ID H3D2R5_TETNG Unreviewed; 786 AA.
AC H3D2R5;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 1.
DT 27-MAR-2024, entry version 72.
DE RecName: Full=Pleckstrin and Sec7 domain containing a {ECO:0008006|Google:ProtNLM};
OS Tetraodon nigroviridis (Spotted green pufferfish) (Chelonodon
OS nigroviridis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Tetraodon.
OX NCBI_TaxID=99883 {ECO:0000313|Ensembl:ENSTNIP00000014803.1, ECO:0000313|Proteomes:UP000007303};
RN [1] {ECO:0000313|Proteomes:UP000007303}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15496914; DOI=10.1038/nature03025;
RA Jaillon O., Aury J.-M., Brunet F., Petit J.-L., Stange-Thomann N.,
RA Mauceli E., Bouneau L., Fischer C., Ozouf-Costaz C., Bernot A., Nicaud S.,
RA Jaffe D., Fisher S., Lutfalla G., Dossat C., Segurens B., Dasilva C.,
RA Salanoubat M., Levy M., Boudet N., Castellano S., Anthouard V., Jubin C.,
RA Castelli V., Katinka M., Vacherie B., Biemont C., Skalli Z., Cattolico L.,
RA Poulain J., De Berardinis V., Cruaud C., Duprat S., Brottier P.,
RA Coutanceau J.-P., Gouzy J., Parra G., Lardier G., Chapple C.,
RA McKernan K.J., McEwan P., Bosak S., Kellis M., Volff J.-N., Guigo R.,
RA Zody M.C., Mesirov J., Lindblad-Toh K., Birren B., Nusbaum C., Kahn D.,
RA Robinson-Rechavi M., Laudet V., Schachter V., Quetier F., Saurin W.,
RA Scarpelli C., Wincker P., Lander E.S., Weissenbach J., Roest Crollius H.;
RT "Genome duplication in the teleost fish Tetraodon nigroviridis reveals the
RT early vertebrate proto-karyotype.";
RL Nature 431:946-957(2004).
RN [2] {ECO:0000313|Ensembl:ENSTNIP00000014803.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell projection, ruffle membrane
CC {ECO:0000256|ARBA:ARBA00004632}.
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DR AlphaFoldDB; H3D2R5; -.
DR STRING; 99883.ENSTNIP00000014803; -.
DR Ensembl; ENSTNIT00000015004.1; ENSTNIP00000014803.1; ENSTNIG00000011848.1.
DR GeneTree; ENSGT00940000156591; -.
DR HOGENOM; CLU_011021_4_0_1; -.
DR InParanoid; H3D2R5; -.
DR OMA; AKWEFFF; -.
DR TreeFam; TF319755; -.
DR Proteomes; UP000007303; Unassembled WGS sequence.
DR GO; GO:0032587; C:ruffle membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR GO; GO:0005543; F:phospholipid binding; IEA:InterPro.
DR GO; GO:0032012; P:regulation of ARF protein signal transduction; IEA:InterPro.
DR CDD; cd13295; PH_EFA6; 1.
DR CDD; cd00171; Sec7; 1.
DR Gene3D; 1.10.1000.11; Arf Nucleotide-binding Site Opener,domain 2; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR041681; PH_9.
DR InterPro; IPR001605; PH_dom-spectrin-type.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR023394; Sec7_C_sf.
DR InterPro; IPR000904; Sec7_dom.
DR InterPro; IPR035999; Sec7_dom_sf.
DR PANTHER; PTHR10663; GUANYL-NUCLEOTIDE EXCHANGE FACTOR; 1.
DR PANTHER; PTHR10663:SF334; PH AND SEC7 DOMAIN-CONTAINING PROTEIN 1; 1.
DR Pfam; PF15410; PH_9; 1.
DR Pfam; PF01369; Sec7; 1.
DR PRINTS; PR00683; SPECTRINPH.
DR SMART; SM00233; PH; 1.
DR SMART; SM00222; Sec7; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF48425; Sec7 domain; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS50190; SEC7; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000007303}.
FT DOMAIN 277..467
FT /note="SEC7"
FT /evidence="ECO:0000259|PROSITE:PS50190"
FT DOMAIN 518..631
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT REGION 82..105
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 232..289
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 491..512
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 744..786
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 83..101
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 232..256
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 491..505
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 786 AA; 87085 MW; B0DF93227E77F109 CRC64;
SLHCQRIARA KWEFLFGTPA EDAACRGEKV TPPPAVVGTS PKTGIIRRTL KYSETDLDAV
PLRCYRETDI DEVLLAEQED ADSAFGSNRS VQGTSGTGSS PLGGLAYGAA EVAEGGDNRK
QQYAAEEEPE LFGHLKKRAT ETFFDNHHPA LKSPLLVSGP RCGAEDTFSC HFENIMESHR
AKGTSYNSLD SEELLTSSTQ TVLTFDLPTL TPTIHAPLSF APLAHDERPS LSDSVFTVTG
DSDATRAPSS ERLSSGSDEA PPRGRDRRSG LLTVPKGSTR EKARLASDPE VDQDLIDRLG
LSSSDTLTNG SRHTDVAAAK RLAKRLFNLD GFRKSDVARH LSKNNDFSCM VAEEYLAFFD
FTGHSLDQAL RTFLRQFALM GETQERERVL SHFSKRYLCC NPRAMPSEDA VHTLTCALML
LNTDLHGQNV GKRMSCAQFI GNLEGLNDGQ DFSKDLLKAL YNSIKSQKLQ WTLDEEELRK
SFSELGDSLC DSNASRSTKQ VGSSEKPLPV GSEPSGMLLY KNGFLVRKVH ADSDGKRTPR
GKRGWKTFYA ILKGLILYLQ KGEYRPDKQL SDEDLKNAVS IHHSLAMKAS DYSKRPNVFY
LRTADWRVYL FQAPNAEQMQ SWITRINTVA AMFSAPPFPA AIGSQKKFSR PLLPGTMSKL
AEEEQVRSHE ARFKSLSTEL AELRSYPPDR KLKGRELEEY RHRDEYLEFE KTRYGTYVML
LRAKIQSGAE DLAAFESHLL EENGLQRSHS SPTLADSSQV SQASSTLDGG NSSRASGGSG
SKLRQE
//