- SIMILARITY: Belongs to the anoctamin family.
CC {ECO:0000256|ARBA:ARBA00009671, ECO:0000256|RuleBase:RU280814}.
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DR AlphaFoldDB; H3CZZ3; -.
DR STRING; 99883.ENSTNIP00000013829; -.
DR Ensembl; ENSTNIT00000014024.1; ENSTNIP00000013829.1; ENSTNIG00000010899.1.
DR GeneTree; ENSGT00940000164482; -.
DR HOGENOM; CLU_006685_0_1_1; -.
DR InParanoid; H3CZZ3; -.
DR OMA; KWMHRTQ; -.
DR TreeFam; TF314265; -.
DR Proteomes; UP000007303; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR InterPro; IPR032394; Anoct_dimer.
DR InterPro; IPR007632; Anoctamin.
DR InterPro; IPR049452; Anoctamin_TM.
DR PANTHER; PTHR12308; ANOCTAMIN; 1.
DR PANTHER; PTHR12308:SF15; ANOCTAMIN; 1.
DR Pfam; PF16178; Anoct_dimer; 1.
DR Pfam; PF04547; Anoctamin; 1.
PE 3: Inferred from homology;
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU280814};
KW Reference proteome {ECO:0000313|Proteomes:UP000007303};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU280814};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU280814}.
FT TRANSMEM 266..292
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU280814"
FT TRANSMEM 346..364
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU280814"
FT TRANSMEM 426..453
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU280814"
FT TRANSMEM 465..488
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU280814"
FT TRANSMEM 509..531
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU280814"
FT TRANSMEM 632..654
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU280814"
FT TRANSMEM 682..706
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU280814"
FT TRANSMEM 758..781
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU280814"
FT DOMAIN 50..255
FT /note="Anoctamin dimerisation"
FT /evidence="ECO:0000259|Pfam:PF16178"
FT DOMAIN 258..802
FT /note="Anoctamin transmembrane"
FT /evidence="ECO:0000259|Pfam:PF04547"
SQ SEQUENCE 837 AA; 97532 MW; D785250746DB94E3 CRC64;
MLRKGSEKKD REVLLDLDHE GSMNSYGSLQ NGSSSTPKSV SACFNHSRYF VLVWETSSQG
TRPEQEGTSD IKLEQWRERF LRNLRAAGLL MEKVLPSRVA SRIRRDSNVH LKSPLQAQPY
LDFNSSARWL RHLCIPNIML QQVPNRPLDY YTCAFRKSKM ENFLGSHDQE NFFTNTQRHR
VAYEILTRTS YGKRRRAQVG VDRLLNEGVF TTTFPLHEGS FRLPQCEIHP EELNRRQILY
QYWARWRNWH KYQPLDHIRE YFGEKIAFYF AWLGFYTTWL LPAALVGTLV FLSGLMSMST
NTTAKEVCNS GGNYLMCPLC DTCNAWNIST TCTMAKLGYL FDHPGTVFFS IFMSFWSVSF
LEYWKRKMVT LAHHWDCMEF HEEEERPRPE FAAMATTMEP NPVTGVKEPY FPEKTRMSRM
LTGSMVIVMM LCVVMIFLVT VVMCRGILTV VMFHTRSHIL QTEAVTIANI LSSIVNLCLI
LLMGRIYTAL AEQLTKWEMH RTQTQYENAF IFKVFIFQFV NFYSSPFYVA FFKGRFVGYP
NNYGRLFGMR NEDCGPGGCL IELAQQLFII MVGKQFINNV QEFVIPKVKA WLQKRTLSKV
LGVKEALQIQ RWEEDYQLVK CEGLFEEYLE MVLQFGFITI FVAAFPLAPL FALLNNWVEI
RLDAHKFVCE YQRPVAERAQ NIGVWLNILE ILSHMSVTAN AFVLAFTSEF LPRLLYQYKF
DNDLHGYVNF TLAYAPANYT DYPQCRYALS HEWSSFTLVY WDLLVFSHFG YYYCHVVFFV
LRAIDWIIPD IPESLEVKMK RERYLAKQAL AENHEVLFQG VPSATPGTSS PEVSIPN
//
